283 related articles for article (PubMed ID: 21594775)
1. High-throughput screening of libraries of compounds to identify CFTR modulators.
Pedemonte N; Zegarra-Moran O; Galietta LJ
Methods Mol Biol; 2011; 741():13-21. PubMed ID: 21594775
[TBL] [Abstract][Full Text] [Related]
2. A Homogeneous Cell-Based Halide-Sensitive Yellow Fluorescence Protein Assay to Identify Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Ion Channel.
Smith E; Giuliano KA; Shumate J; Baillargeon P; McEwan B; Cullen MD; Miller JP; Drew L; Scampavia L; Spicer TP
Assay Drug Dev Technol; 2017 Dec; 15(8):395-406. PubMed ID: 29172645
[TBL] [Abstract][Full Text] [Related]
3. Identification of natural coumarin compounds that rescue defective DeltaF508-CFTR chloride channel gating.
Xu LN; Na WL; Liu X; Hou SG; Lin S; Yang H; Ma TH
Clin Exp Pharmacol Physiol; 2008 Aug; 35(8):878-83. PubMed ID: 18430055
[TBL] [Abstract][Full Text] [Related]
4. Improved fluorescence assays to measure the defects associated with F508del-CFTR allow identification of new active compounds.
Langron E; Simone MI; Delalande CM; Reymond JL; Selwood DL; Vergani P
Br J Pharmacol; 2017 Apr; 174(7):525-539. PubMed ID: 28094839
[TBL] [Abstract][Full Text] [Related]
5. Optimization of a Yellow fluorescent protein-based iodide influx high-throughput screening assay for cystic fibrosis transmembrane conductance regulator (CFTR) modulators.
Sui J; Cotard S; Andersen J; Zhu P; Staunton J; Lee M; Lin S
Assay Drug Dev Technol; 2010 Dec; 8(6):656-68. PubMed ID: 21050066
[TBL] [Abstract][Full Text] [Related]
6. Repairing mutated proteins--development of small molecules targeting defects in the cystic fibrosis transmembrane conductance regulator.
Merk D; Schubert-Zsilavecz M
Expert Opin Drug Discov; 2013 Jun; 8(6):691-708. PubMed ID: 23574506
[TBL] [Abstract][Full Text] [Related]
7. CFTR chloride channel drug discovery--inhibitors as antidiarrheals and activators for therapy of cystic fibrosis.
Verkman AS; Lukacs GL; Galietta LJ
Curr Pharm Des; 2006; 12(18):2235-47. PubMed ID: 16787252
[TBL] [Abstract][Full Text] [Related]
8. Identification of Compounds That Promote Readthrough of Premature Termination Codons in the CFTR.
Smith E; Dukovski D; Shumate J; Scampavia L; Miller JP; Spicer TP
SLAS Discov; 2021 Feb; 26(2):205-215. PubMed ID: 33016182
[TBL] [Abstract][Full Text] [Related]
9. Simple image-based no-wash method for quantitative detection of surface expressed CFTR.
Larsen MB; Hu J; Frizzell RA; Watkins SC
Methods; 2016 Mar; 96():40-45. PubMed ID: 26361332
[TBL] [Abstract][Full Text] [Related]
10. Alpha-aminoazaheterocyclic-methylglyoxal adducts do not inhibit cystic fibrosis transmembrane conductance regulator chloride channel activity.
Sonawane ND; Zegarra-Moran O; Namkung W; Galietta LJ; Verkman AS
J Pharmacol Exp Ther; 2008 May; 325(2):529-35. PubMed ID: 18272811
[TBL] [Abstract][Full Text] [Related]
11. Use of a High-Throughput Phenotypic Screening Strategy to Identify Amplifiers, a Novel Pharmacological Class of Small Molecules That Exhibit Functional Synergy with Potentiators and Correctors.
Giuliano KA; Wachi S; Drew L; Dukovski D; Green O; Bastos C; Cullen MD; Hauck S; Tait BD; Munoz B; Lee PS; Miller JP
SLAS Discov; 2018 Feb; 23(2):111-121. PubMed ID: 28898585
[TBL] [Abstract][Full Text] [Related]
12. Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease.
Pasyk S; Li C; Ramjeesingh M; Bear CE
Biochem J; 2009 Feb; 418(1):185-90. PubMed ID: 18945216
[TBL] [Abstract][Full Text] [Related]
13. Repair of CFTR folding defects with correctors that function as pharmacological chaperones.
Loo TW; Clarke DM
Methods Mol Biol; 2011; 741():23-37. PubMed ID: 21594776
[TBL] [Abstract][Full Text] [Related]
14. Synthesis of 4-thiophen-2'-yl-1,4-dihydropyridines as potentiators of the CFTR chloride channel.
Cateni F; Zacchigna M; Pedemonte N; Galietta LJ; Mazzei MT; Fossa P; Giampieri M; Mazzei M
Bioorg Med Chem; 2009 Dec; 17(23):7894-903. PubMed ID: 19880323
[TBL] [Abstract][Full Text] [Related]
15. Microfluidics platform for single-shot dose-response analysis of chloride channel-modulating compounds.
Jin BJ; Ko EA; Namkung W; Verkman AS
Lab Chip; 2013 Oct; 13(19):3862-7. PubMed ID: 23907501
[TBL] [Abstract][Full Text] [Related]
16. A rapid membrane potential assay to monitor CFTR function and inhibition.
Maitra R; Sivashanmugam P; Warner K
J Biomol Screen; 2013 Oct; 18(9):1132-7. PubMed ID: 23653393
[TBL] [Abstract][Full Text] [Related]
17. A novel fluorescent sensor for measurement of CFTR function by flow cytometry.
Vijftigschild LA; van der Ent CK; Beekman JM
Cytometry A; 2013 Jun; 83(6):576-84. PubMed ID: 23463616
[TBL] [Abstract][Full Text] [Related]
18. Discovery of alpha-aminoazaheterocycle-methylglyoxal adducts as a new class of high-affinity inhibitors of cystic fibrosis transmembrane conductance regulator chloride channels.
Routaboul C; Norez C; Melin P; Molina MC; Boucherle B; Bossard F; Noel S; Robert R; Gauthier C; Becq F; Décout JL
J Pharmacol Exp Ther; 2007 Sep; 322(3):1023-35. PubMed ID: 17578899
[TBL] [Abstract][Full Text] [Related]
19. Structural analog of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect.
Robert R; Carlile GW; Pavel C; Liu N; Anjos SM; Liao J; Luo Y; Zhang D; Thomas DY; Hanrahan JW
Mol Pharmacol; 2008 Feb; 73(2):478-89. PubMed ID: 17975008
[TBL] [Abstract][Full Text] [Related]
20. Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonists.
Galietta LV; Jayaraman S; Verkman AS
Am J Physiol Cell Physiol; 2001 Nov; 281(5):C1734-42. PubMed ID: 11600438
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]