319 related articles for article (PubMed ID: 21733845)
1. Structural basis of digoxin that antagonizes RORgamma t receptor activity and suppresses Th17 cell differentiation and interleukin (IL)-17 production.
Fujita-Sato S; Ito S; Isobe T; Ohyama T; Wakabayashi K; Morishita K; Ando O; Isono F
J Biol Chem; 2011 Sep; 286(36):31409-17. PubMed ID: 21733845
[TBL] [Abstract][Full Text] [Related]
2. Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity.
Huh JR; Leung MW; Huang P; Ryan DA; Krout MR; Malapaka RR; Chow J; Manel N; Ciofani M; Kim SV; Cuesta A; Santori FR; Lafaille JJ; Xu HE; Gin DY; Rastinejad F; Littman DR
Nature; 2011 Apr; 472(7344):486-90. PubMed ID: 21441909
[TBL] [Abstract][Full Text] [Related]
3. Identification of Tetraazacyclic Compounds as Novel Potent Inhibitors Antagonizing RORγt Activity and Suppressing Th17 Cell Differentiation.
Ding Q; Zhao M; Yu B; Bai C; Huang Z
PLoS One; 2015; 10(9):e0137711. PubMed ID: 26368822
[TBL] [Abstract][Full Text] [Related]
4. Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses.
Ecoeur F; Weiss J; Kaupmann K; Hintermann S; Orain D; Guntermann C
Front Immunol; 2019; 10():577. PubMed ID: 30972071
[TBL] [Abstract][Full Text] [Related]
5. Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms.
Xiao S; Yosef N; Yang J; Wang Y; Zhou L; Zhu C; Wu C; Baloglu E; Schmidt D; Ramesh R; Lobera M; Sundrud MS; Tsai PY; Xiang Z; Wang J; Xu Y; Lin X; Kretschmer K; Rahl PB; Young RA; Zhong Z; Hafler DA; Regev A; Ghosh S; Marson A; Kuchroo VK
Immunity; 2014 Apr; 40(4):477-89. PubMed ID: 24745332
[TBL] [Abstract][Full Text] [Related]
6. Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors.
Li X; Anderson M; Collin D; Muegge I; Wan J; Brennan D; Kugler S; Terenzio D; Kennedy C; Lin S; Labadia ME; Cook B; Hughes R; Farrow NA
J Biol Chem; 2017 Jul; 292(28):11618-11630. PubMed ID: 28546429
[TBL] [Abstract][Full Text] [Related]
7. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand.
Solt LA; Kumar N; Nuhant P; Wang Y; Lauer JL; Liu J; Istrate MA; Kamenecka TM; Roush WR; Vidović D; Schürer SC; Xu J; Wagoner G; Drew PD; Griffin PR; Burris TP
Nature; 2011 Apr; 472(7344):491-4. PubMed ID: 21499262
[TBL] [Abstract][Full Text] [Related]
8. Dehydrodiconiferyl alcohol (DHCA) modulates the differentiation of Th17 and Th1 cells and suppresses experimental autoimmune encephalomyelitis.
Lee J; Choi J; Lee W; Ko K; Kim S
Mol Immunol; 2015 Dec; 68(2 Pt B):434-44. PubMed ID: 26477735
[TBL] [Abstract][Full Text] [Related]
9. Digoxin attenuates acute cardiac allograft rejection by antagonizing RORγt activity.
Wu J; Zhou C; Chen W; Xie A; Li J; Wang S; Ye P; Wang W; Xia J
Transplantation; 2013 Feb; 95(3):434-41. PubMed ID: 23296151
[TBL] [Abstract][Full Text] [Related]
10. Eriodictyol suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis.
Yang T; Li X; Yu J; Deng X; Shen PX; Jiang YB; Zhu L; Wang ZZ; Zhang Y
Food Funct; 2020 Aug; 11(8):6875-6888. PubMed ID: 32686813
[TBL] [Abstract][Full Text] [Related]
11. Inhibition of RORγt activity and Th17 differentiation by a set of novel compounds.
Ding Q; Zhao M; Bai C; Yu B; Huang Z
BMC Immunol; 2015 May; 16():32. PubMed ID: 26021566
[TBL] [Abstract][Full Text] [Related]
12. Pharmacological inhibitory profile of TAK-828F, a potent and selective orally available RORγt inverse agonist.
Shibata A; Uga K; Sato T; Sagara M; Igaki K; Nakamura Y; Ochida A; Kono M; Shirai J; Yamamoto S; Yamasaki M; Tsuchimori N
Biochem Pharmacol; 2018 Apr; 150():35-45. PubMed ID: 29369782
[TBL] [Abstract][Full Text] [Related]
13. Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo.
Guendisch U; Weiss J; Ecoeur F; Riker JC; Kaupmann K; Kallen J; Hintermann S; Orain D; Dawson J; Billich A; Guntermann C
PLoS One; 2017; 12(11):e0188391. PubMed ID: 29155882
[TBL] [Abstract][Full Text] [Related]
14. Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo.
Skepner J; Ramesh R; Trocha M; Schmidt D; Baloglu E; Lobera M; Carlson T; Hill J; Orband-Miller LA; Barnes A; Boudjelal M; Sundrud M; Ghosh S; Yang J
J Immunol; 2014 Mar; 192(6):2564-75. PubMed ID: 24516202
[TBL] [Abstract][Full Text] [Related]
15. Discovery of a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor, S18-000003.
Sasaki Y; Odan M; Yamamoto S; Kida S; Ueyama A; Shimizu M; Haruna T; Watanabe A; Okuno T
Bioorg Med Chem Lett; 2018 Dec; 28(22):3549-3553. PubMed ID: 30301676
[TBL] [Abstract][Full Text] [Related]
16. Immunology: A helping hand against autoimmunity.
Jetten AM
Nature; 2011 Apr; 472(7344):421-2. PubMed ID: 21525918
[TBL] [Abstract][Full Text] [Related]
17. Targeting Th17 Cells with Small Molecules and Small Interference RNA.
Lin H; Song P; Zhao Y; Xue LJ; Liu Y; Chu CQ
Mediators Inflamm; 2015; 2015():290657. PubMed ID: 26792955
[TBL] [Abstract][Full Text] [Related]
18. Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein.
Xu T; Wang X; Zhong B; Nurieva RI; Ding S; Dong C
J Biol Chem; 2011 Jul; 286(26):22707-10. PubMed ID: 21566134
[TBL] [Abstract][Full Text] [Related]
19. Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation.
Soroosh P; Wu J; Xue X; Song J; Sutton SW; Sablad M; Yu J; Nelen MI; Liu X; Castro G; Luna R; Crawford S; Banie H; Dandridge RA; Deng X; Bittner A; Kuei C; Tootoonchi M; Rozenkrants N; Herman K; Gao J; Yang XV; Sachen K; Ngo K; Fung-Leung WP; Nguyen S; de Leon-Tabaldo A; Blevitt J; Zhang Y; Cummings MD; Rao T; Mani NS; Liu C; McKinnon M; Milla ME; Fourie AM; Sun S
Proc Natl Acad Sci U S A; 2014 Aug; 111(33):12163-8. PubMed ID: 25092323
[TBL] [Abstract][Full Text] [Related]
20. Inhibiting RORγt/Th17 axis for autoimmune disorders.
Isono F; Fujita-Sato S; Ito S
Drug Discov Today; 2014 Aug; 19(8):1205-11. PubMed ID: 24792721
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
