143 related articles for article (PubMed ID: 21734321)
1. [Expression systems of cytochrome P450 proteins in studies of drug metabolism in vitro].
Pawłowska M; Augustin E
Postepy Hig Med Dosw (Online); 2011 Jun; 65():367-76. PubMed ID: 21734321
[TBL] [Abstract][Full Text] [Related]
2. Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo-2, LS180) cell lines.
Brandon EF; Bosch TM; Deenen MJ; Levink R; van der Wal E; van Meerveld JB; Bijl M; Beijnen JH; Schellens JH; Meijerman I
Toxicol Appl Pharmacol; 2006 Feb; 211(1):1-10. PubMed ID: 15975613
[TBL] [Abstract][Full Text] [Related]
3. Measurement of Cytochrome P450 Enzyme Induction and Inhibition in Human Hepatoma Cells.
Rodrigues RM; De Kock J; Doktorova TY; Rogiers V; Vanhaecke T
Methods Mol Biol; 2015; 1250():279-85. PubMed ID: 26272150
[TBL] [Abstract][Full Text] [Related]
4. Metronidazole reduces the expression of cytochrome P450 enzymes in HepaRG cells and cryopreserved human hepatocytes.
Kudo T; Endo Y; Taguchi R; Yatsu M; Ito K
Xenobiotica; 2015 May; 45(5):413-9. PubMed ID: 25470432
[TBL] [Abstract][Full Text] [Related]
5. HepaRG cells as human-relevant in vitro model to study the effects of inflammatory stimuli on cytochrome P450 isoenzymes.
Rubin K; Janefeldt A; Andersson L; Berke Z; Grime K; Andersson TB
Drug Metab Dispos; 2015 Jan; 43(1):119-25. PubMed ID: 25371393
[TBL] [Abstract][Full Text] [Related]
6. CYP3A4 expressed by insect cells infected with a recombinant baculovirus containing both CYP3A4 and human NADPH-cytochrome P450 reductase is catalytically similar to human liver microsomal CYP3A4.
Lee CA; Kadwell SH; Kost TA; Serabjit-Singh CJ
Arch Biochem Biophys; 1995 May; 319(1):157-67. PubMed ID: 7771780
[TBL] [Abstract][Full Text] [Related]
7. Cytochrome P450 and the biological clock in mammals.
Froy O
Curr Drug Metab; 2009 Feb; 10(2):104-15. PubMed ID: 19275546
[TBL] [Abstract][Full Text] [Related]
8. Characterization of THLE-cytochrome P450 (P450) cell lines: gene expression background and relationship to P450-enzyme activity.
Soltanpour Y; Hilgendorf C; Ahlström MM; Foster AJ; Kenna JG; Petersen A; Ungell AL
Drug Metab Dispos; 2012 Nov; 40(11):2054-8. PubMed ID: 22851615
[TBL] [Abstract][Full Text] [Related]
9. Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics.
Forrester LM; Henderson CJ; Glancey MJ; Back DJ; Park BK; Ball SE; Kitteringham NR; McLaren AW; Miles JS; Skett P
Biochem J; 1992 Jan; 281 ( Pt 2)(Pt 2):359-68. PubMed ID: 1736885
[TBL] [Abstract][Full Text] [Related]
10. Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil.
Hyland R; Roe EG; Jones BC; Smith DA
Br J Clin Pharmacol; 2001 Mar; 51(3):239-48. PubMed ID: 11298070
[TBL] [Abstract][Full Text] [Related]
11. Potential impact of steatosis on cytochrome P450 enzymes of human hepatocytes isolated from fatty liver grafts.
Donato MT; Lahoz A; Jiménez N; Pérez G; Serralta A; Mir J; Castell JV; Gómez-Lechón MJ
Drug Metab Dispos; 2006 Sep; 34(9):1556-62. PubMed ID: 16763015
[TBL] [Abstract][Full Text] [Related]
12. Epigenetic Modifications of the Liver Tumor Cell Line HepG2 Increase Their Drug Metabolic Capacity.
Ruoß M; Damm G; Vosough M; Ehret L; Grom-Baumgarten C; Petkov M; Naddalin S; Ladurner R; Seehofer D; Nussler A; Sajadian S
Int J Mol Sci; 2019 Jan; 20(2):. PubMed ID: 30654452
[TBL] [Abstract][Full Text] [Related]
13. High levels of recombinant CYP3A4 expression in Chinese hamster ovary cells are modulated by coexpressed human P450 reductase and hemin supplementation.
Ding S; Yao D; Burchell B; Wolf CR; Friedberg T
Arch Biochem Biophys; 1997 Dec; 348(2):403-10. PubMed ID: 9434754
[TBL] [Abstract][Full Text] [Related]
14. Human Hepatic HepaRG Cells Maintain an Organotypic Phenotype with High Intrinsic CYP450 Activity/Metabolism and Significantly Outperform Standard HepG2/C3A Cells for Pharmaceutical and Therapeutic Applications.
Nelson LJ; Morgan K; Treskes P; Samuel K; Henderson CJ; LeBled C; Homer N; Grant MH; Hayes PC; Plevris JN
Basic Clin Pharmacol Toxicol; 2017 Jan; 120(1):30-37. PubMed ID: 27285124
[TBL] [Abstract][Full Text] [Related]
15. Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: role in intrauterine toxicity.
Hakkola J; Pelkonen O; Pasanen M; Raunio H
Crit Rev Toxicol; 1998 Jan; 28(1):35-72. PubMed ID: 9493761
[TBL] [Abstract][Full Text] [Related]
16. Cytochrome P450-dependent metabolism in HepaRG cells cultured in a dynamic three-dimensional bioreactor.
Darnell M; Schreiter T; Zeilinger K; Urbaniak T; Söderdahl T; Rossberg I; Dillnér B; Berg AL; Gerlach JC; Andersson TB
Drug Metab Dispos; 2011 Jul; 39(7):1131-8. PubMed ID: 21436404
[TBL] [Abstract][Full Text] [Related]
17. In vitro characterization of the metabolism of haloperidol using recombinant cytochrome p450 enzymes and human liver microsomes.
Fang J; McKay G; Song J; Remillrd A; Li X; Midha K
Drug Metab Dispos; 2001 Dec; 29(12):1638-43. PubMed ID: 11717183
[TBL] [Abstract][Full Text] [Related]
18. In vitro assessment of the allelic variants of cytochrome P450.
Hiratsuka M
Drug Metab Pharmacokinet; 2012; 27(1):68-84. PubMed ID: 22041138
[TBL] [Abstract][Full Text] [Related]
19. N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine (DPPE) a chemopotentiating and cytoprotective agent in clinical trials: interaction with histamine at cytochrome P450 3A4 and other isozymes that metabolize antineoplastic drugs.
Brandes LJ; Queen GM; LaBella FS
Cancer Chemother Pharmacol; 2000; 45(4):298-304. PubMed ID: 10755318
[TBL] [Abstract][Full Text] [Related]
20. In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies.
Wang L; Zhang D; Raghavan N; Yao M; Ma L; Frost CE; Maxwell BD; Chen SY; He K; Goosen TC; Humphreys WG; Grossman SJ
Drug Metab Dispos; 2010 Mar; 38(3):448-58. PubMed ID: 19940026
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
