148 related articles for article (PubMed ID: 21628455)
1. Increasing hydrophobicity or disulfide bridging at the factor VIII A1 and C2 domain interface enhances procofactor stability.
Wakabayashi H; Griffiths AE; Fay PJ
J Biol Chem; 2011 Jul; 286(29):25748-55. PubMed ID: 21628455
[TBL] [Abstract][Full Text] [Related]
2. Modification of interdomain interfaces within the A3C1C2 subunit of factor VIII affects its stability and activity.
Wakabayashi H; Fay PJ
Biochemistry; 2013 Jun; 52(22):3921-9. PubMed ID: 23659383
[TBL] [Abstract][Full Text] [Related]
3. Cofactor activity in factor VIIIa of the blood clotting pathway is stabilized by an interdomain bond between His281 and Ser524 formed in factor VIII.
Wakabayashi H; Monaghan M; Fay PJ
J Biol Chem; 2014 May; 289(20):14020-9. PubMed ID: 24692542
[TBL] [Abstract][Full Text] [Related]
4. Combining mutations that modulate inter-subunit interactions and proteolytic inactivation enhance the stability of factor VIIIa.
Wakabayashi H; Wintermute JM; Fay PJ
Thromb Haemost; 2014 Jul; 112(1):43-52. PubMed ID: 24599523
[TBL] [Abstract][Full Text] [Related]
5. Identification of residues contributing to A2 domain-dependent structural stability in factor VIII and factor VIIIa.
Wakabayashi H; Fay PJ
J Biol Chem; 2008 Apr; 283(17):11645-51. PubMed ID: 18299331
[TBL] [Abstract][Full Text] [Related]
6. Combining mutations of charged residues at the A2 domain interface enhances factor VIII stability over single point mutations.
Wakabayashi H; Griffiths AE; Fay PJ
J Thromb Haemost; 2009 Mar; 7(3):438-44. PubMed ID: 19067791
[TBL] [Abstract][Full Text] [Related]
7. Variable contributions of basic residues forming an APC exosite in the binding and inactivation of factor VIIIa.
Takeyama M; Wintermute JM; Manithody C; Rezaie AR; Fay PJ
Biochemistry; 2013 Apr; 52(13):2228-35. PubMed ID: 23480827
[TBL] [Abstract][Full Text] [Related]
8. Replacing the factor VIII C1 domain with a second C2 domain reduces factor VIII stability and affinity for factor IXa.
Wakabayashi H; Fay PJ
J Biol Chem; 2013 Oct; 288(43):31289-97. PubMed ID: 24030831
[TBL] [Abstract][Full Text] [Related]
9. Stabilizing interactions between D666-S1787 and T657-Y1792 at the A2-A3 interface support factor VIIIa stability in the blood clotting pathway.
Monaghan M; Wakabayashi H; Griffiths AE; Fay PJ
J Thromb Haemost; 2016 May; 14(5):1021-30. PubMed ID: 26878264
[TBL] [Abstract][Full Text] [Related]
10. Generation of enhanced stability factor VIII variants by replacement of charged residues at the A2 domain interface.
Wakabayashi H; Varfaj F; Deangelis J; Fay PJ
Blood; 2008 Oct; 112(7):2761-9. PubMed ID: 18650448
[TBL] [Abstract][Full Text] [Related]
11. Contribution of A1 subunit residue Q316 in thrombin-activated factor VIII to A2 subunit dissociation.
Parker ET; Lollar P
Biochemistry; 2007 Aug; 46(34):9737-42. PubMed ID: 17676877
[TBL] [Abstract][Full Text] [Related]
12. Enhanced factor VIIIa stability of A2 domain interface variants results from an increased apparent affinity for the A2 subunit. Results from an increased apparent affinity for the A2 subunit.
Monaghan M; Wakabayashi H; Griffiths A; Wintermute J; Fay PJ
Thromb Haemost; 2014 Sep; 112(3):495-502. PubMed ID: 24899227
[TBL] [Abstract][Full Text] [Related]
13. Intrinsic stability and functional properties of disulfide bond-stabilized coagulation factor VIIIa variants.
Gale AJ; Radtke KP; Cunningham MA; Chamberlain D; Pellequer JL; Griffin JH
J Thromb Haemost; 2006 Jun; 4(6):1315-22. PubMed ID: 16706977
[TBL] [Abstract][Full Text] [Related]
14. An engineered interdomain disulfide bond stabilizes human blood coagulation factor VIIIa.
Gale AJ; Pellequer JL
J Thromb Haemost; 2003 Sep; 1(9):1966-71. PubMed ID: 12941038
[TBL] [Abstract][Full Text] [Related]
15. Molecular orientation of factor VIIIa on the phospholipid membrane surface determined by fluorescence resonance energy transfer.
Wakabayashi H; Fay PJ
Biochem J; 2013 Jun; 452(2):293-301. PubMed ID: 23521092
[TBL] [Abstract][Full Text] [Related]
16. A3 domain residue Glu1829 contributes to A2 subunit retention in factor VIIIa.
Wakabayashi H; Zhou Q; Varfaj F; Fay PJ
J Thromb Haemost; 2007 May; 5(5):996-1001. PubMed ID: 17371488
[TBL] [Abstract][Full Text] [Related]
17. Hemophilia A mutations associated with 1-stage/2-stage activity discrepancy disrupt protein-protein interactions within the triplicated A domains of thrombin-activated factor VIIIa.
Pipe SW; Saenko EL; Eickhorst AN; Kemball-Cook G; Kaufman RJ
Blood; 2001 Feb; 97(3):685-91. PubMed ID: 11157485
[TBL] [Abstract][Full Text] [Related]
18. Disulfide bond-stabilized factor VIII has prolonged factor VIIIa activity and improved potency in whole blood clotting assays.
Radtke KP; Griffin JH; Riceberg J; Gale AJ
J Thromb Haemost; 2007 Jan; 5(1):102-8. PubMed ID: 17059431
[TBL] [Abstract][Full Text] [Related]
19. A1 subunit-mediated regulation of thrombin-activated factor VIII A2 subunit dissociation.
Parker ET; Doering CB; Lollar P
J Biol Chem; 2006 May; 281(20):13922-30. PubMed ID: 16513639
[TBL] [Abstract][Full Text] [Related]
20. Contribution of factor VIIIa A2 and A3-C1-C2 subunits to the affinity for factor IXa in factor Xase.
Jenkins PV; Dill JL; Zhou Q; Fay PJ
Biochemistry; 2004 May; 43(17):5094-101. PubMed ID: 15109268
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]