BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

227 related articles for article (PubMed ID: 21685469)

  • 1. Multiple oligomerization domains of KANK1-PDGFRβ are required for JAK2-independent hematopoietic cell proliferation and signaling via STAT5 and ERK.
    Medves S; Noël LA; Montano-Almendras CP; Albu RI; Schoemans H; Constantinescu SN; Demoulin JB
    Haematologica; 2011 Oct; 96(10):1406-14. PubMed ID: 21685469
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Tel/PDGFRbeta induces stem cell differentiation via the Ras/ERK and STAT5 signaling pathways.
    Dobbin E; Graham C; Corrigan PM; Thomas KG; Freeburn RW; Wheadon H
    Exp Hematol; 2009 Jan; 37(1):111-121. PubMed ID: 19100521
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ectopic PD-L1 expression in JAK2 (V617F) myeloproliferative neoplasm patients is mediated via increased activation of STAT3 and STAT5.
    Guru SA; Sumi MP; Mir R; Waza AA; Bhat MA; Zuberi M; Lali P; Saxena A
    Hum Cell; 2020 Oct; 33(4):1099-1111. PubMed ID: 32430672
    [TBL] [Abstract][Full Text] [Related]  

  • 4. STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant.
    Funakoshi-Tago M; Tago K; Abe M; Sonoda Y; Kasahara T
    J Biol Chem; 2010 Feb; 285(8):5296-307. PubMed ID: 20028972
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Three Tyrosine Residues in the Erythropoietin Receptor Are Essential for Janus Kinase 2 V617F Mutant-induced Tumorigenesis.
    Ueda F; Tago K; Tamura H; Funakoshi-Tago M
    J Biol Chem; 2017 Feb; 292(5):1826-1846. PubMed ID: 27998978
    [TBL] [Abstract][Full Text] [Related]  

  • 6. pSTAT5 and ERK exhibit different expression in myeloproliferative neoplasms.
    Wiśniewska-Chudy E; Szylberg Ł; Dworacki G; Mizera-Nyczak E; Marszałek A
    Oncol Rep; 2017 Apr; 37(4):2295-2307. PubMed ID: 28260027
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The TEL-Jak2 oncoprotein induces Socs1 expression and altered cytokine response in Ba/F3 cells.
    Monni R; Santos SC; Mauchauffe M; Berger R; Ghysdael J; Gouilleux F; Gisselbrecht S; Bernard O; Penard-Lacronique V
    Oncogene; 2001 Feb; 20(7):849-58. PubMed ID: 11314018
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Phosphorylated CIS suppresses the Epo or JAK2 V617F mutant-triggered cell proliferation through binding to EpoR.
    Funakoshi-Tago M; Moriwaki T; Ueda F; Tamura H; Kasahara T; Tago K
    Cell Signal; 2017 Feb; 31():41-57. PubMed ID: 28038963
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The fusion proteins TEL-PDGFRbeta and FIP1L1-PDGFRalpha escape ubiquitination and degradation.
    Toffalini F; Kallin A; Vandenberghe P; Pierre P; Michaux L; Cools J; Demoulin JB
    Haematologica; 2009 Aug; 94(8):1085-93. PubMed ID: 19644140
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways.
    Guasch G; Ollendorff V; Borg JP; Birnbaum D; Pébusque MJ
    Mol Cell Biol; 2001 Dec; 21(23):8129-42. PubMed ID: 11689702
    [TBL] [Abstract][Full Text] [Related]  

  • 11. ETV6-PDGFRB and FIP1L1-PDGFRA stimulate human hematopoietic progenitor cell proliferation and differentiation into eosinophils: the role of nuclear factor-κB.
    Montano-Almendras CP; Essaghir A; Schoemans H; Varis I; Noël LA; Velghe AI; Latinne D; Knoops L; Demoulin JB
    Haematologica; 2012 Jul; 97(7):1064-72. PubMed ID: 22271894
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Heat shock protein 90 inhibitor is synergistic with JAK2 inhibitor and overcomes resistance to JAK2-TKI in human myeloproliferative neoplasm cells.
    Fiskus W; Verstovsek S; Manshouri T; Rao R; Balusu R; Venkannagari S; Rao NN; Ha K; Smith JE; Hembruff SL; Abhyankar S; McGuirk J; Bhalla KN
    Clin Cancer Res; 2011 Dec; 17(23):7347-58. PubMed ID: 21976548
    [TBL] [Abstract][Full Text] [Related]  

  • 13. TEL-JAK2 constitutively activates the extracellular signal-regulated kinase (ERK), stress-activated protein/Jun kinase (SAPK/JNK), and p38 signaling pathways.
    Ho JM; Nguyen MH; Dierov JK; Badger KM; Beattie BK; Tartaro P; Haq R; Zanke BW; Carroll MP; Barber DL
    Blood; 2002 Aug; 100(4):1438-48. PubMed ID: 12149229
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Transforming and tumorigenic activity of JAK2 by fusion to BCR: molecular mechanisms of action of a novel BCR-JAK2 tyrosine-kinase.
    Cuesta-Domínguez Á; Ortega M; Ormazábal C; Santos-Roncero M; Galán-Díez M; Steegmann JL; Figuera Á; Arranz E; Vizmanos JL; Bueren JA; Río P; Fernández-Ruiz E
    PLoS One; 2012; 7(2):e32451. PubMed ID: 22384256
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Transforming properties of chimeric TEL-JAK proteins in Ba/F3 cells.
    Lacronique V; Boureux A; Monni R; Dumon S; Mauchauffé M; Mayeux P; Gouilleux F; Berger R; Gisselbrecht S; Ghysdael J; Bernard OA
    Blood; 2000 Mar; 95(6):2076-83. PubMed ID: 10706877
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Critical role of the platelet-derived growth factor receptor (PDGFR) beta transmembrane domain in the TEL-PDGFRbeta cytosolic oncoprotein.
    Toffalini F; Hellberg C; Demoulin JB
    J Biol Chem; 2010 Apr; 285(16):12268-78. PubMed ID: 20164181
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Dnmt3a is downregulated by Stat5a and mediates G0/G1 arrest by suppressing the miR-17-5p/Cdkn1a axis in Jak2
    Zhou J; Guo C; Wu H; Li B; Zhou LL; Liang AB; Fu JF
    BMC Cancer; 2021 Nov; 21(1):1213. PubMed ID: 34773997
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Fusion of the ets transcription factor TEL to Jak2 results in constitutive Jak-Stat signaling.
    Ho JM; Beattie BK; Squire JA; Frank DA; Barber DL
    Blood; 1999 Jun; 93(12):4354-64. PubMed ID: 10361134
    [TBL] [Abstract][Full Text] [Related]  

  • 19. KANK1, a candidate tumor suppressor gene, is fused to PDGFRB in an imatinib-responsive myeloid neoplasm with severe thrombocythemia.
    Medves S; Duhoux FP; Ferrant A; Toffalini F; Ameye G; Libouton JM; Poirel HA; Demoulin JB
    Leukemia; 2010 May; 24(5):1052-5. PubMed ID: 20164854
    [No Abstract]   [Full Text] [Related]  

  • 20. Evidence for a role of NF-kappaB in the survival of hematopoietic cells mediated by interleukin 3 and the oncogenic TEL/platelet-derived growth factor receptor beta fusion protein.
    Besançon F; Atfi A; Gespach C; Cayre YE; Bourgeade MF
    Proc Natl Acad Sci U S A; 1998 Jul; 95(14):8081-6. PubMed ID: 9653143
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.