BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

221 related articles for article (PubMed ID: 21613414)

  • 1. GLUT1 enhances mTOR activity independently of TSC2 and AMPK.
    Buller CL; Heilig CW; Brosius FC
    Am J Physiol Renal Physiol; 2011 Sep; 301(3):F588-96. PubMed ID: 21613414
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Enhanced expression of glucose transporter-1 in vascular smooth muscle cells via the Akt/tuberous sclerosis complex subunit 2 (TSC2)/mammalian target of rapamycin (mTOR)/ribosomal S6 protein kinase (S6K) pathway in experimental renal failure.
    Lin CY; Hsu SC; Lee HS; Lin SH; Tsai CS; Huang SM; Shih CC; Hsu YJ
    J Vasc Surg; 2013 Feb; 57(2):475-85. PubMed ID: 23265586
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.
    Tee AR; Manning BD; Roux PP; Cantley LC; Blenis J
    Curr Biol; 2003 Aug; 13(15):1259-68. PubMed ID: 12906785
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression.
    Buller CL; Loberg RD; Fan MH; Zhu Q; Park JL; Vesely E; Inoki K; Guan KL; Brosius FC
    Am J Physiol Cell Physiol; 2008 Sep; 295(3):C836-43. PubMed ID: 18650261
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses.
    Smith EM; Finn SG; Tee AR; Browne GJ; Proud CG
    J Biol Chem; 2005 May; 280(19):18717-27. PubMed ID: 15772076
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.
    Karbowniczek M; Cash T; Cheung M; Robertson GP; Astrinidis A; Henske EP
    J Biol Chem; 2004 Jul; 279(29):29930-7. PubMed ID: 15150271
    [TBL] [Abstract][Full Text] [Related]  

  • 7. PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade.
    Liu Z; Chen X; Wang Y; Peng H; Wang Y; Jing Y; Zhang H
    J Biol Chem; 2014 Oct; 289(43):29739-49. PubMed ID: 25164809
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways.
    Gau CL; Kato-Stankiewicz J; Jiang C; Miyamoto S; Guo L; Tamanoi F
    Mol Cancer Ther; 2005 Jun; 4(6):918-26. PubMed ID: 15956249
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.
    Garami A; Zwartkruis FJ; Nobukuni T; Joaquin M; Roccio M; Stocker H; Kozma SC; Hafen E; Bos JL; Thomas G
    Mol Cell; 2003 Jun; 11(6):1457-66. PubMed ID: 12820960
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.
    Li Y; Inoki K; Guan KL
    Mol Cell Biol; 2004 Sep; 24(18):7965-75. PubMed ID: 15340059
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner.
    Castro AF; Rebhun JF; Clark GJ; Quilliam LA
    J Biol Chem; 2003 Aug; 278(35):32493-6. PubMed ID: 12842888
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
    Inoki K; Li Y; Xu T; Guan KL
    Genes Dev; 2003 Aug; 17(15):1829-34. PubMed ID: 12869586
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydrogenase-mediated regulation of Rheb.
    Lee MN; Ha SH; Kim J; Koh A; Lee CS; Kim JH; Jeon H; Kim DH; Suh PG; Ryu SH
    Mol Cell Biol; 2009 Jul; 29(14):3991-4001. PubMed ID: 19451232
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Deacetylation of S6 kinase promotes high glucose-induced glomerular mesangial cell hypertrophy and matrix protein accumulation.
    Das F; Maity S; Ghosh-Choudhury N; Kasinath BS; Ghosh Choudhury G
    J Biol Chem; 2019 Jun; 294(24):9440-9460. PubMed ID: 31028173
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Rhebbing up mTOR: new insights on TSC1 and TSC2, and the pathogenesis of tuberous sclerosis.
    Kwiatkowski DJ
    Cancer Biol Ther; 2003; 2(5):471-6. PubMed ID: 14614311
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Phospholipase D1 is an effector of Rheb in the mTOR pathway.
    Sun Y; Fang Y; Yoon MS; Zhang C; Roccio M; Zwartkruis FJ; Armstrong M; Brown HA; Chen J
    Proc Natl Acad Sci U S A; 2008 Jun; 105(24):8286-91. PubMed ID: 18550814
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity.
    Finlay GA; Malhowski AJ; Liu Y; Fanburg BL; Kwiatkowski DJ; Toksoz D
    Cancer Res; 2007 Oct; 67(20):9878-86. PubMed ID: 17942919
    [TBL] [Abstract][Full Text] [Related]  

  • 18. cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity.
    Xie J; Ponuwei GA; Moore CE; Willars GB; Tee AR; Herbert TP
    Cell Signal; 2011 Dec; 23(12):1927-35. PubMed ID: 21763421
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Frequent [corrected] hyperphosphorylation of ribosomal protein S6 [corrected] in lymphangioleiomyomatosis-associated angiomyolipomas.
    Robb VA; Astrinidis A; Henske EP
    Mod Pathol; 2006 Jun; 19(6):839-46. PubMed ID: 16575396
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of follicular differentiation.
    Alam H; Maizels ET; Park Y; Ghaey S; Feiger ZJ; Chandel NS; Hunzicker-Dunn M
    J Biol Chem; 2004 May; 279(19):19431-40. PubMed ID: 14982927
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.