These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

279 related articles for article (PubMed ID: 21693539)

  • 1. Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells.
    Marconett CN; Sundar SN; Tseng M; Tin AS; Tran KQ; Mahuron KM; Bjeldanes LF; Firestone GL
    Carcinogenesis; 2011 Sep; 32(9):1315-23. PubMed ID: 21693539
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells.
    Nguyen HH; Lavrenov SN; Sundar SN; Nguyen DH; Tseng M; Marconett CN; Kung J; Staub RE; Preobrazhenskaya MN; Bjeldanes LF; Firestone GL
    Chem Biol Interact; 2010 Aug; 186(3):255-66. PubMed ID: 20570586
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Indole-3-carbinol selectively uncouples expression and activity of estrogen receptor subtypes in human breast cancer cells.
    Sundar SN; Kerekatte V; Equinozio CN; Doan VB; Bjeldanes LF; Firestone GL
    Mol Endocrinol; 2006 Dec; 20(12):3070-82. PubMed ID: 16901971
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells.
    Marconett CN; Singhal AK; Sundar SN; Firestone GL
    Mol Cell Endocrinol; 2012 Nov; 363(1-2):74-84. PubMed ID: 22835548
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter.
    Cram EJ; Liu BD; Bjeldanes LF; Firestone GL
    J Biol Chem; 2001 Jun; 276(25):22332-40. PubMed ID: 11297539
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling.
    Cover CM; Hsieh SJ; Tran SH; Hallden G; Kim GS; Bjeldanes LF; Firestone GL
    J Biol Chem; 1998 Feb; 273(7):3838-47. PubMed ID: 9461564
    [TBL] [Abstract][Full Text] [Related]  

  • 7. N-Alkoxy derivatization of indole-3-carbinol increases the efficacy of the G1 cell cycle arrest and of I3C-specific regulation of cell cycle gene transcription and activity in human breast cancer cells.
    Jump SM; Kung J; Staub R; Kinseth MA; Cram EJ; Yudina LN; Preobrazhenskaya MN; Bjeldanes LF; Firestone GL
    Biochem Pharmacol; 2008 Feb; 75(3):713-24. PubMed ID: 18023427
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Indole-3-carbinol and 3-3'-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter-Sp1 transcription factor interactions.
    Firestone GL; Bjeldanes LF
    J Nutr; 2003 Jul; 133(7 Suppl):2448S-2455S. PubMed ID: 12840223
    [TBL] [Abstract][Full Text] [Related]  

  • 9. 3,3'-Diindolylmethane (DIM) induces a G(1) cell cycle arrest in human breast cancer cells that is accompanied by Sp1-mediated activation of p21(WAF1/CIP1) expression.
    Hong C; Kim HA; Firestone GL; Bjeldanes LF
    Carcinogenesis; 2002 Aug; 23(8):1297-305. PubMed ID: 12151347
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Indole-3-carbinol induces a G1 cell cycle arrest and inhibits prostate-specific antigen production in human LNCaP prostate carcinoma cells.
    Zhang J; Hsu B A JC; Kinseth B A MA; Bjeldanes LF; Firestone GL
    Cancer; 2003 Dec; 98(11):2511-20. PubMed ID: 14635088
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Indole-3-carbinol inhibition of androgen receptor expression and downregulation of androgen responsiveness in human prostate cancer cells.
    Hsu JC; Zhang J; Dev A; Wing A; Bjeldanes LF; Firestone GL
    Carcinogenesis; 2005 Nov; 26(11):1896-904. PubMed ID: 15958518
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Indole-3-carbinol mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein.
    Hsu JC; Dev A; Wing A; Brew CT; Bjeldanes LF; Firestone GL
    Biochem Pharmacol; 2006 Dec; 72(12):1714-23. PubMed ID: 16970927
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A new indole-3-carbinol tetrameric derivative inhibits cyclin-dependent kinase 6 expression, and induces G1 cell cycle arrest in both estrogen-dependent and estrogen-independent breast cancer cell lines.
    Brandi G; Paiardini M; Cervasi B; Fiorucci C; Filippone P; De Marco C; Zaffaroni N; Magnani M
    Cancer Res; 2003 Jul; 63(14):4028-36. PubMed ID: 12874002
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells.
    Chinni SR; Li Y; Upadhyay S; Koppolu PK; Sarkar FH
    Oncogene; 2001 May; 20(23):2927-36. PubMed ID: 11420705
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Indole-3-carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)alpha protein degradation in breast cancer cells disrupting an ERalpha-GATA3 transcriptional cross-regulatory loop.
    Marconett CN; Sundar SN; Poindexter KM; Stueve TR; Bjeldanes LF; Firestone GL
    Mol Biol Cell; 2010 Apr; 21(7):1166-77. PubMed ID: 20130088
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells.
    Cover CM; Hsieh SJ; Cram EJ; Hong C; Riby JE; Bjeldanes LF; Firestone GL
    Cancer Res; 1999 Mar; 59(6):1244-51. PubMed ID: 10096555
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Target protein interactions of indole-3-carbinol and the highly potent derivative 1-benzyl-I3C with the C-terminal domain of human elastase uncouples cell cycle arrest from apoptotic signaling.
    Aronchik I; Chen T; Durkin KA; Horwitz MS; Preobrazhenskaya MN; Bjeldanes LF; Firestone GL
    Mol Carcinog; 2012 Nov; 51(11):881-94. PubMed ID: 22012859
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Indole-3-carbinol inhibits Sp1-induced matrix metalloproteinase-2 expression to attenuate migration and invasion of breast cancer cells.
    Hung WC; Chang HC
    J Agric Food Chem; 2009 Jan; 57(1):76-82. PubMed ID: 19061309
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Indole-3-carbinol is a negative regulator of estrogen receptor-alpha signaling in human tumor cells.
    Meng Q; Yuan F; Goldberg ID; Rosen EM; Auborn K; Fan S
    J Nutr; 2000 Dec; 130(12):2927-31. PubMed ID: 11110848
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells.
    Brew CT; Aronchik I; Hsu JC; Sheen JH; Dickson RB; Bjeldanes LF; Firestone GL
    Int J Cancer; 2006 Feb; 118(4):857-68. PubMed ID: 16152627
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.