BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

599 related articles for article (PubMed ID: 21723501)

  • 1. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways.
    Yecies JL; Zhang HH; Menon S; Liu S; Yecies D; Lipovsky AI; Gorgun C; Kwiatkowski DJ; Hotamisligil GS; Lee CH; Manning BD
    Cell Metab; 2011 Jul; 14(1):21-32. PubMed ID: 21723501
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Livers with constitutive mTORC1 activity resist steatosis independent of feedback suppression of Akt.
    Kenerson HL; Subramanian S; McIntyre R; Kazami M; Yeung RS
    PLoS One; 2015; 10(2):e0117000. PubMed ID: 25646773
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c.
    Wan M; Leavens KF; Saleh D; Easton RM; Guertin DA; Peterson TR; Kaestner KH; Sabatini DM; Birnbaum MJ
    Cell Metab; 2011 Oct; 14(4):516-27. PubMed ID: 21982711
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation.
    Kenerson HL; Yeh MM; Yeung RS
    PLoS One; 2011 Mar; 6(3):e18075. PubMed ID: 21479224
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.
    Hagiwara A; Cornu M; Cybulski N; Polak P; Betz C; Trapani F; Terracciano L; Heim MH; Rüegg MA; Hall MN
    Cell Metab; 2012 May; 15(5):725-38. PubMed ID: 22521878
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Hepatic mTOR-AKT2-Insig2 signaling pathway contributes to the improvement of hepatic steatosis after Roux-en-Y Gastric Bypass in mice.
    Pan Q; Qin T; Gao Y; Li S; Li D; Peng M; Zhai H; Xu G
    Biochim Biophys Acta Mol Basis Dis; 2019 Mar; 1865(3):525-534. PubMed ID: 30562559
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase.
    Copps KD; Hançer NJ; Qiu W; White MF
    J Biol Chem; 2016 Apr; 291(16):8602-17. PubMed ID: 26846849
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma.
    Calvisi DF; Wang C; Ho C; Ladu S; Lee SA; Mattu S; Destefanis G; Delogu S; Zimmermann A; Ericsson J; Brozzetti S; Staniscia T; Chen X; Dombrowski F; Evert M
    Gastroenterology; 2011 Mar; 140(3):1071-83. PubMed ID: 21147110
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2.
    Yuan M; Pino E; Wu L; Kacergis M; Soukas AA
    J Biol Chem; 2012 Aug; 287(35):29579-88. PubMed ID: 22773877
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability.
    Pajvani UB; Qiang L; Kangsamaksin T; Kitajewski J; Ginsberg HN; Accili D
    Nat Med; 2013 Aug; 19(8):1054-60. PubMed ID: 23832089
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Connecting mTORC1 signaling to SREBP-1 activation.
    Bakan I; Laplante M
    Curr Opin Lipidol; 2012 Jun; 23(3):226-234. PubMed ID: 22449814
    [TBL] [Abstract][Full Text] [Related]  

  • 12. DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease.
    Chen H; Shen F; Sherban A; Nocon A; Li Y; Wang H; Xu MJ; Rui X; Han J; Jiang B; Lee D; Li N; Keyhani-Nejad F; Fan JG; Liu F; Kamat A; Musi N; Guarente L; Pacher P; Gao B; Zang M
    Hepatology; 2018 Aug; 68(2):496-514. PubMed ID: 29457836
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.
    Zhang HH; Huang J; Düvel K; Boback B; Wu S; Squillace RM; Wu CL; Manning BD
    PLoS One; 2009 Jul; 4(7):e6189. PubMed ID: 19593385
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production.
    Titchenell PM; Quinn WJ; Lu M; Chu Q; Lu W; Li C; Chen H; Monks BR; Chen J; Rabinowitz JD; Birnbaum MJ
    Cell Metab; 2016 Jun; 23(6):1154-1166. PubMed ID: 27238637
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia.
    Wolff NC; Vega-Rubin-de-Celis S; Xie XJ; Castrillon DH; Kabbani W; Brugarolas J
    Mol Cell Biol; 2011 May; 31(9):1870-84. PubMed ID: 21383064
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.
    Menon S; Yecies JL; Zhang HH; Howell JJ; Nicholatos J; Harputlugil E; Bronson RT; Kwiatkowski DJ; Manning BD
    Sci Signal; 2012 Mar; 5(217):ra24. PubMed ID: 22457330
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis.
    Li S; Brown MS; Goldstein JL
    Proc Natl Acad Sci U S A; 2010 Feb; 107(8):3441-6. PubMed ID: 20133650
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Role of S6K1 in regulation of SREBP1c expression in the liver.
    Li S; Ogawa W; Emi A; Hayashi K; Senga Y; Nomura K; Hara K; Yu D; Kasuga M
    Biochem Biophys Res Commun; 2011 Aug; 412(2):197-202. PubMed ID: 21806970
    [TBL] [Abstract][Full Text] [Related]  

  • 19. ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signaling.
    Winter JN; Jefferson LS; Kimball SR
    Am J Physiol Cell Physiol; 2011 May; 300(5):C1172-80. PubMed ID: 21289294
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Hyperactivation of mammalian target of rapamycin complex 1 (mTORC1) promotes breast cancer progression through enhancing glucose starvation-induced autophagy and Akt signaling.
    Chen Y; Wei H; Liu F; Guan JL
    J Biol Chem; 2014 Jan; 289(2):1164-73. PubMed ID: 24275666
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 30.