BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

323 related articles for article (PubMed ID: 21673344)

  • 1. Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets.
    Schoenwaelder SM; Jarman KE; Gardiner EE; Hua M; Qiao J; White MJ; Josefsson EC; Alwis I; Ono A; Willcox A; Andrews RK; Mason KD; Salem HH; Huang DC; Kile BT; Roberts AW; Jackson SP
    Blood; 2011 Aug; 118(6):1663-74. PubMed ID: 21673344
    [TBL] [Abstract][Full Text] [Related]  

  • 2. BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation.
    Vogler M; Hamali HA; Sun XM; Bampton ET; Dinsdale D; Snowden RT; Dyer MJ; Goodall AH; Cohen GM
    Blood; 2011 Jun; 117(26):7145-54. PubMed ID: 21562047
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function.
    White MJ; Schoenwaelder SM; Josefsson EC; Jarman KE; Henley KJ; James C; Debrincat MA; Jackson SP; Huang DC; Kile BT
    Blood; 2012 May; 119(18):4283-90. PubMed ID: 22294729
    [TBL] [Abstract][Full Text] [Related]  

  • 4. BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets.
    Kodama T; Takehara T; Hikita H; Shimizu S; Shigekawa M; Li W; Miyagi T; Hosui A; Tatsumi T; Ishida H; Kanto T; Hiramatsu N; Yin XM; Hayashi N
    J Biol Chem; 2011 Apr; 286(16):13905-13. PubMed ID: 21367852
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Bcl-2 family proteins are essential for platelet survival.
    Zhang H; Nimmer PM; Tahir SK; Chen J; Fryer RM; Hahn KR; Iciek LA; Morgan SJ; Nasarre MC; Nelson R; Preusser LC; Reinhart GA; Smith ML; Rosenberg SH; Elmore SW; Tse C
    Cell Death Differ; 2007 May; 14(5):943-51. PubMed ID: 17205078
    [TBL] [Abstract][Full Text] [Related]  

  • 6. P2Y12 protects platelets from apoptosis via PI3k-dependent Bak/Bax inactivation.
    Zhang S; Ye J; Zhang Y; Xu X; Liu J; Zhang SH; Kunapuli SP; Ding Z
    J Thromb Haemost; 2013 Jan; 11(1):149-60. PubMed ID: 23140172
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Bcl-xL-inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function.
    Schoenwaelder SM; Jackson SP
    Blood; 2012 Feb; 119(5):1320-1; author reply 1321-2. PubMed ID: 22308285
    [No Abstract]   [Full Text] [Related]  

  • 8. Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells.
    Abed MN; Abdullah MI; Richardson A
    J Ovarian Res; 2016 Apr; 9():25. PubMed ID: 27080533
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inner Mitochondrial Membrane Disruption Links Apoptotic and Agonist-Initiated Phosphatidylserine Externalization in Platelets.
    Choo HJ; Kholmukhamedov A; Zhou C; Jobe S
    Arterioscler Thromb Vasc Biol; 2017 Aug; 37(8):1503-1512. PubMed ID: 28663253
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Comparison of putative BH3 mimetics AT-101, HA14-1, sabutoclax and TW-37 with ABT-737 in platelets.
    Wei H; Harper MT
    Platelets; 2021 Jan; 32(1):105-112. PubMed ID: 32079453
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Bcl-xL inhibition by molecular-targeting drugs sensitizes human pancreatic cancer cells to TRAIL.
    Hari Y; Harashima N; Tajima Y; Harada M
    Oncotarget; 2015 Dec; 6(39):41902-15. PubMed ID: 26506422
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Programmed anuclear cell death delimits platelet life span.
    Mason KD; Carpinelli MR; Fletcher JI; Collinge JE; Hilton AA; Ellis S; Kelly PN; Ekert PG; Metcalf D; Roberts AW; Huang DC; Kile BT
    Cell; 2007 Mar; 128(6):1173-86. PubMed ID: 17382885
    [TBL] [Abstract][Full Text] [Related]  

  • 13. BH3 mimetics inhibit growth of chondrosarcoma--a novel targeted-therapy for candidate models.
    Morii T; Ohtsuka K; Ohnishi H; Mochizuki K; Yoshiyama A; Aoyagi T; Hornicek FJ; Ichimura S
    Anticancer Res; 2014 Nov; 34(11):6423-30. PubMed ID: 25368242
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival.
    Debrincat MA; Josefsson EC; James C; Henley KJ; Ellis S; Lebois M; Betterman KL; Lane RM; Rogers KL; White MJ; Roberts AW; Harvey NL; Metcalf D; Kile BT
    Blood; 2012 Jun; 119(24):5850-8. PubMed ID: 22374700
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mcl-1 and Bcl-x
    Hockings C; Alsop AE; Fennell SC; Lee EF; Fairlie WD; Dewson G; Kluck RM
    Cell Death Differ; 2018 Mar; 25(4):721-734. PubMed ID: 29459767
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Role of platelet membrane glycoproteins Ib/IX and IIb/IIIa, and of platelet alpha-granule proteins in platelet aggregation induced by human osteosarcoma cells.
    Clezardin P; Drouin J; Morel-Kopp MC; Hanss M; Kehrel B; Serre CM; Kaplan C; Delmas PD
    Cancer Res; 1993 Oct; 53(19):4695-700. PubMed ID: 7691402
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Bcl-xL-inhibitory BH3 mimetic ABT-737 depletes platelet calcium stores.
    Harper MT; Poole AW
    Blood; 2012 May; 119(18):4337-8. PubMed ID: 22555663
    [No Abstract]   [Full Text] [Related]  

  • 18. Inhibiting GPIbα Shedding Preserves Post-Transfusion Recovery and Hemostatic Function of Platelets After Prolonged Storage.
    Chen W; Liang X; Syed AK; Jessup P; Church WR; Ware J; Josephson CD; Li R
    Arterioscler Thromb Vasc Biol; 2016 Sep; 36(9):1821-8. PubMed ID: 27417583
    [TBL] [Abstract][Full Text] [Related]  

  • 19. BH3-mimetic ABT-737 induces strong mitochondrial membrane depolarization in platelets but only weakly stimulates apoptotic morphological changes, platelet shrinkage and microparticle formation.
    Gyulkhandanyan AV; Mutlu A; Allen DJ; Freedman J; Leytin V
    Thromb Res; 2014 Jan; 133(1):73-9. PubMed ID: 24268298
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The Bcl-2/Bcl-XL inhibitor ABT-737 promotes death of retinoblastoma cancer cells.
    Allaman-Pillet N; Oberson A; Munier F; Schorderet DF
    Ophthalmic Genet; 2013; 34(1-2):1-13. PubMed ID: 21955141
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.