These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

227 related articles for article (PubMed ID: 21666715)

  • 1. Gamma-secretase inhibitors target tumor-initiating cells in a mouse model of ERBB2 breast cancer.
    Kondratyev M; Kreso A; Hallett RM; Girgis-Gabardo A; Barcelon ME; Ilieva D; Ware C; Majumder PK; Hassell JA
    Oncogene; 2012 Jan; 31(1):93-103. PubMed ID: 21666715
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model.
    Efferson CL; Winkelmann CT; Ware C; Sullivan T; Giampaoli S; Tammam J; Patel S; Mesiti G; Reilly JF; Gibson RE; Buser C; Yeatman T; Coppola D; Winter C; Clark EA; Draetta GF; Strack PR; Majumder PK
    Cancer Res; 2010 Mar; 70(6):2476-84. PubMed ID: 20197467
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers.
    Konishi J; Kawaguchi KS; Vo H; Haruki N; Gonzalez A; Carbone DP; Dang TP
    Cancer Res; 2007 Sep; 67(17):8051-7. PubMed ID: 17804716
    [TBL] [Abstract][Full Text] [Related]  

  • 4. De novo discovery of a gamma-secretase inhibitor response signature using a novel in vivo breast tumor model.
    Watters JW; Cheng C; Majumder PK; Wang R; Yalavarthi S; Meeske C; Kong L; Sun W; Lin J; Heyer J; Ware C; Winter C; Reilly JF; Demuth T; Clark S; Chiu MI; Robinson MO; Kohl N; Kannan K
    Cancer Res; 2009 Dec; 69(23):8949-57. PubMed ID: 19903844
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation.
    Grudzien P; Lo S; Albain KS; Robinson P; Rajan P; Strack PR; Golde TE; Miele L; Foreman KE
    Anticancer Res; 2010 Oct; 30(10):3853-67. PubMed ID: 21036696
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification of tumorsphere- and tumor-initiating cells in HER2/Neu-induced mammary tumors.
    Liu JC; Deng T; Lehal RS; Kim J; Zacksenhaus E
    Cancer Res; 2007 Sep; 67(18):8671-81. PubMed ID: 17875707
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models.
    Mizuma M; Rasheed ZA; Yabuuchi S; Omura N; Campbell NR; de Wilde RF; De Oliveira E; Zhang Q; Puig O; Matsui W; Hidalgo M; Maitra A; Rajeshkumar NV
    Mol Cancer Ther; 2012 Sep; 11(9):1999-2009. PubMed ID: 22752426
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors.
    Fan X; Matsui W; Khaki L; Stearns D; Chun J; Li YM; Eberhart CG
    Cancer Res; 2006 Aug; 66(15):7445-52. PubMed ID: 16885340
    [TBL] [Abstract][Full Text] [Related]  

  • 9. z-Leucinyl-leucinyl-norleucinal induces apoptosis of human glioblastoma tumor-initiating cells by proteasome inhibition and mitotic arrest response.
    Monticone M; Biollo E; Fabiano A; Fabbi M; Daga A; Romeo F; Maffei M; Melotti A; Giaretti W; Corte G; Castagnola P
    Mol Cancer Res; 2009 Nov; 7(11):1822-34. PubMed ID: 19861404
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Gamma-secretase inhibition attenuates oxaliplatin-induced apoptosis through increased Mcl-1 and/or Bcl-xL in human colon cancer cells.
    Timme CR; Gruidl M; Yeatman TJ
    Apoptosis; 2013 Oct; 18(10):1163-74. PubMed ID: 23887890
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling.
    Lewis HD; Leveridge M; Strack PR; Haldon CD; O'neil J; Kim H; Madin A; Hannam JC; Look AT; Kohl N; Draetta G; Harrison T; Kerby JA; Shearman MS; Beher D
    Chem Biol; 2007 Feb; 14(2):209-19. PubMed ID: 17317574
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Rational targeting of Notch signaling in cancer.
    Rizzo P; Osipo C; Foreman K; Golde T; Osborne B; Miele L
    Oncogene; 2008 Sep; 27(38):5124-31. PubMed ID: 18758481
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis.
    Dey JH; Bianchi F; Voshol J; Bonenfant D; Oakeley EJ; Hynes NE
    Cancer Res; 2010 May; 70(10):4151-62. PubMed ID: 20460524
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis.
    Vaillant F; Asselin-Labat ML; Shackleton M; Forrest NC; Lindeman GJ; Visvader JE
    Cancer Res; 2008 Oct; 68(19):7711-7. PubMed ID: 18829523
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Metformin selectively targets tumor-initiating cells in ErbB2-overexpressing breast cancer models.
    Zhu P; Davis M; Blackwelder AJ; Bachman N; Liu B; Edgerton S; Williams LL; Thor AD; Yang X
    Cancer Prev Res (Phila); 2014 Feb; 7(2):199-210. PubMed ID: 24322659
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Tyrosine kinase inhibitor emodin suppresses growth of HER-2/neu-overexpressing breast cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxel.
    Zhang L; Lau YK; Xia W; Hortobagyi GN; Hung MC
    Clin Cancer Res; 1999 Feb; 5(2):343-53. PubMed ID: 10037184
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Introduction of SV40ER and hTERT into mammospheres generates breast cancer cells with stem cell properties.
    Paranjape AN; Mandal T; Mukherjee G; Kumar MV; Sengupta K; Rangarajan A
    Oncogene; 2012 Apr; 31(15):1896-909. PubMed ID: 21874052
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence.
    Pandya K; Meeke K; Clementz AG; Rogowski A; Roberts J; Miele L; Albain KS; Osipo C
    Br J Cancer; 2011 Sep; 105(6):796-806. PubMed ID: 21847123
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Preferential killing of breast tumor initiating cells by N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine/tesmilifene.
    Deng T; Liu JC; Pritchard KI; Eisen A; Zacksenhaus E
    Clin Cancer Res; 2009 Jan; 15(1):119-30. PubMed ID: 19118039
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors.
    Cho RW; Wang X; Diehn M; Shedden K; Chen GY; Sherlock G; Gurney A; Lewicki J; Clarke MF
    Stem Cells; 2008 Feb; 26(2):364-71. PubMed ID: 17975224
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.