BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

514 related articles for article (PubMed ID: 21695060)

  • 1. Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase.
    Hogl S; Kuhn PH; Colombo A; Lichtenthaler SF
    PLoS One; 2011; 6(6):e21337. PubMed ID: 21695060
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines.
    Colombo A; Wang H; Kuhn PH; Page R; Kremmer E; Dempsey PJ; Crawford HC; Lichtenthaler SF
    Neurobiol Dis; 2013 Jan; 49():137-47. PubMed ID: 22940630
    [TBL] [Abstract][Full Text] [Related]  

  • 3. η-Secretase processing of APP inhibits neuronal activity in the hippocampus.
    Willem M; Tahirovic S; Busche MA; Ovsepian SV; Chafai M; Kootar S; Hornburg D; Evans LD; Moore S; Daria A; Hampel H; Müller V; Giudici C; Nuscher B; Wenninger-Weinzierl A; Kremmer E; Heneka MT; Thal DR; Giedraitis V; Lannfelt L; Müller U; Livesey FJ; Meissner F; Herms J; Konnerth A; Marie H; Haass C
    Nature; 2015 Oct; 526(7573):443-7. PubMed ID: 26322584
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases.
    Endres K; Postina R; Schroeder A; Mueller U; Fahrenholz F
    FEBS J; 2005 Nov; 272(22):5808-20. PubMed ID: 16279945
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Insulin-like growth factor-1 (IGF-1)-induced processing of amyloid-beta precursor protein (APP) and APP-like protein 2 is mediated by different metalloproteinases.
    Jacobsen KT; Adlerz L; Multhaup G; Iverfeldt K
    J Biol Chem; 2010 Apr; 285(14):10223-31. PubMed ID: 20139073
    [TBL] [Abstract][Full Text] [Related]  

  • 6. ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons.
    Kuhn PH; Wang H; Dislich B; Colombo A; Zeitschel U; Ellwart JW; Kremmer E; Rossner S; Lichtenthaler SF
    EMBO J; 2010 Sep; 29(17):3020-32. PubMed ID: 20676056
    [TBL] [Abstract][Full Text] [Related]  

  • 7. APLP2 is predominantly cleaved by β-secretase and γ-secretase in the human brain.
    Yanagida K; Maruyama R; Tagami S; Kudo T; Okochi M; Fukumori A
    Psychogeriatrics; 2023 Mar; 23(2):311-318. PubMed ID: 36691315
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Proximity ligation assay reveals both pre- and postsynaptic localization of the APP-processing enzymes ADAM10 and BACE1 in rat and human adult brain.
    Lundgren JL; Vandermeulen L; Sandebring-Matton A; Ahmed S; Winblad B; Di Luca M; Tjernberg LO; Marcello E; Frykman S
    BMC Neurosci; 2020 Feb; 21(1):6. PubMed ID: 32019490
    [TBL] [Abstract][Full Text] [Related]  

  • 9. beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins.
    Sala Frigerio C; Fadeeva JV; Minogue AM; Citron M; Van Leuven F; Staufenbiel M; Paganetti P; Selkoe DJ; Walsh DM
    FEBS J; 2010 Mar; 277(6):1503-18. PubMed ID: 20163459
    [TBL] [Abstract][Full Text] [Related]  

  • 10. α-secretase ADAM10 physically interacts with β-secretase BACE1 in neurons and regulates CHL1 proteolysis.
    Wang X; Wang C; Pei G
    J Mol Cell Biol; 2018 Oct; 10(5):411-422. PubMed ID: 29325091
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Upregulation of APP, ADAM10 and ADAM17 in the denervated mouse dentate gyrus.
    Del Turco D; Schlaudraff J; Bonin M; Deller T
    PLoS One; 2014; 9(1):e84962. PubMed ID: 24404197
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Proteolytic cleavage of amyloid precursor protein by ADAM10 mediates proliferation and migration in breast cancer.
    Tsang JYS; Lee MA; Chan TH; Li J; Ni YB; Shao Y; Chan SK; Cheungc SY; Lau KF; Tse GMK
    EBioMedicine; 2018 Dec; 38():89-99. PubMed ID: 30470613
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein.
    Harris B; Pereira I; Parkin E
    Brain Res; 2009 Nov; 1296():203-15. PubMed ID: 19679113
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Melatonin regulates the transcription of βAPP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells.
    Panmanee J; Nopparat C; Chavanich N; Shukla M; Mukda S; Song W; Vincent B; Govitrapong P
    J Pineal Res; 2015 Oct; 59(3):308-20. PubMed ID: 26123100
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A disintegrin and metalloprotease 10 activity sheds the ectodomain of the amyloid precursor-like protein 2 and regulates protein expression in proximal tubule cells.
    Cong R; Li Y; Biemesderfer D
    Am J Physiol Cell Physiol; 2011 Jun; 300(6):C1366-74. PubMed ID: 21325636
    [TBL] [Abstract][Full Text] [Related]  

  • 16. β-site amyloid precursor protein cleaving enzyme 1(BACE1) regulates Notch signaling by controlling the cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) proteins.
    He W; Hu J; Xia Y; Yan R
    J Biol Chem; 2014 Jul; 289(30):20630-7. PubMed ID: 24907271
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP.
    Corbett GT; Gonzalez FJ; Pahan K
    Proc Natl Acad Sci U S A; 2015 Jul; 112(27):8445-50. PubMed ID: 26080426
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Alpha-secretase cleavage of the amyloid precursor protein: proteolysis regulated by signaling pathways and protein trafficking.
    Lichtenthaler SF
    Curr Alzheimer Res; 2012 Feb; 9(2):165-77. PubMed ID: 21605033
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.
    Hata S; Fujishige S; Araki Y; Kato N; Araseki M; Nishimura M; Hartmann D; Saftig P; Fahrenholz F; Taniguchi M; Urakami K; Akatsu H; Martins RN; Yamamoto K; Maeda M; Yamamoto T; Nakaya T; Gandy S; Suzuki T
    J Biol Chem; 2009 Dec; 284(52):36024-36033. PubMed ID: 19864413
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Dual role of alpha-secretase cleavage in the regulation of gamma-secretase activity for amyloid production.
    Tian Y; Crump CJ; Li YM
    J Biol Chem; 2010 Oct; 285(42):32549-56. PubMed ID: 20675367
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 26.