BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

303 related articles for article (PubMed ID: 21678907)

  • 1. Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
    Andaloussi M; Henriksson LM; Więckowska A; Lindh M; Björkelid C; Larsson AM; Suresh S; Iyer H; Srinivasa BR; Bergfors T; Unge T; Mowbray SL; Larhed M; Jones TA; Karlén A
    J Med Chem; 2011 Jul; 54(14):4964-76. PubMed ID: 21678907
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and evaluation of alpha,beta-unsaturated alpha-aryl-substituted fosmidomycin analogues as DXR inhibitors.
    Devreux V; Wiesner J; Jomaa H; Van der Eycken J; Van Calenbergh S
    Bioorg Med Chem Lett; 2007 Sep; 17(17):4920-3. PubMed ID: 17583502
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: an attempt to improve the activity against Mycobacterium tuberculosis.
    Andaloussi M; Lindh M; Björkelid C; Suresh S; Wieckowska A; Iyer H; Karlén A; Larhed M
    Bioorg Med Chem Lett; 2011 Sep; 21(18):5403-7. PubMed ID: 21824775
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A high-throughput screening assay for simultaneous selection of inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate synthase (Dxs) or 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr).
    Humnabadkar V; Jha RK; Ghatnekar N; De Sousa SM
    J Biomol Screen; 2011 Mar; 16(3):303-12. PubMed ID: 21335601
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
    Woo YH; Fernandes RP; Proteau PJ
    Bioorg Med Chem; 2006 Apr; 14(7):2375-85. PubMed ID: 16310360
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase from the hyperthermophile Thermotoga maritima for insights into the coordination of conformational changes and an inhibitor binding.
    Takenoya M; Ohtaki A; Noguchi K; Endo K; Sasaki Y; Ohsawa K; Yajima S; Yohda M
    J Struct Biol; 2010 Jun; 170(3):532-9. PubMed ID: 20353826
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation.
    Mac Sweeney A; Lange R; Fernandes RP; Schulz H; Dale GE; Douangamath A; Proteau PJ; Oefner C
    J Mol Biol; 2005 Jan; 345(1):115-27. PubMed ID: 15567415
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A fragment-based approach to understanding inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
    Mercklé L; de Andrés-Gómez A; Dick B; Cox RJ; Godfrey CR
    Chembiochem; 2005 Oct; 6(10):1866-74. PubMed ID: 16116659
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Studies addressing the importance of charge in the binding of fosmidomycin-like molecules to deoxyxylulosephosphate reductoisomerase.
    Perruchon J; Ortmann R; Altenkämper M; Silber K; Wiesner J; Jomaa H; Klebe G; Schlitzer M
    ChemMedChem; 2008 Aug; 3(8):1232-41. PubMed ID: 18470849
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis of functionalized cinnamaldehyde derivatives by an oxidative Heck reaction and their use as starting materials for preparation of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors.
    Nordqvist A; Björkelid C; Andaloussi M; Jansson AM; Mowbray SL; Karlén A; Larhed M
    J Org Chem; 2011 Nov; 76(21):8986-98. PubMed ID: 21936546
    [TBL] [Abstract][Full Text] [Related]  

  • 11. AFMoC enhances predictivity of 3D QSAR: a case study with DOXP-reductoisomerase.
    Silber K; Heidler P; Kurz T; Klebe G
    J Med Chem; 2005 May; 48(10):3547-63. PubMed ID: 15887963
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 1-Deoxy-D-xylulose 5-phosphate reductoisomerase: an overview.
    Proteau PJ
    Bioorg Chem; 2004 Dec; 32(6):483-93. PubMed ID: 15530989
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Reverse
    Abdullaziz MA; Takada S; Illarionov B; Pessanha de Carvalho L; Sakamoto Y; Höfmann S; Knak T; Kiffe-Delf AL; Mazzone F; Pfeffer K; Kalscheuer R; Bacher A; Held J; Fischer M; Tanaka N; Kurz T
    ACS Infect Dis; 2024 May; 10(5):1739-1752. PubMed ID: 38647213
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Novel deoxyxylulosephosphate-reductoisomerase inhibitors: fosmidomycin derivatives with spacious acyl residues.
    Ortmann R; Wiesner J; Silber K; Klebe G; Jomaa H; Schlitzer M
    Arch Pharm (Weinheim); 2007 Sep; 340(9):483-90. PubMed ID: 17806130
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
    Deng L; Sundriyal S; Rubio V; Shi ZZ; Song Y
    J Med Chem; 2009 Nov; 52(21):6539-42. PubMed ID: 19888756
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr).
    Behrendt CT; Kunfermann A; Illarionova V; Matheeussen A; Pein MK; Gräwert T; Kaiser J; Bacher A; Eisenreich W; Illarionov B; Fischer M; Maes L; Groll M; Kurz T
    J Med Chem; 2011 Oct; 54(19):6796-802. PubMed ID: 21866890
    [TBL] [Abstract][Full Text] [Related]  

  • 17. α-Substituted β-oxa isosteres of fosmidomycin: synthesis and biological evaluation.
    Brücher K; Illarionov B; Held J; Tschan S; Kunfermann A; Pein MK; Bacher A; Gräwert T; Maes L; Mordmüller B; Fischer M; Kurz T
    J Med Chem; 2012 Jul; 55(14):6566-75. PubMed ID: 22731758
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Crystallographic structures of two bisphosphonate:1-deoxyxylulose-5-phosphate reductoisomerase complexes.
    Yajima S; Hara K; Sanders JM; Yin F; Ohsawa K; Wiesner J; Jomaa H; Oldfield E
    J Am Chem Soc; 2004 Sep; 126(35):10824-5. PubMed ID: 15339150
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and bioactivity of β-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
    Chofor R; Sooriyaarachchi S; Risseeuw MD; Bergfors T; Pouyez J; Johny C; Haymond A; Everaert A; Dowd CS; Maes L; Coenye T; Alex A; Couch RD; Jones TA; Wouters J; Mowbray SL; Van Calenbergh S
    J Med Chem; 2015 Apr; 58(7):2988-3001. PubMed ID: 25781377
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structural studies on Mycobacterium tuberculosis DXR in complex with the antibiotic FR-900098.
    Björkelid C; Bergfors T; Unge T; Mowbray SL; Jones TA
    Acta Crystallogr D Biol Crystallogr; 2012 Feb; 68(Pt 2):134-43. PubMed ID: 22281742
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.