BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

156 related articles for article (PubMed ID: 21679375)

  • 21. Discovery of new β-D-glucosidase inhibitors via pharmacophore modeling and QSAR analysis followed by in silico screening.
    Abu Khalaf R; Abdula AM; Mubarak MS; Taha MO
    J Mol Model; 2011 Mar; 17(3):443-64. PubMed ID: 20490878
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function.
    Schormann N; Senkovich O; Walker K; Wright DL; Anderson AC; Rosowsky A; Ananthan S; Shinkre B; Velu S; Chattopadhyay D
    Proteins; 2008 Dec; 73(4):889-901. PubMed ID: 18536013
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Elaborate ligand-based modeling and subsequent synthetic exploration unveil new nanomolar Ca2+/calmodulin-dependent protein kinase II inhibitory leads.
    Shahin R; Taha MO
    Bioorg Med Chem; 2012 Jan; 20(1):377-400. PubMed ID: 22112539
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Extensive ligand-based modeling and in silico screening reveal nanomolar inducible nitric oxide synthase (iNOS) inhibitors.
    Suaifan GA; Shehadehh M; Al-Ijel H; Taha MO
    J Mol Graph Model; 2012 Jul; 37():1-26. PubMed ID: 22609742
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Discovery of novel CDK1 inhibitors by combining pharmacophore modeling, QSAR analysis and in silico screening followed by in vitro bioassay.
    Al-Sha'er MA; Taha MO
    Eur J Med Chem; 2010 Sep; 45(9):4316-30. PubMed ID: 20638755
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Discovery of potent adenosine A2a antagonists as potential anti-Parkinson disease agents. Non-linear QSAR analyses integrated with pharmacophore modeling.
    Khanfar MA; Al-Qtaishat S; Habash M; Taha MO
    Chem Biol Interact; 2016 Jul; 254():93-101. PubMed ID: 27216633
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Novel inhibitors of human histone deacetylase (HDAC) identified by QSAR modeling of known inhibitors, virtual screening, and experimental validation.
    Tang H; Wang XS; Huang XP; Roth BL; Butler KV; Kozikowski AP; Jung M; Tropsha A
    J Chem Inf Model; 2009 Feb; 49(2):461-76. PubMed ID: 19182860
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Selective peptidic and peptidomimetic inhibitors of Candida albicans myristoylCoA: protein N-myristoyltransferase: a new approach to antifungal therapy.
    Sikorski JA; Devadas B; Zupec ME; Freeman SK; Brown DL; Lu HF; Nagarajan S; Mehta PP; Wade AC; Kishore NS; Bryant ML; Getman DP; McWherter CA; Gordon JI
    Biopolymers; 1997; 43(1):43-71. PubMed ID: 9174411
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Current state of three-dimensional characterisation of antifungal targets and its use for molecular modelling in drug design.
    Ruge E; Korting HC; Borelli C
    Int J Antimicrob Agents; 2005 Dec; 26(6):427-41. PubMed ID: 16289513
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Ligand-based modelling followed by synthetic exploration unveil novel glycogen phosphorylase inhibitory leads.
    Habash M; Taha MO
    Bioorg Med Chem; 2011 Aug; 19(16):4746-71. PubMed ID: 21788139
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Modeling robust QSAR. 1. Coding molecules in 3D-QSAR--from a point to surface sectors and molecular volumes.
    Gieleciak R; Magdziarz T; Bak A; Polanski J
    J Chem Inf Model; 2005; 45(5):1447-55. PubMed ID: 16180922
    [TBL] [Abstract][Full Text] [Related]  

  • 32. 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment.
    Chen Y; Li H; Tang W; Zhu C; Jiang Y; Zou J; Yu Q; You Q
    Eur J Med Chem; 2009 Jul; 44(7):2868-76. PubMed ID: 19136179
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Identification of ligand features essential for HDACs inhibitors by pharmacophore modeling.
    Chen YD; Jiang YJ; Zhou JW; Yu QS; You QD
    J Mol Graph Model; 2008 Apr; 26(7):1160-8. PubMed ID: 18061500
    [TBL] [Abstract][Full Text] [Related]  

  • 34. [N-myristoyltransferase: a novel antifungal target].
    Zhu J; Sheng CQ; Zhang WN
    Yao Xue Xue Bao; 2005 Sep; 40(9):775-81. PubMed ID: 16342675
    [No Abstract]   [Full Text] [Related]  

  • 35. Pharmacophore modeling, quantitative structure-activity relationship analysis, and in silico screening reveal potent glycogen synthase kinase-3beta inhibitory activities for cimetidine, hydroxychloroquine, and gemifloxacin.
    Taha MO; Bustanji Y; Al-Ghussein MA; Mohammad M; Zalloum H; Al-Masri IM; Atallah N
    J Med Chem; 2008 Apr; 51(7):2062-77. PubMed ID: 18324764
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Discovery of new selective cytotoxic agents against Bcl-2 expressing cancer cells using ligand-based modeling.
    Aboalhaija NH; Zihlif MA; Taha MO
    Chem Biol Interact; 2016 Apr; 250():12-26. PubMed ID: 26954606
    [TBL] [Abstract][Full Text] [Related]  

  • 37. 3D-QSAR and receptor modeling of tyrosine kinase inhibitors with flexible atom receptor model (FLARM).
    Peng T; Pei J; Zhou J
    J Chem Inf Comput Sci; 2003; 43(1):298-303. PubMed ID: 12546565
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Discovery of new nanomolar peroxisome proliferator-activated receptor γ activators via elaborate ligand-based modeling.
    Al-Najjar BO; Wahab HA; Tengku Muhammad TS; Shu-Chien AC; Ahmad Noruddin NA; Taha MO
    Eur J Med Chem; 2011 Jun; 46(6):2513-29. PubMed ID: 21482446
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Structure-based quantitative structure--activity relationship modeling of estrogen receptor β-ligands.
    Dong X; Hilliard SG; Zheng W
    Future Med Chem; 2011 Jun; 3(8):933-45. PubMed ID: 21707397
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Ligand-based assessment of factor Xa binding site flexibility via elaborate pharmacophore exploration and genetic algorithm-based QSAR modeling.
    Taha MO; Qandil AM; Zaki DD; AlDamen MA
    Eur J Med Chem; 2005 Jul; 40(7):701-27. PubMed ID: 15935905
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.