These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
156 related articles for article (PubMed ID: 21726415)
21. Selective inhibitors of Candida albicans dihydrofolate reductase: activity and selectivity of 5-(arylthio)-2,4-diaminoquinazolines. Chan JH; Hong JS; Kuyper LF; Baccanari DP; Joyner SS; Tansik RL; Boytos CM; Rudolph SK J Med Chem; 1995 Sep; 38(18):3608-16. PubMed ID: 7658448 [TBL] [Abstract][Full Text] [Related]
22. Structural analysis of a holoenzyme complex of mouse dihydrofolate reductase with NADPH and a ternary complex with the potent and selective inhibitor 2,4-diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine. Cody V; Pace J; Rosowsky A Acta Crystallogr D Biol Crystallogr; 2008 Sep; 64(Pt 9):977-84. PubMed ID: 18703847 [TBL] [Abstract][Full Text] [Related]
23. Protein flexibility and species specificity in structure-based drug discovery: dihydrofolate reductase as a test system. Bowman AL; Lerner MG; Carlson HA J Am Chem Soc; 2007 Mar; 129(12):3634-40. PubMed ID: 17335207 [TBL] [Abstract][Full Text] [Related]
24. Structural analysis of human dihydrofolate reductase as a binary complex with the potent and selective inhibitor 2,4-diamino-6-{2'-O-(3-carboxypropyl)oxydibenz[b,f]-azepin-5-yl}methylpteridine reveals an unusual binding mode. Cody V; Pace J; Nowak J Acta Crystallogr D Biol Crystallogr; 2011 Oct; 67(Pt 10):875-80. PubMed ID: 21931219 [TBL] [Abstract][Full Text] [Related]
25. Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate. Senkovich O; Schormann N; Chattopadhyay D Acta Crystallogr D Biol Crystallogr; 2009 Jul; 65(Pt 7):704-16. PubMed ID: 19564691 [TBL] [Abstract][Full Text] [Related]
26. Scoring ensembles of docked protein:ligand interactions for virtual lead optimization. Paulsen JL; Anderson AC J Chem Inf Model; 2009 Dec; 49(12):2813-9. PubMed ID: 19950979 [TBL] [Abstract][Full Text] [Related]
27. Towards new antifolates targeting eukaryotic opportunistic infections. Liu J; Bolstad DB; Bolstad ES; Wright DL; Anderson AC Eukaryot Cell; 2009 Apr; 8(4):483-6. PubMed ID: 19168759 [TBL] [Abstract][Full Text] [Related]
28. Insights into the selective inhibition of Candida albicans secreted aspartyl protease: a docking analysis study. Pranav Kumar SK; Kulkarni VM Bioorg Med Chem; 2002 Apr; 10(4):1153-70. PubMed ID: 11836127 [TBL] [Abstract][Full Text] [Related]
29. Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus. Keshipeddy S; Reeve SM; Anderson AC; Wright DL J Am Chem Soc; 2015 Jul; 137(28):8983-90. PubMed ID: 26098608 [TBL] [Abstract][Full Text] [Related]
30. Structure-based enzyme inhibitor design: modeling studies and crystal structure analysis of Pneumocystis carinii dihydrofolate reductase ternary complex with PT653 and NADPH. Cody V; Galitsky N; Luft JR; Pangborn W; Rosowsky A; Queener SF Acta Crystallogr D Biol Crystallogr; 2002 Jun; 58(Pt 6 Pt 2):946-54. PubMed ID: 12037296 [TBL] [Abstract][Full Text] [Related]
31. A molecular model of the folate binding site of Pneumocystis carinii dihydrofolate reductase. Southerland WM J Comput Aided Mol Des; 1994 Apr; 8(2):113-22. PubMed ID: 8064329 [TBL] [Abstract][Full Text] [Related]
32. Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates. Lombardo MN; G-Dayanandan N; Wright DL; Anderson AC ACS Infect Dis; 2016 Feb; 2(2):149-56. PubMed ID: 27624966 [TBL] [Abstract][Full Text] [Related]
33. New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions. Cody V; Pace J; Chisum K; Rosowsky A Proteins; 2006 Dec; 65(4):959-69. PubMed ID: 17019704 [TBL] [Abstract][Full Text] [Related]
34. Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase. Cody V; Luft JR; Pangborn W; Gangjee A Acta Crystallogr D Biol Crystallogr; 2003 Sep; 59(Pt 9):1603-9. PubMed ID: 12925791 [TBL] [Abstract][Full Text] [Related]
35. Novel heterocyclic hybrids of pyrazole targeting dihydrofolate reductase: design, biological evaluation and Othman IMM; Gad-Elkareem MAM; Amr AEE; Al-Omar MA; Nossier ES; Elsayed EA J Enzyme Inhib Med Chem; 2020 Dec; 35(1):1491-1502. PubMed ID: 32668994 [TBL] [Abstract][Full Text] [Related]
36. Crystal structure of dihydrofolate reductase from the emerging pathogenic fungus Candida auris. Kirkman T; Sketcher A; de Morais Barroso V; Ishida K; Tosin M; Dias MVB Acta Crystallogr D Struct Biol; 2023 Aug; 79(Pt 8):735-745. PubMed ID: 37428844 [TBL] [Abstract][Full Text] [Related]
37. Two crystal structures of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveal protein-ligand interactions including a structural basis for observed antifolate resistance. Anderson AC Acta Crystallogr Sect F Struct Biol Cryst Commun; 2005 Mar; 61(Pt 3):258-62. PubMed ID: 16511011 [TBL] [Abstract][Full Text] [Related]
38. Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents. Shah K; Lin X; Queener SF; Cody V; Pace J; Gangjee A Bioorg Med Chem; 2018 May; 26(9):2640-2650. PubMed ID: 29691153 [TBL] [Abstract][Full Text] [Related]
39. The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase. Duff MR; Gabel SA; Pedersen LC; DeRose EF; Krahn JM; Howell EE; London RE J Med Chem; 2020 Aug; 63(15):8314-8324. PubMed ID: 32658475 [TBL] [Abstract][Full Text] [Related]
40. Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 a and 1.05 a resolution. Klon AE; Héroux A; Ross LJ; Pathak V; Johnson CA; Piper JR; Borhani DW J Mol Biol; 2002 Jul; 320(3):677-93. PubMed ID: 12096917 [TBL] [Abstract][Full Text] [Related] [Previous] [Next] [New Search]