168 related articles for article (PubMed ID: 21683248)
1. The role of autophagy in alpha-1-antitrypsin deficiency.
Hidvegi T; Mukherjee A; Ewing M; Kemp C; Perlmutter DH
Methods Enzymol; 2011; 499():33-54. PubMed ID: 21683248
[TBL] [Abstract][Full Text] [Related]
2. Fasting in alpha1-antitrypsin deficient liver: constitutive [correction of consultative] activation of autophagy.
Teckman JH; An JK; Loethen S; Perlmutter DH
Am J Physiol Gastrointest Liver Physiol; 2002 Nov; 283(5):G1156-65. PubMed ID: 12381530
[TBL] [Abstract][Full Text] [Related]
3. Autophagic disposal of the aggregation-prone protein that causes liver inflammation and carcinogenesis in alpha-1-antitrypsin deficiency.
Perlmutter DH
Cell Death Differ; 2009 Jan; 16(1):39-45. PubMed ID: 18617899
[TBL] [Abstract][Full Text] [Related]
4. Alpha-1 antitrypsin and liver disease: mechanisms of injury and novel interventions.
Teckman JH; Mangalat N
Expert Rev Gastroenterol Hepatol; 2015 Feb; 9(2):261-8. PubMed ID: 25066184
[TBL] [Abstract][Full Text] [Related]
5. Mitochondrial autophagy and injury in the liver in alpha 1-antitrypsin deficiency.
Teckman JH; An JK; Blomenkamp K; Schmidt B; Perlmutter D
Am J Physiol Gastrointest Liver Physiol; 2004 May; 286(5):G851-62. PubMed ID: 14684378
[TBL] [Abstract][Full Text] [Related]
6. Fluphenazine reduces proteotoxicity in C. elegans and mammalian models of alpha-1-antitrypsin deficiency.
Li J; Pak SC; O'Reilly LP; Benson JA; Wang Y; Hidvegi T; Hale P; Dippold C; Ewing M; Silverman GA; Perlmutter DH
PLoS One; 2014; 9(1):e87260. PubMed ID: 24498058
[TBL] [Abstract][Full Text] [Related]
7. Alpha1-antitrypsin deficiency: liver disease associated with retention of a mutant secretory glycoprotein in the endoplasmic reticulum.
Perlmutter DH
Methods Mol Biol; 2003; 232():39-56. PubMed ID: 12840538
[No Abstract] [Full Text] [Related]
8. An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis.
Hidvegi T; Ewing M; Hale P; Dippold C; Beckett C; Kemp C; Maurice N; Mukherjee A; Goldbach C; Watkins S; Michalopoulos G; Perlmutter DH
Science; 2010 Jul; 329(5988):229-32. PubMed ID: 20522742
[TBL] [Abstract][Full Text] [Related]
9. Indomethacin increases liver damage in a murine model of liver injury from alpha-1-antitrypsin deficiency.
Rudnick DA; Shikapwashya O; Blomenkamp K; Teckman JH
Hepatology; 2006 Oct; 44(4):976-82. PubMed ID: 17006946
[TBL] [Abstract][Full Text] [Related]
10. FBG1 Is the Final Arbitrator of A1AT-Z Degradation.
Wen JH; Wen H; Gibson-Corley KN; Glenn KA
PLoS One; 2015; 10(8):e0135591. PubMed ID: 26295339
[TBL] [Abstract][Full Text] [Related]
11. Autophagy in liver diseases.
Rautou PE; Mansouri A; Lebrec D; Durand F; Valla D; Moreau R
J Hepatol; 2010 Dec; 53(6):1123-34. PubMed ID: 20810185
[TBL] [Abstract][Full Text] [Related]
12. Alpha-1-antitrypsin deficiency: a new paradigm for hepatocellular carcinoma in genetic liver disease.
Rudnick DA; Perlmutter DH
Hepatology; 2005 Sep; 42(3):514-21. PubMed ID: 16044402
[TBL] [Abstract][Full Text] [Related]
13. Multiple Genes Core to ERAD, Macroautophagy and Lysosomal Degradation Pathways Participate in the Proteostasis Response in α1-Antitrypsin Deficiency.
Li J; Moretti F; Hidvegi T; Sviben S; Fitzpatrick JAJ; Sundaramoorthi H; Pak SC; Silverman GA; Knapp B; Filipuzzi I; Alford J; Reece-Hoyes J; Nigsch F; Murphy LO; Nyfeler B; Perlmutter DH
Cell Mol Gastroenterol Hepatol; 2024; 17(6):1007-1024. PubMed ID: 38336172
[TBL] [Abstract][Full Text] [Related]
14. The role of autophagy in alpha-1-antitrypsin deficiency: a specific cellular response in genetic diseases associated with aggregation-prone proteins.
Perlmutter DH
Autophagy; 2006; 2(4):258-63. PubMed ID: 16874089
[TBL] [Abstract][Full Text] [Related]
15. Alpha-1-antitrypsin deficiency: importance of proteasomal and autophagic degradative pathways in disposal of liver disease-associated protein aggregates.
Perlmutter DH
Annu Rev Med; 2011; 62():333-45. PubMed ID: 20707674
[TBL] [Abstract][Full Text] [Related]
16. Alpha-1-antitrypsin deficiency: accumulation or degradation of mutant variants within the hepatic endoplasmic reticulum.
Sifers RN; Finegold MJ; Woo SL
Am J Respir Cell Mol Biol; 1989 Nov; 1(5):341-5. PubMed ID: 2700304
[TBL] [Abstract][Full Text] [Related]
17. Analyses of hepatocellular proliferation in a mouse model of alpha-1-antitrypsin deficiency.
Rudnick DA; Liao Y; An JK; Muglia LJ; Perlmutter DH; Teckman JH
Hepatology; 2004 Apr; 39(4):1048-55. PubMed ID: 15057909
[TBL] [Abstract][Full Text] [Related]
18. Capitalizing on the autophagic response for treatment of liver disease caused by alpha-1-antitrypsin deficiency and other genetic diseases.
Chu AS; Perlmutter DH; Wang Y
Biomed Res Int; 2014; 2014():459823. PubMed ID: 25025052
[TBL] [Abstract][Full Text] [Related]
19. Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-anti-trypsin deficiency.
Pastore N; Blomenkamp K; Annunziata F; Piccolo P; Mithbaokar P; Maria Sepe R; Vetrini F; Palmer D; Ng P; Polishchuk E; Iacobacci S; Polishchuk R; Teckman J; Ballabio A; Brunetti-Pierri N
EMBO Mol Med; 2013 Mar; 5(3):397-412. PubMed ID: 23381957
[TBL] [Abstract][Full Text] [Related]
20. Targeting intracellular degradation pathways for treatment of liver disease caused by α1-antitrypsin deficiency.
Wang Y; Perlmutter DH
Pediatr Res; 2014 Jan; 75(1-2):133-9. PubMed ID: 24226634
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]