These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
2. Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice. Pankiewicz JE; Guridi M; Kim J; Asuni AA; Sanchez S; Sullivan PM; Holtzman DM; Sadowski MJ Acta Neuropathol Commun; 2014 Jun; 2():75. PubMed ID: 24972680 [TBL] [Abstract][Full Text] [Related]
3. Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide. Hashimoto T; Serrano-Pozo A; Hori Y; Adams KW; Takeda S; Banerji AO; Mitani A; Joyner D; Thyssen DH; Bacskai BJ; Frosch MP; Spires-Jones TL; Finn MB; Holtzman DM; Hyman BT J Neurosci; 2012 Oct; 32(43):15181-92. PubMed ID: 23100439 [TBL] [Abstract][Full Text] [Related]
4. Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice. Bales KR; Liu F; Wu S; Lin S; Koger D; DeLong C; Hansen JC; Sullivan PM; Paul SM J Neurosci; 2009 May; 29(21):6771-9. PubMed ID: 19474305 [TBL] [Abstract][Full Text] [Related]
5. Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples. Tai LM; Bilousova T; Jungbauer L; Roeske SK; Youmans KL; Yu C; Poon WW; Cornwell LB; Miller CA; Vinters HV; Van Eldik LJ; Fardo DW; Estus S; Bu G; Gylys KH; Ladu MJ J Biol Chem; 2013 Feb; 288(8):5914-26. PubMed ID: 23293020 [TBL] [Abstract][Full Text] [Related]
6. APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease. Youmans KL; Tai LM; Nwabuisi-Heath E; Jungbauer L; Kanekiyo T; Gan M; Kim J; Eimer WA; Estus S; Rebeck GW; Weeber EJ; Bu G; Yu C; Ladu MJ J Biol Chem; 2012 Dec; 287(50):41774-86. PubMed ID: 23060451 [TBL] [Abstract][Full Text] [Related]
7. Apolipoprotein E isoform-dependent effects on the processing of Alzheimer's amyloid-β. Chai AB; Lam HHJ; Kockx M; Gelissen IC Biochim Biophys Acta Mol Cell Biol Lipids; 2021 Sep; 1866(9):158980. PubMed ID: 34044125 [TBL] [Abstract][Full Text] [Related]
8. Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease. Wahrle SE; Jiang H; Parsadanian M; Hartman RE; Bales KR; Paul SM; Holtzman DM J Biol Chem; 2005 Dec; 280(52):43236-42. PubMed ID: 16207708 [TBL] [Abstract][Full Text] [Related]
9. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. Deane R; Sagare A; Hamm K; Parisi M; Lane S; Finn MB; Holtzman DM; Zlokovic BV J Clin Invest; 2008 Dec; 118(12):4002-13. PubMed ID: 19033669 [TBL] [Abstract][Full Text] [Related]
10. Apolipoprotein E genotype and the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer disease. Lautner R; Palmqvist S; Mattsson N; Andreasson U; Wallin A; Pålsson E; Jakobsson J; Herukka SK; Owenius R; Olsson B; Hampel H; Rujescu D; Ewers M; Landén M; Minthon L; Blennow K; Zetterberg H; Hansson O; JAMA Psychiatry; 2014 Oct; 71(10):1183-91. PubMed ID: 25162367 [TBL] [Abstract][Full Text] [Related]
11. Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice. Fitz NF; Cronican AA; Saleem M; Fauq AH; Chapman R; Lefterov I; Koldamova R J Neurosci; 2012 Sep; 32(38):13125-36. PubMed ID: 22993429 [TBL] [Abstract][Full Text] [Related]
12. Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. Fryer JD; Simmons K; Parsadanian M; Bales KR; Paul SM; Sullivan PM; Holtzman DM J Neurosci; 2005 Mar; 25(11):2803-10. PubMed ID: 15772340 [TBL] [Abstract][Full Text] [Related]
13. Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation. Buttini M; Yu GQ; Shockley K; Huang Y; Jones B; Masliah E; Mallory M; Yeo T; Longo FM; Mucke L J Neurosci; 2002 Dec; 22(24):10539-48. PubMed ID: 12486146 [TBL] [Abstract][Full Text] [Related]
14. Macrophage-mediated degradation of beta-amyloid via an apolipoprotein E isoform-dependent mechanism. Zhao L; Lin S; Bales KR; Gelfanova V; Koger D; Delong C; Hale J; Liu F; Hunter JM; Paul SM J Neurosci; 2009 Mar; 29(11):3603-12. PubMed ID: 19295164 [TBL] [Abstract][Full Text] [Related]
15. Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition. Rodriguez GA; Tai LM; LaDu MJ; Rebeck GW J Neuroinflammation; 2014 Jun; 11():111. PubMed ID: 24948358 [TBL] [Abstract][Full Text] [Related]
17. Profiles of β-Amyloid Peptides and Key Secretases in Brain Autopsy Samples Differ with Sex and APOE ε4 Status: Impact for Risk and Progression of Alzheimer Disease. Nyarko JNK; Quartey MO; Pennington PR; Heistad RM; Dea D; Poirier J; Baker GB; Mousseau DD Neuroscience; 2018 Mar; 373():20-36. PubMed ID: 29331531 [TBL] [Abstract][Full Text] [Related]
18. Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis. Mahan TE; Wang C; Bao X; Choudhury A; Ulrich JD; Holtzman DM Mol Neurodegener; 2022 Feb; 17(1):13. PubMed ID: 35109920 [TBL] [Abstract][Full Text] [Related]
19. Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice. Hu J; Liu CC; Chen XF; Zhang YW; Xu H; Bu G Mol Neurodegener; 2015 Mar; 10():6. PubMed ID: 25871773 [TBL] [Abstract][Full Text] [Related]
20. A flow cytometry-based Kara E; Marks JD; Roe AD; Commins C; Fan Z; Calvo-Rodriguez M; Wegmann S; Hudry E; Hyman BT J Biol Chem; 2018 Aug; 293(34):13247-13256. PubMed ID: 29950521 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]