183 related articles for article (PubMed ID: 21723875)
1. Enzyme inhibition by allosteric capture of an inactive conformation.
Lee GM; Shahian T; Baharuddin A; Gable JE; Craik CS
J Mol Biol; 2011 Sep; 411(5):999-1016. PubMed ID: 21723875
[TBL] [Abstract][Full Text] [Related]
2. Conformational change coupling the dimerization and activation of KSHV protease.
Pray TR; Reiling KK; Demirjian BG; Craik CS
Biochemistry; 2002 Feb; 41(5):1474-82. PubMed ID: 11814340
[TBL] [Abstract][Full Text] [Related]
3. Broad-spectrum allosteric inhibition of herpesvirus proteases.
Gable JE; Lee GM; Jaishankar P; Hearn BR; Waddling CA; Renslo AR; Craik CS
Biochemistry; 2014 Jul; 53(28):4648-60. PubMed ID: 24977643
[TBL] [Abstract][Full Text] [Related]
4. Functional consequences of the Kaposi's sarcoma-associated herpesvirus protease structure: regulation of activity and dimerization by conserved structural elements.
Reiling KK; Pray TR; Craik CS; Stroud RM
Biochemistry; 2000 Oct; 39(42):12796-803. PubMed ID: 11041844
[TBL] [Abstract][Full Text] [Related]
5. Auto-inactivation by cleavage within the dimer interface of Kaposi's sarcoma-associated herpesvirus protease.
Pray TR; Nomura AM; Pennington MW; Craik CS
J Mol Biol; 1999 Jun; 289(2):197-203. PubMed ID: 10366498
[TBL] [Abstract][Full Text] [Related]
6. Herpesvirus protease inhibition by dimer disruption.
Shimba N; Nomura AM; Marnett AB; Craik CS
J Virol; 2004 Jun; 78(12):6657-65. PubMed ID: 15163756
[TBL] [Abstract][Full Text] [Related]
7. The protease and the assembly protein of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8).
Unal A; Pray TR; Lagunoff M; Pennington MW; Ganem D; Craik CS
J Virol; 1997 Sep; 71(9):7030-8. PubMed ID: 9261433
[TBL] [Abstract][Full Text] [Related]
8. Induced structure of a helical switch as a mechanism to regulate enzymatic activity.
Nomura AM; Marnett AB; Shimba N; Dötsch V; Craik CS
Nat Struct Mol Biol; 2005 Nov; 12(11):1019-20. PubMed ID: 16244665
[TBL] [Abstract][Full Text] [Related]
9. One functional switch mediates reversible and irreversible inactivation of a herpesvirus protease.
Nomura AM; Marnett AB; Shimba N; Dötsch V; Craik CS
Biochemistry; 2006 Mar; 45(11):3572-9. PubMed ID: 16533039
[TBL] [Abstract][Full Text] [Related]
10. Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric Protease.
Gable JE; Lee GM; Acker TM; Hulce KR; Gonzalez ER; Schweigler P; Melkko S; Farady CJ; Craik CS
ChemMedChem; 2016 Apr; 11(8):862-9. PubMed ID: 26822284
[TBL] [Abstract][Full Text] [Related]
11. Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases.
Acker TM; Gable JE; Bohn MF; Jaishankar P; Thompson MC; Fraser JS; Renslo AR; Craik CS
J Am Chem Soc; 2017 Aug; 139(34):11650-11653. PubMed ID: 28759216
[TBL] [Abstract][Full Text] [Related]
12. Molecular mechanism for dimerization to regulate the catalytic activity of human cytomegalovirus protease.
Batra R; Khayat R; Tong L
Nat Struct Biol; 2001 Sep; 8(9):810-7. PubMed ID: 11524687
[TBL] [Abstract][Full Text] [Related]
13. Inhibition of a viral enzyme by a small-molecule dimer disruptor.
Shahian T; Lee GM; Lazic A; Arnold LA; Velusamy P; Roels CM; Guy RK; Craik CS
Nat Chem Biol; 2009 Sep; 5(9):640-6. PubMed ID: 19633659
[TBL] [Abstract][Full Text] [Related]
14. A screening strategy for trapping the inactive conformer of a dimeric enzyme with a small molecule inhibitor.
Craik CS; Shahian T
Methods Mol Biol; 2012; 928():119-31. PubMed ID: 22956137
[TBL] [Abstract][Full Text] [Related]
15. The effect of dimerization and ligand binding on the dynamics of Kaposi's sarcoma-associated herpesvirus protease.
Bern D; Tobi D
Proteins; 2022 Jun; 90(6):1267-1277. PubMed ID: 35084062
[TBL] [Abstract][Full Text] [Related]
16. The crystal structure of the Epstein-Barr virus protease shows rearrangement of the processed C terminus.
Buisson M; Hernandez JF; Lascoux D; Schoehn G; Forest E; Arlaud G; Seigneurin JM; Ruigrok RW; Burmeister WP
J Mol Biol; 2002 Nov; 324(1):89-103. PubMed ID: 12421561
[TBL] [Abstract][Full Text] [Related]
17. Activity in monomers of human cytomegalovirus protease.
Holwerda B
Biochem Biophys Res Commun; 1999 Jun; 259(2):370-3. PubMed ID: 10362516
[TBL] [Abstract][Full Text] [Related]
18. Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor.
Marnett AB; Nomura AM; Shimba N; Ortiz de Montellano PR; Craik CS
Proc Natl Acad Sci U S A; 2004 May; 101(18):6870-5. PubMed ID: 15118083
[TBL] [Abstract][Full Text] [Related]
19. Structural and biochemical studies of inhibitor binding to human cytomegalovirus protease.
Khayat R; Batra R; Qian C; Halmos T; Bailey M; Tong L
Biochemistry; 2003 Feb; 42(4):885-91. PubMed ID: 12549906
[TBL] [Abstract][Full Text] [Related]
20. Investigating the role of histidine 157 in the catalytic activity of human cytomegalovirus protease.
Khayat R; Batra R; Massariol MJ; Lagacé L; Tong L
Biochemistry; 2001 May; 40(21):6344-51. PubMed ID: 11371196
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
