These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

184 related articles for article (PubMed ID: 21704184)

  • 1. Getting physical in drug discovery II: the impact of chromatographic hydrophobicity measurements and aromaticity.
    Young RJ; Green DV; Luscombe CN; Hill AP
    Drug Discov Today; 2011 Sep; 16(17-18):822-30. PubMed ID: 21704184
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Getting physical in drug discovery: a contemporary perspective on solubility and hydrophobicity.
    Hill AP; Young RJ
    Drug Discov Today; 2010 Aug; 15(15-16):648-55. PubMed ID: 20570751
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The impact of aromatic ring count on compound developability: further insights by examining carbo- and hetero-aromatic and -aliphatic ring types.
    Ritchie TJ; Macdonald SJ; Young RJ; Pickett SD
    Drug Discov Today; 2011 Feb; 16(3-4):164-71. PubMed ID: 21129497
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Determination of the hydrophobicity of organic compounds measured as logP(o/w) through a new chromatographic method.
    Pallicer JM; Pous-Torres S; Sales J; Rosés M; Ràfols C; Bosch E
    J Chromatogr A; 2010 Apr; 1217(18):3026-37. PubMed ID: 20338568
    [TBL] [Abstract][Full Text] [Related]  

  • 5. ADME evaluation in drug discovery. 2. Prediction of partition coefficient by atom-additive approach based on atom-weighted solvent accessible surface areas.
    Hou TJ; Xu XJ
    J Chem Inf Comput Sci; 2003; 43(3):1058-67. PubMed ID: 12767165
    [TBL] [Abstract][Full Text] [Related]  

  • 6. High-throughput logPo/w determination from UHPLC measurements: Revisiting the chromatographic hydrophobicity index.
    Subirats X; Rosés M; Bosch E
    J Pharm Biomed Anal; 2016 Aug; 127():26-31. PubMed ID: 26732880
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Lipophilicity of basic drugs measured by hydrophilic interaction chromatography.
    Bard B; Carrupt PA; Martel S
    J Med Chem; 2009 May; 52(10):3416-9. PubMed ID: 19397318
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The impact of aromatic ring count on compound developability--are too many aromatic rings a liability in drug design?
    Ritchie TJ; Macdonald SJ
    Drug Discov Today; 2009 Nov; 14(21-22):1011-20. PubMed ID: 19729075
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Physicochemical descriptors of aromatic character and their use in drug discovery.
    Ritchie TJ; Macdonald SJ
    J Med Chem; 2014 Sep; 57(17):7206-15. PubMed ID: 24856517
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pharmacological promiscuity: dependence on compound properties and target specificity in a set of recent Roche compounds.
    Peters JU; Schnider P; Mattei P; Kansy M
    ChemMedChem; 2009 Apr; 4(4):680-6. PubMed ID: 19266525
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Modelling, solubility and pK(a) of five sparingly soluble drugs.
    Domańska U; Pobudkowska A; Pelczarska A; Zukowski L
    Int J Pharm; 2011 Jan; 403(1-2):115-22. PubMed ID: 21034801
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Quest for the rings. In silico exploration of ring universe to identify novel bioactive heteroaromatic scaffolds.
    Ertl P; Jelfs S; Mühlbacher J; Schuffenhauer A; Selzer P
    J Med Chem; 2006 Jul; 49(15):4568-73. PubMed ID: 16854061
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The performance of 1-ethyl-3-methylimidazolium tetrafluoroborate ionic liquid as mobile phase additive in HPLC-based lipophilicity assessment.
    Giaginis C; Tsantili-Kakoulidou A
    Biomed Chromatogr; 2011 May; 25(5):606-12. PubMed ID: 20740480
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A comparison of theoretical methods of calculation of partition coefficients for selected drugs.
    Pyka A; Babuśka M; Zachariasz M
    Acta Pol Pharm; 2006; 63(3):159-67. PubMed ID: 20085219
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Large, chemically diverse dataset of logP measurements for benchmarking studies.
    Martel S; Gillerat F; Carosati E; Maiarelli D; Tetko IV; Mannhold R; Carrupt PA
    Eur J Pharm Sci; 2013 Jan; 48(1-2):21-9. PubMed ID: 23131797
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery.
    Wasan KM; Brocks DR; Lee SD; Sachs-Barrable K; Thornton SJ
    Nat Rev Drug Discov; 2008 Jan; 7(1):84-99. PubMed ID: 18079757
    [TBL] [Abstract][Full Text] [Related]  

  • 17. [Practical aspects of partition measurements according to GLP rules].
    Takácsné Novák K
    Acta Pharm Hung; 1997 Sep; 67(5):179-91. PubMed ID: 9432865
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Hydrophobicity of ionisable compounds studied by countercurrent chromatography.
    Ruiz-Ángel MJ; Carda-Broch S; Levet A; Berthod A
    J Chromatogr A; 2011 Sep; 1218(36):6044-52. PubMed ID: 21269630
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Analysis of polar metabolites by hydrophilic interaction chromatography--MS/MS.
    Jian W; Xu Y; Edom RW; Weng N
    Bioanalysis; 2011 Apr; 3(8):899-912. PubMed ID: 21510763
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Lipophilicity assessment of basic drugs (log P(o/w) determination) by a chromatographic method.
    Pallicer JM; Sales J; Rosés M; Ràfols C; Bosch E
    J Chromatogr A; 2011 Sep; 1218(37):6356-68. PubMed ID: 21820118
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.