BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

446 related articles for article (PubMed ID: 21670468)

  • 1. Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.
    Tatarek J; Cullion K; Ashworth T; Gerstein R; Aster JC; Kelliher MA
    Blood; 2011 Aug; 118(6):1579-90. PubMed ID: 21670468
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.
    Tremblay M; Tremblay CS; Herblot S; Aplan PD; Hébert J; Perreault C; Hoang T
    Genes Dev; 2010 Jun; 24(11):1093-105. PubMed ID: 20516195
    [TBL] [Abstract][Full Text] [Related]  

  • 3. SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells.
    Gerby B; Tremblay CS; Tremblay M; Rojas-Sutterlin S; Herblot S; Hébert J; Sauvageau G; Lemieux S; Lécuyer E; Veiga DF; Hoang T
    PLoS Genet; 2014 Dec; 10(12):e1004768. PubMed ID: 25522233
    [TBL] [Abstract][Full Text] [Related]  

  • 4. ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer.
    Thoms JA; Birger Y; Foster S; Knezevic K; Kirschenbaum Y; Chandrakanthan V; Jonquieres G; Spensberger D; Wong JW; Oram SH; Kinston SJ; Groner Y; Lock R; MacKenzie KL; Göttgens B; Izraeli S; Pimanda JE
    Blood; 2011 Jun; 117(26):7079-89. PubMed ID: 21536859
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies.
    Treanor LM; Volanakis EJ; Zhou S; Lu T; Sherr CJ; Sorrentino BP
    Blood; 2011 May; 117(20):5453-62. PubMed ID: 21427293
    [TBL] [Abstract][Full Text] [Related]  

  • 6. NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia.
    Kusy S; Gerby B; Goardon N; Gault N; Ferri F; Gérard D; Armstrong F; Ballerini P; Cayuela JM; Baruchel A; Pflumio F; Roméo PH
    J Exp Med; 2010 Sep; 207(10):2141-56. PubMed ID: 20855495
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice.
    Draheim KM; Hermance N; Yang Y; Arous E; Calvo J; Kelliher MA
    Oncogene; 2011 Mar; 30(10):1252-60. PubMed ID: 21057528
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Targeting the Notch1 and mTOR pathways in a mouse T-ALL model.
    Cullion K; Draheim KM; Hermance N; Tammam J; Sharma VM; Ware C; Nikov G; Krishnamoorthy V; Majumder PK; Kelliher MA
    Blood; 2009 Jun; 113(24):6172-81. PubMed ID: 19246562
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL.
    McCormack MP; Shields BJ; Jackson JT; Nasa C; Shi W; Slater NJ; Tremblay CS; Rabbitts TH; Curtis DJ
    Blood; 2013 Sep; 122(12):2093-103. PubMed ID: 23926305
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal.
    McCormack MP; Young LF; Vasudevan S; de Graaf CA; Codrington R; Rabbitts TH; Jane SM; Curtis DJ
    Science; 2010 Feb; 327(5967):879-83. PubMed ID: 20093438
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The role of quiescent thymic progenitors in TAL/LMO2-induced T-ALL chemotolerance.
    O'Connor KW; Kishimoto K; Kuzma IO; Wagner KP; Selway JS; Roderick JE; Karna KK; Gallagher KM; Hu K; Liu H; Li R; Brehm MA; Zhu LJ; Curtis DJ; Tremblay CS; Kelliher MA
    Leukemia; 2024 May; 38(5):951-962. PubMed ID: 38553571
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure of the leukemia oncogene LMO2: implications for the assembly of a hematopoietic transcription factor complex.
    El Omari K; Hoosdally SJ; Tuladhar K; Karia D; Vyas P; Patient R; Porcher C; Mancini EJ
    Blood; 2011 Feb; 117(7):2146-56. PubMed ID: 21076045
    [TBL] [Abstract][Full Text] [Related]  

  • 13. High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.
    Gerby B; Veiga DF; Krosl J; Nourreddine S; Ouellette J; Haman A; Lavoie G; Fares I; Tremblay M; Litalien V; Ottoni E; Kosic M; Geoffrion D; Ryan J; Maddox PS; Chagraoui J; Marinier A; Hébert J; Sauvageau G; Kwok BH; Roux PP; Hoang T
    J Clin Invest; 2016 Dec; 126(12):4569-4584. PubMed ID: 27797342
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Activating Notch1 mutations in mouse models of T-ALL.
    O'Neil J; Calvo J; McKenna K; Krishnamoorthy V; Aster JC; Bassing CH; Alt FW; Kelliher M; Look AT
    Blood; 2006 Jan; 107(2):781-5. PubMed ID: 16166587
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia.
    Mansour MR; Sanda T; Lawton LN; Li X; Kreslavsky T; Novina CD; Brand M; Gutierrez A; Kelliher MA; Jamieson CH; von Boehmer H; Young RA; Look AT
    J Exp Med; 2013 Jul; 210(8):1545-57. PubMed ID: 23857984
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Monoallelic
    Veiga DFT; Tremblay M; Gerby B; Herblot S; Haman A; Gendron P; Lemieux S; Zúñiga-Pflücker JC; Hébert J; Cohen JP; Hoang T
    Front Immunol; 2022; 13():867443. PubMed ID: 35401501
    [TBL] [Abstract][Full Text] [Related]  

  • 17. p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis.
    Fasseu M; Aplan PD; Chopin M; Boissel N; Bories JC; Soulier J; von Boehmer H; Sigaux F; Regnault A
    Blood; 2007 Oct; 110(7):2610-9. PubMed ID: 17507663
    [TBL] [Abstract][Full Text] [Related]  

  • 18. NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches.
    Ma W; Gutierrez A; Goff DJ; Geron I; Sadarangani A; Jamieson CA; Court AC; Shih AY; Jiang Q; Wu CC; Li K; Smith KM; Crews LA; Gibson NW; Deichaite I; Morris SR; Wei P; Carson DA; Look AT; Jamieson CH
    PLoS One; 2012; 7(6):e39725. PubMed ID: 22768113
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Notch1 gene mutations target KRAS G12D-expressing CD8+ cells and contribute to their leukemogenic transformation.
    Kong G; Du J; Liu Y; Meline B; Chang YI; Ranheim EA; Wang J; Zhang J
    J Biol Chem; 2013 Jun; 288(25):18219-27. PubMed ID: 23673656
    [TBL] [Abstract][Full Text] [Related]  

  • 20. SCL/TAL1: a multifaceted regulator from blood development to disease.
    Porcher C; Chagraoui H; Kristiansen MS
    Blood; 2017 Apr; 129(15):2051-2060. PubMed ID: 28179281
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.