BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

323 related articles for article (PubMed ID: 21673131)

  • 1. In vitro characterization of the metabolic pathways and cytochrome P450 inhibition and induction potential of BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor.
    Hong H; Su H; Ma L; Yao M; Iyer RA; Humphreys WG; Christopher LJ
    Drug Metab Dispos; 2011 Sep; 39(9):1658-67. PubMed ID: 21673131
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar.
    Zhang D; Wang L; Chandrasena G; Ma L; Zhu M; Zhang H; Davis CD; Humphreys WG
    Drug Metab Dispos; 2007 Jan; 35(1):139-49. PubMed ID: 17062778
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Metabolism and disposition of [14C]BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor, after oral administration to humans.
    Christopher LJ; Hong H; Vakkalagadda BJ; Clemens PL; Su H; Roongta V; Allentoff A; Sun H; Heller K; Harbison CT; Iyer RA; Humphreys WG; Wong T; Zhang S
    Drug Metab Dispos; 2010 Nov; 38(11):2049-59. PubMed ID: 20668249
    [TBL] [Abstract][Full Text] [Related]  

  • 4. In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies.
    Wang L; Zhang D; Raghavan N; Yao M; Ma L; Frost CE; Maxwell BD; Chen SY; He K; Goosen TC; Humphreys WG; Grossman SJ
    Drug Metab Dispos; 2010 Mar; 38(3):448-58. PubMed ID: 19940026
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Metabolism of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): identification of an unusual N-acetylglucosamine conjugate in the cynomolgus monkey.
    Johnson BM; Kamath AV; Leet JE; Liu X; Bhide RS; Tejwani RW; Zhang Y; Qian L; Wei DD; Lombardo LJ; Shu YZ
    Drug Metab Dispos; 2008 Dec; 36(12):2475-83. PubMed ID: 18787055
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mechanistic studies on a P450-mediated rearrangement of BMS-690514: conversion of a pyrrolotriazine to a hydroxypyridotriazine.
    Hong H; Caceres-Cortes J; Su H; Huang X; Roongta V; Bonacorsi S; Hong Y; Tian Y; Iyer RA; Humphreys WG; Christopher LJ
    Chem Res Toxicol; 2011 Jan; 24(1):125-34. PubMed ID: 21080678
    [TBL] [Abstract][Full Text] [Related]  

  • 7. In vitro evaluation of potential drug-drug interactions with ticagrelor: cytochrome P450 reaction phenotyping, inhibition, induction, and differential kinetics.
    Zhou D; Andersson TB; Grimm SW
    Drug Metab Dispos; 2011 Apr; 39(4):703-10. PubMed ID: 21177984
    [TBL] [Abstract][Full Text] [Related]  

  • 8. AM-2201 Inhibits Multiple Cytochrome P450 and Uridine 5'-Diphospho-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes.
    Kim JH; Kwon SS; Kong TY; Cheong JC; Kim HS; In MK; Lee HS
    Molecules; 2017 Mar; 22(3):. PubMed ID: 28287454
    [TBL] [Abstract][Full Text] [Related]  

  • 9. In vitro evaluation of the interaction potential of irosustat with drug-metabolizing enzymes.
    Ventura V; Solà J; Peraire C; Brée F; Obach R
    Drug Metab Dispos; 2012 Jul; 40(7):1268-78. PubMed ID: 22451700
    [TBL] [Abstract][Full Text] [Related]  

  • 10. In vitro hepatic metabolism of cediranib, a potent vascular endothelial growth factor tyrosine kinase inhibitor: interspecies comparison and human enzymology.
    Schulz-Utermoehl T; Spear M; Pollard CR; Pattison C; Rollison H; Sarda S; Ward M; Bushby N; Jordan A; Harrison M
    Drug Metab Dispos; 2010 Oct; 38(10):1688-97. PubMed ID: 20634336
    [TBL] [Abstract][Full Text] [Related]  

  • 11. In vitro inhibition of human liver cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes by rose bengal: system-dependent effects on inhibitory potential.
    Kazmi F; Haupt LJ; Horkman JR; Smith BD; Buckley DB; Wachter EA; Singer JM
    Xenobiotica; 2014 Jul; 44(7):606-14. PubMed ID: 24405273
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells.
    Reilly CA; Ehlhardt WJ; Jackson DA; Kulanthaivel P; Mutlib AE; Espina RJ; Moody DE; Crouch DJ; Yost GS
    Chem Res Toxicol; 2003 Mar; 16(3):336-49. PubMed ID: 12641434
    [TBL] [Abstract][Full Text] [Related]  

  • 13. In vitro metabolism of 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] acetic acid (licofelone, ML3000), an inhibitor of cyclooxygenase-1 and -2 and 5-lipoxygenase.
    Albrecht W; Unger A; Nussler AK; Laufer S
    Drug Metab Dispos; 2008 May; 36(5):894-903. PubMed ID: 18268076
    [TBL] [Abstract][Full Text] [Related]  

  • 14. In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes.
    Lapham K; Callegari E; Cianfrogna J; Lin J; Niosi M; Orozco CC; Sharma R; Goosen TC
    Drug Metab Dispos; 2020 Dec; 48(12):1350-1363. PubMed ID: 33020067
    [TBL] [Abstract][Full Text] [Related]  

  • 15. An in vitro evaluation of the victim and perpetrator potential of the anticancer agent laromustine (VNP40101M), based on reaction phenotyping and inhibition and induction of cytochrome P450 enzymes.
    Nassar AE; King I; Paris BL; Haupt L; Ndikum-Moffor F; Campbell R; Usuki E; Skibbe J; Brobst D; Ogilvie BW; Parkinson A
    Drug Metab Dispos; 2009 Sep; 37(9):1922-30. PubMed ID: 19520774
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Drug interaction potential of toremifene and N-desmethyltoremifene with multiple cytochrome P450 isoforms.
    Kim J; Peraire C; Solà J; Johanning KM; Dalton JT; Veverka KA
    Xenobiotica; 2011 Oct; 41(10):851-62. PubMed ID: 21726172
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Reevaluation of the microsomal metabolism of montelukast: major contribution by CYP2C8 at clinically relevant concentrations.
    Filppula AM; Laitila J; Neuvonen PJ; Backman JT
    Drug Metab Dispos; 2011 May; 39(5):904-11. PubMed ID: 21289076
    [TBL] [Abstract][Full Text] [Related]  

  • 18. [Investigation of metabolic kinetics and reaction phenotyping of ligustrazin by using liver microsomes and recombinant human enzymes].
    Tan Y; Zhuang XM; Shen GL; Li H; Gao Y
    Yao Xue Xue Bao; 2014 Mar; 49(3):374-9. PubMed ID: 24961110
    [TBL] [Abstract][Full Text] [Related]  

  • 19. In vitro assessment of cytochrome P450 inhibition and induction potential of tanespimycin and its major metabolite, 17-amino-17-demethoxygeldanamycin.
    Gan J; Liu-Kreyche P; Humphreys WG
    Cancer Chemother Pharmacol; 2012 Jan; 69(1):51-6. PubMed ID: 21594721
    [TBL] [Abstract][Full Text] [Related]  

  • 20. In vitro inhibition and induction of human cytochrome P450 enzymes by mirabegron, a potent and selective β3-adrenoceptor agonist.
    Takusagawa S; Miyashita A; Iwatsubo T; Usui T
    Xenobiotica; 2012 Dec; 42(12):1187-96. PubMed ID: 22834478
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.