BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

131 related articles for article (PubMed ID: 21721554)

  • 1. Fluorescence probe for lysophospholipase C/NPP6 activity and a potent NPP6 inhibitor.
    Kawaguchi M; Okabe T; Okudaira S; Hanaoka K; Fujikawa Y; Terai T; Komatsu T; Kojima H; Aoki J; Nagano T
    J Am Chem Soc; 2011 Aug; 133(31):12021-30. PubMed ID: 21721554
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family.
    Sakagami H; Aoki J; Natori Y; Nishikawa K; Kakehi Y; Natori Y; Arai H
    J Biol Chem; 2005 Jun; 280(24):23084-93. PubMed ID: 15788404
    [TBL] [Abstract][Full Text] [Related]  

  • 3. N-Glycomic and Microscopic Subcellular Localization Analyses of NPP1, 2 and 6 Strongly Indicate that trans-Golgi Compartments Participate in the Golgi to Plastid Traffic of Nucleotide Pyrophosphatase/Phosphodiesterases in Rice.
    Kaneko K; Takamatsu T; Inomata T; Oikawa K; Itoh K; Hirose K; Amano M; Nishimura S; Toyooka K; Matsuoka K; Pozueta-Romero J; Mitsui T
    Plant Cell Physiol; 2016 Aug; 57(8):1610-28. PubMed ID: 27335351
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe.
    Kawaguchi M; Okabe T; Okudaira S; Nishimasu H; Ishitani R; Kojima H; Nureki O; Aoki J; Nagano T
    ACS Chem Biol; 2013 Aug; 8(8):1713-21. PubMed ID: 23688339
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Nucleotide pyrophosphatase/phosphodiesterase 1 exerts a negative effect on starch accumulation and growth in rice seedlings under high temperature and CO2 concentration conditions.
    Kaneko K; Inomata T; Masui T; Koshu T; Umezawa Y; Itoh K; Pozueta-Romero J; Mitsui T
    Plant Cell Physiol; 2014 Feb; 55(2):320-32. PubMed ID: 24092883
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Diadenosine 5',5''-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors.
    Eliahu S; Lecka J; Reiser G; Haas M; Bigonnesse F; Lévesque SA; Pelletier J; Sévigny J; Fischer B
    J Med Chem; 2010 Dec; 53(24):8485-97. PubMed ID: 21090681
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Development of an activity-based probe for autotaxin.
    Cavalli S; Houben AJ; Albers HM; van Tilburg EW; de Ru A; Aoki J; van Veelen P; Moolenaar WH; Ovaa H
    Chembiochem; 2010 Nov; 11(16):2311-7. PubMed ID: 20941725
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Functional characterization of the non-catalytic ectodomains of the nucleotide pyrophosphatase/phosphodiesterase NPP1.
    Gijsbers R; Ceulemans H; Bollen M
    Biochem J; 2003 Apr; 371(Pt 2):321-30. PubMed ID: 12533192
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Nonhydrolyzable ATP analogues as selective inhibitors of human NPP1: a combined computational/experimental study.
    Lecka J; Ben-David G; Simhaev L; Eliahu S; Oscar J; Luyindula P; Pelletier J; Fischer B; Senderowitz H; Sévigny J
    J Med Chem; 2013 Nov; 56(21):8308-20. PubMed ID: 24083941
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Evaluation of sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as inhibitors of nucleotide pyrophosphatases/phosphodiesterases and anticancer agents.
    Anbar HS; El-Gamal R; Ullah S; Zaraei SO; Al-Rashida M; Zaib S; Pelletier J; Sévigny J; Iqbal J; El-Gamal MI
    Bioorg Chem; 2020 Nov; 104():104305. PubMed ID: 33017718
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Proteolytic maturation and activation of autotaxin (NPP2), a secreted metastasis-enhancing lysophospholipase D.
    Jansen S; Stefan C; Creemers JW; Waelkens E; Van Eynde A; Stalmans W; Bollen M
    J Cell Sci; 2005 Jul; 118(Pt 14):3081-9. PubMed ID: 15985467
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.
    Fells JI; Lee SC; Fujiwara Y; Norman DD; Lim KG; Tsukahara R; Liu J; Patil R; Miller DD; Kirby RJ; Nelson S; Seibel W; Papoian R; Parrill AL; Baker DL; Bittman R; Tigyi G
    Mol Pharmacol; 2013 Sep; 84(3):415-24. PubMed ID: 23793291
    [TBL] [Abstract][Full Text] [Related]  

  • 13. NPP-type ectophosphodiesterases: unity in diversity.
    Stefan C; Jansen S; Bollen M
    Trends Biochem Sci; 2005 Oct; 30(10):542-50. PubMed ID: 16125936
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and biological evaluation of novel quinazoline-4-piperidinesulfamide derivatives as inhibitors of NPP1.
    Forcellini E; Boutin S; Lefebvre CA; Shayhidin EE; Boulanger MC; Rhéaume G; Barbeau X; Lagüe P; Mathieu P; Paquin JF
    Eur J Med Chem; 2018 Mar; 147():130-149. PubMed ID: 29427906
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia.
    Ho GD; Yang SW; Smotryski J; Bercovici A; Nechuta T; Smith EM; McElroy W; Tan Z; Tulshian D; McKittrick B; Greenlee WJ; Hruza A; Xiao L; Rindgen D; Mullins D; Guzzi M; Zhang X; Bleickardt C; Hodgson R
    Bioorg Med Chem Lett; 2012 Jan; 22(2):1019-22. PubMed ID: 22222034
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Substrate-specifying determinants of the nucleotide pyrophosphatases/phosphodiesterases NPP1 and NPP2.
    Cimpean A; Stefan C; Gijsbers R; Stalmans W; Bollen M
    Biochem J; 2004 Jul; 381(Pt 1):71-7. PubMed ID: 15096095
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Polyoxometalates--potent and selective ecto-nucleotidase inhibitors.
    Lee SY; Fiene A; Li W; Hanck T; Brylev KA; Fedorov VE; Lecka J; Haider A; Pietzsch HJ; Zimmermann H; Sévigny J; Kortz U; Stephan H; Müller CE
    Biochem Pharmacol; 2015 Jan; 93(2):171-81. PubMed ID: 25449596
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Site-directed mutations in the tumor-associated cytokine, autotaxin, eliminate nucleotide phosphodiesterase, lysophospholipase D, and motogenic activities.
    Koh E; Clair T; Woodhouse EC; Schiffmann E; Liotta L; Stracke M
    Cancer Res; 2003 May; 63(9):2042-5. PubMed ID: 12727817
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Highly Selective and Potent Ectonucleotide Pyrophosphatase-1 (NPP1) Inhibitors Based on Uridine 5'-P
    Zelikman V; Pelletier J; Simhaev L; Sela A; Gendron FP; Arguin G; Senderowitz H; Sévigny J; Fischer B
    J Med Chem; 2018 May; 61(9):3939-3951. PubMed ID: 29681152
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Imidazopyridine- and purine-thioacetamide derivatives: potent inhibitors of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1).
    Chang L; Lee SY; Leonczak P; Rozenski J; De Jonghe S; Hanck T; Müller CE; Herdewijn P
    J Med Chem; 2014 Dec; 57(23):10080-100. PubMed ID: 25372276
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.