These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

202 related articles for article (PubMed ID: 21728742)

  • 1. Flavopiridol induces BCL-2 expression and represses oncogenic transcription factors in leukemic blasts from adults with refractory acute myeloid leukemia.
    Nelson DM; Joseph B; Hillion J; Segal J; Karp JE; Resar LM
    Leuk Lymphoma; 2011 Oct; 52(10):1999-2006. PubMed ID: 21728742
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions.
    Rosato RR; Almenara JA; Kolla SS; Maggio SC; Coe S; Giménez MS; Dent P; Grant S
    Mol Cancer Ther; 2007 Feb; 6(2):692-702. PubMed ID: 17308065
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy.
    Lee YK; Isham CR; Kaufman SH; Bible KC
    Mol Cancer Ther; 2006 Jan; 5(1):138-48. PubMed ID: 16432172
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Timed sequential therapy of acute leukemia with flavopiridol: in vitro model for a phase I clinical trial.
    Karp JE; Ross DD; Yang W; Tidwell ML; Wei Y; Greer J; Mann DL; Nakanishi T; Wright JJ; Colevas AD
    Clin Cancer Res; 2003 Jan; 9(1):307-15. PubMed ID: 12538483
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-kappaB-dependent process.
    Dai Y; Rahmani M; Grant S
    Oncogene; 2003 Oct; 22(46):7108-22. PubMed ID: 14562039
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53.
    Byrd JC; Shinn C; Waselenko JK; Fuchs EJ; Lehman TA; Nguyen PL; Flinn IW; Diehl LF; Sausville E; Grever MR
    Blood; 1998 Nov; 92(10):3804-16. PubMed ID: 9808574
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Clinical activity of alvocidib (flavopiridol) in acute myeloid leukemia.
    Zeidner JF; Karp JE
    Leuk Res; 2015 Dec; 39(12):1312-8. PubMed ID: 26521988
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Sequential flavopiridol, cytosine arabinoside, and mitoxantrone: a phase II trial in adults with poor-risk acute myelogenous leukemia.
    Karp JE; Smith BD; Levis MJ; Gore SD; Greer J; Hattenburg C; Briel J; Jones RJ; Wright JJ; Colevas AD
    Clin Cancer Res; 2007 Aug; 13(15 Pt 1):4467-73. PubMed ID: 17671131
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Quantitative analysis of breast cancer resistance protein and cellular resistance to flavopiridol in acute leukemia patients.
    Nakanishi T; Karp JE; Tan M; Doyle LA; Peters T; Yang W; Wei D; Ross DD
    Clin Cancer Res; 2003 Aug; 9(9):3320-8. PubMed ID: 12960118
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Phase I and pharmacokinetic study of flavopiridol followed by 1-beta-D-arabinofuranosylcytosine and mitoxantrone in relapsed and refractory adult acute leukemias.
    Karp JE; Passaniti A; Gojo I; Kaufmann S; Bible K; Garimella TS; Greer J; Briel J; Smith BD; Gore SD; Tidwell ML; Ross DD; Wright JJ; Colevas AD; Bauer KS
    Clin Cancer Res; 2005 Dec; 11(23):8403-12. PubMed ID: 16322302
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Flavopiridol-induced apoptosis is mediated through up-regulation of E2F1 and repression of Mcl-1.
    Ma Y; Cress WD; Haura EB
    Mol Cancer Ther; 2003 Jan; 2(1):73-81. PubMed ID: 12533675
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death.
    Chen R; Keating MJ; Gandhi V; Plunkett W
    Blood; 2005 Oct; 106(7):2513-9. PubMed ID: 15972445
    [TBL] [Abstract][Full Text] [Related]  

  • 13. CDK inhibitors upregulate BH3-only proteins to sensitize human myeloma cells to BH3 mimetic therapies.
    Chen S; Dai Y; Pei XY; Myers J; Wang L; Kramer LB; Garnett M; Schwartz DM; Su F; Simmons GL; Richey JD; Larsen DG; Dent P; Orlowski RZ; Grant S
    Cancer Res; 2012 Aug; 72(16):4225-37. PubMed ID: 22693249
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism.
    Pei XY; Dai Y; Grant S
    Mol Cancer Ther; 2004 Dec; 3(12):1513-24. PubMed ID: 15634644
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Flavopiridol, a cyclin dependent kinase (CDK) inhibitor, induces apoptosis by regulating Bcl-x in oral cancer cells.
    Mihara M; Shintani S; Nakashiro K; Hamakawa H
    Oral Oncol; 2003 Jan; 39(1):49-55. PubMed ID: 12457721
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Flavopiridol displays preclinical activity in acute lymphoblastic leukemia.
    Jackman KM; Frye CB; Hunger SP
    Pediatr Blood Cancer; 2008 Apr; 50(4):772-8. PubMed ID: 18000861
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia.
    Kitada S; Zapata JM; Andreeff M; Reed JC
    Blood; 2000 Jul; 96(2):393-7. PubMed ID: 10887097
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to cyclin-dependent kinase inhibitors in leukemia.
    Yeh YY; Chen R; Hessler J; Mahoney E; Lehman AM; Heerema NA; Grever MR; Plunkett W; Byrd JC; Johnson AJ
    Oncotarget; 2015 Feb; 6(5):2667-79. PubMed ID: 25596730
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines.
    König A; Schwartz GK; Mohammad RM; Al-Katib A; Gabrilove JL
    Blood; 1997 Dec; 90(11):4307-12. PubMed ID: 9373241
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Contribution of disruption of the nuclear factor-kappaB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol.
    Gao N; Dai Y; Rahmani M; Dent P; Grant S
    Mol Pharmacol; 2004 Oct; 66(4):956-63. PubMed ID: 15235103
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.