These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

162 related articles for article (PubMed ID: 21680182)

  • 21. Interaction of a cyclic, bivalent smac mimetic with the x-linked inhibitor of apoptosis protein.
    Nikolovska-Coleska Z; Meagher JL; Jiang S; Yang CY; Qiu S; Roller PP; Stuckey JA; Wang S
    Biochemistry; 2008 Sep; 47(37):9811-24. PubMed ID: 18717598
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Effect of the XIAP inhibitor Embelin on TRAIL-induced apoptosis of pancreatic cancer cells.
    Mori T; Doi R; Kida A; Nagai K; Kami K; Ito D; Toyoda E; Kawaguchi Y; Uemoto S
    J Surg Res; 2007 Oct; 142(2):281-6. PubMed ID: 17640673
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Biophysical characterization of the interaction between the full-length XIAP and Smac/DIABLO.
    Polykretis P; Luchinat E
    Biochem Biophys Res Commun; 2021 Sep; 568():180-185. PubMed ID: 34247143
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.
    Zobel K; Wang L; Varfolomeev E; Franklin MC; Elliott LO; Wallweber HJ; Okawa DC; Flygare JA; Vucic D; Fairbrother WJ; Deshayes K
    ACS Chem Biol; 2006 Sep; 1(8):525-33. PubMed ID: 17168540
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Importance of ligand reorganization free energy in protein-ligand binding-affinity prediction.
    Yang CY; Sun H; Chen J; Nikolovska-Coleska Z; Wang S
    J Am Chem Soc; 2009 Sep; 131(38):13709-21. PubMed ID: 19736924
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.
    Vucic D; Franklin MC; Wallweber HJ; Das K; Eckelman BP; Shin H; Elliott LO; Kadkhodayan S; Deshayes K; Salvesen GS; Fairbrother WJ
    Biochem J; 2005 Jan; 385(Pt 1):11-20. PubMed ID: 15485396
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors.
    Wang J; Li W
    J Pharmacol Exp Ther; 2014 May; 349(2):319-29. PubMed ID: 24623800
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis.
    Welsh K; Milutinovic S; Ardecky RJ; Gonzalez-Lopez M; Ganji SR; Teriete P; Finlay D; Riedl S; Matsuzawa S; Pinilla C; Houghten R; Vuori K; Reed JC; Cosford ND
    PLoS One; 2016; 11(9):e0161952. PubMed ID: 27617834
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Structure-based design of potent, conformationally constrained Smac mimetics.
    Sun H; Nikolovska-Coleska Z; Yang CY; Xu L; Liu M; Tomita Y; Pan H; Yoshioka Y; Krajewski K; Roller PP; Wang S
    J Am Chem Soc; 2004 Dec; 126(51):16686-7. PubMed ID: 15612682
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Structure-activity based study of the Smac-binding pocket within the BIR3 domain of XIAP.
    Wist AD; Gu L; Riedl SJ; Shi Y; McLendon GL
    Bioorg Med Chem; 2007 Apr; 15(8):2935-43. PubMed ID: 17336535
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Smac/DIABLO release from mitochondria and XIAP inhibition are essential to limit clonogenicity of Type I tumor cells after TRAIL receptor stimulation.
    Maas C; Verbrugge I; de Vries E; Savich G; van de Kooij LW; Tait SW; Borst J
    Cell Death Differ; 2010 Oct; 17(10):1613-23. PubMed ID: 20395960
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Sensitization of human bladder tumor cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis with a small molecule IAP antagonist.
    Griffith TS; Kucaba TA; O'Donnell MA; Burns J; Benetatos C; McKinlay MA; Condon S; Chunduru S
    Apoptosis; 2011 Jan; 16(1):13-26. PubMed ID: 20734142
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro.
    MacFarlane M; Merrison W; Bratton SB; Cohen GM
    J Biol Chem; 2002 Sep; 277(39):36611-6. PubMed ID: 12121969
    [TBL] [Abstract][Full Text] [Related]  

  • 34. MnSOD protects colorectal cancer cells from TRAIL-induced apoptosis by inhibition of Smac/DIABLO release.
    Mohr A; Büneker C; Gough RP; Zwacka RM
    Oncogene; 2008 Jan; 27(6):763-74. PubMed ID: 17653087
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity.
    Sun H; Liu L; Lu J; Bai L; Li X; Nikolovska-Coleska Z; McEachern D; Yang CY; Qiu S; Yi H; Sun D; Wang S
    J Med Chem; 2011 May; 54(9):3306-18. PubMed ID: 21462933
    [TBL] [Abstract][Full Text] [Related]  

  • 36. X-linked inhibitor of apoptosis (XIAP) blocks Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of prostate cancer cells in the presence of mitochondrial activation: sensitization by overexpression of second mitochondria-derived activator of caspase/direct IAP-binding protein with low pl (Smac/DIABLO).
    Ng CP; Bonavida B
    Mol Cancer Ther; 2002 Oct; 1(12):1051-8. PubMed ID: 12481428
    [TBL] [Abstract][Full Text] [Related]  

  • 37. The activator of apoptosis Smac-DIABLO acts as a tetramer in solution.
    Mastrangelo E; Vachette P; Cossu F; Malvezzi F; Bolognesi M; Milani M
    Biophys J; 2015 Feb; 108(3):714-23. PubMed ID: 25650938
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein (XIAP)-mediated caspase inhibition by Smac.
    Huang Y; Rich RL; Myszka DG; Wu H
    J Biol Chem; 2003 Dec; 278(49):49517-22. PubMed ID: 14512414
    [TBL] [Abstract][Full Text] [Related]  

  • 39. A NMR and computational study of Smac mimics targeting both the BIR2 and BIR3 domains in XIAP protein.
    Potenza D; Belvisi L; Vasile F; Moroni E; Cossu F; Seneci P
    Org Biomol Chem; 2012 Apr; 10(16):3278-87. PubMed ID: 22407164
    [TBL] [Abstract][Full Text] [Related]  

  • 40. A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells.
    Bockbrader KM; Tan M; Sun Y
    Oncogene; 2005 Nov; 24(49):7381-8. PubMed ID: 16044155
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 9.