BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

97 related articles for article (PubMed ID: 21641796)

  • 1. Design, synthesis and biological activity of novel peptidyl benzyl ketone FVIIa inhibitors.
    Storgaard M; Henriksen ST; Zaragoza F; Peschke B; Tanner D
    Bioorg Med Chem Lett; 2011 Jul; 21(13):3918-22. PubMed ID: 21641796
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-based design of P3 moieties in the peptide mimetic factor VIIa inhibitor.
    Kadono S; Sakamoto A; Kikuchi Y; Oh-eda M; Yabuta N; Yoshihashi K; Kitazawa T; Suzuki T; Koga T; Hattori K; Shiraishi T; Haramura M; Kodama H; Ono Y; Esaki T; Sato H; Watanabe Y; Itoh S; Ohta M; Kozono T
    Biochem Biophys Res Commun; 2005 Feb; 327(2):589-96. PubMed ID: 15629154
    [TBL] [Abstract][Full Text] [Related]  

  • 3. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
    Costanzo MJ; Almond HR; Hecker LR; Schott MR; Yabut SC; Zhang HC; Andrade-Gordon P; Corcoran TW; Giardino EC; Kauffman JA; Lewis JM; de Garavilla L; Haertlein BJ; Maryanoff BE
    J Med Chem; 2005 Mar; 48(6):1984-2008. PubMed ID: 15771442
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Polymer-assisted solution-phase library synthesis and crystal structure of alpha-ketothiazoles as tissue factor VIIa inhibitors.
    Parlow JJ; Dice TA; Lachance RM; Girard TJ; Stevens AM; Stegeman RA; Stallings WC; Kurumbail RG; South MS
    J Med Chem; 2003 Sep; 46(19):4043-9. PubMed ID: 12954057
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex.
    Parlow JJ; Case BL; Dice TA; Fenton RL; Hayes MJ; Jones DE; Neumann WL; Wood RS; Lachance RM; Girard TJ; Nicholson NS; Clare M; Stegeman RA; Stevens AM; Stallings WC; Kurumbail RG; South MS
    J Med Chem; 2003 Sep; 46(19):4050-62. PubMed ID: 12954058
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Sugar amino acid based peptide epoxyketones as potential proteasome inhibitors.
    Risseeuw MD; Florea BI; van der Marel GA; Overkleeft HS; Overhand M
    Bioorg Chem; 2010 Oct; 38(5):202-9. PubMed ID: 20493511
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores.
    Kotian PL; Krishnan R; Rowland S; El-Kattan Y; Saini SK; Upshaw R; Bantia S; Arnold S; Babu YS; Chand P
    Bioorg Med Chem; 2009 Jun; 17(11):3934-58. PubMed ID: 19409795
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The effect of active site-inhibited factor VIIa on tissue factor-initiated coagulation using platelets before and after aspirin administration.
    Kjalke M; Oliver JA; Monroe DM; Hoffman M; Ezban M; Hedner U; Roberts HR
    Thromb Haemost; 1997 Oct; 78(4):1202-8. PubMed ID: 9364985
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Novel interactions of large P3 moiety and small P4 moiety in the binding of the peptide mimetic factor VIIa inhibitor.
    Kadono S; Sakamoto A; Kikuchi Y; Oh-Eda M; Yabuta N; Yoshihashi K; Kitazawa T; Suzuki T; Koga T; Hattori K; Shiraishi T; Haramura M; Kodama H; Ono Y; Esaki T; Sato H; Watanabe Y; Itoh S; Ohta M; Kozono T
    Biochem Biophys Res Commun; 2005 Jan; 326(4):859-65. PubMed ID: 15607748
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa.
    Persson E; Olsen OH
    FEBS J; 2009 Jun; 276(11):3099-109. PubMed ID: 19490111
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Peptides and pseudopeptides incorporating D-Phe-Pro-Arg and Arg-Gly-Asp lead sequences as potential antithrombotic agents.
    Ilas J; Hudecz F; Süli-Vargha H; Kikelj D
    J Pept Sci; 2008 Aug; 14(8):946-53. PubMed ID: 18383437
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure-activity study of tripeptide thrombin inhibitors using alpha-alkyl amino acids and other conformationally constrained amino acid substitutions.
    Shuman RT; Rothenberger RB; Campbell CS; Smith GF; Gifford-Moore DS; Paschal JW; Gesellchen PD
    J Med Chem; 1995 Oct; 38(22):4446-53. PubMed ID: 7473571
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Potent peptide alpha-ketohydroxamate inhibitors of recombinant human calpain I.
    Josef KA; Kauer FW; Bihovsky R
    Bioorg Med Chem Lett; 2001 Oct; 11(19):2615-7. PubMed ID: 11551762
    [TBL] [Abstract][Full Text] [Related]  

  • 14. New substrate analogue furin inhibitors derived from 4-amidinobenzylamide.
    Becker GL; Hardes K; Steinmetzer T
    Bioorg Med Chem Lett; 2011 Aug; 21(16):4695-7. PubMed ID: 21757345
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Novel morpholinone-based D-Phe-Pro-Arg mimics as potential thrombin inhibitors: design, synthesis, and X-ray crystal structure of an enzyme inhibitor complex.
    Dahlgren A; Johansson PO; Kvarnström I; Musil D; Nilsson I; Samuelsson B
    Bioorg Med Chem; 2002 Jun; 10(6):1829-39. PubMed ID: 11937341
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design of novel and potent cPLA2α inhibitors containing an α-methyl-2-ketothiazole as a metabolically stable serine trap.
    Mete A; Andrews G; Bernstein M; Connolly S; Hartopp P; Jackson CG; Lewis R; Martin I; Murray D; Riley R; Robinson DH; Smith GM; Wells E; Withnall WJ
    Bioorg Med Chem Lett; 2011 May; 21(10):3128-33. PubMed ID: 21450464
    [TBL] [Abstract][Full Text] [Related]  

  • 17. BMS-593214, an active site-directed factor VIIa inhibitor: enzyme kinetics, antithrombotic and antihaemostatic studies.
    Wong PC; Luettgen JM; Rendina AR; Kettner CA; Xin B; Knabb RM; Wexler R; Priestley ES
    Thromb Haemost; 2010 Aug; 104(2):261-9. PubMed ID: 20589312
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Peptidyl human heart chymase inhibitors. 2. Discovery of highly selective difluoromethylene ketone derivatives with Glu at P3 site.
    Eda M; Ashimori A; Akahoshi F; Yoshimura T; Inoue Y; Fukaya C; Nakajima M; Fukuyama H; Imada T; Takai S; Shiota N; Miyazaki M; Nakamura N
    Bioorg Med Chem Lett; 1998 Apr; 8(8):919-24. PubMed ID: 9871512
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones.
    Cregge RJ; Durham SL; Farr RA; Gallion SL; Hare CM; Hoffman RV; Janusz MJ; Kim HO; Koehl JR; Mehdi S; Metz WA; Peet NP; Pelton JT; Schreuder HA; Sunder S; Tardif C
    J Med Chem; 1998 Jul; 41(14):2461-80. PubMed ID: 9651152
    [TBL] [Abstract][Full Text] [Related]  

  • 20. CoMFA investigations on two series of artificial peptide inhibitors of the serine protease thermitase. Synthesis of an inhibitor of predicted greater potency.
    Brandt W; Lehmann T; Willkomm C; Fittkau S; Barth A
    Int J Pept Protein Res; 1995 Jul; 46(1):73-8. PubMed ID: 7558600
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.