BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

207 related articles for article (PubMed ID: 2173561)

  • 1. Role of the conserved amino acids of the 'SDN' loop (Ser130, Asp131 and Asn132) in a class A beta-lactamase studied by site-directed mutagenesis.
    Jacob F; Joris B; Lepage S; Dusart J; Frère JM
    Biochem J; 1990 Oct; 271(2):399-406. PubMed ID: 2173561
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Active-site serine mutants of the Streptomyces albus G beta-lactamase.
    Jacob F; Joris B; Frère JM
    Biochem J; 1991 Aug; 277 ( Pt 3)(Pt 3):647-52. PubMed ID: 1908220
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Site-directed mutagenesis of the Streptomyces R61 DD-peptidase. Catalytic function of the conserved residues around the active site and a comparison with class-A and class-C beta-lactamases.
    Hadonou AM; Wilkin JM; Varetto L; Joris B; Lamotte-Brasseur J; Klein D; Duez C; Ghuysen JM; Frère JM
    Eur J Biochem; 1992 Jul; 207(1):97-102. PubMed ID: 1628665
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Catalytic mechanism of active-site serine beta-lactamases: role of the conserved hydroxy group of the Lys-Thr(Ser)-Gly triad.
    Dubus A; Wilkin JM; Raquet X; Normark S; Frère JM
    Biochem J; 1994 Jul; 301 ( Pt 2)(Pt 2):485-94. PubMed ID: 8042993
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibitor-resistant class A beta-lactamases: consequences of the Ser130-to-Gly mutation seen in Apo and tazobactam structures of the SHV-1 variant.
    Sun T; Bethel CR; Bonomo RA; Knox JR
    Biochemistry; 2004 Nov; 43(44):14111-7. PubMed ID: 15518561
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibition of AmpC beta-lactamase through a destabilizing interaction in the active site.
    Trehan I; Beadle BM; Shoichet BK
    Biochemistry; 2001 Jul; 40(27):7992-9. PubMed ID: 11434768
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-function analysis of alpha-helix H4 using PSE-4 as a model enzyme representative of class A beta-lactamases.
    Savoie A; Sanschagrin F; Palzkill T; Voyer N; Levesque RC
    Protein Eng; 2000 Apr; 13(4):267-74. PubMed ID: 10810158
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Site-saturation mutagenesis and three-dimensional modelling of ROB-1 define a substrate binding role of Ser130 in class A beta-lactamases.
    Juteau JM; Billings E; Knox JR; Levesque RC
    Protein Eng; 1992 Oct; 5(7):693-701. PubMed ID: 1480622
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The mutation Lys234His yields a class A beta-lactamase with a novel pH-dependence.
    Brannigan J; Matagne A; Jacob F; Damblon C; Joris B; Klein D; Spratt BG; Frère JM
    Biochem J; 1991 Sep; 278 ( Pt 3)(Pt 3):673-8. PubMed ID: 1910335
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Streptomyces albus G serine beta-lactamase. Probing of the catalytic mechanism via molecular modelling of mutant enzymes.
    Lamotte-Brasseur J; Jacob-Dubuisson F; Dive G; Frère JM; Ghuysen JM
    Biochem J; 1992 Feb; 282 ( Pt 1)(Pt 1):189-95. PubMed ID: 1540134
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Role of Ser-238 and Lys-240 in the hydrolysis of third-generation cephalosporins by SHV-type beta-lactamases probed by site-directed mutagenesis and three-dimensional modeling.
    Huletsky A; Knox JR; Levesque RC
    J Biol Chem; 1993 Feb; 268(5):3690-7. PubMed ID: 8429044
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Substitution of Asp for Asn at position 132 in the active site of TEM beta-lactamase. Activity toward different substrates and effects of neighboring residues.
    Osuna J; Viadiu H; Fink AL; Soberón X
    J Biol Chem; 1995 Jan; 270(2):775-80. PubMed ID: 7822310
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Engineering a novel beta-lactamase by a single point mutation.
    Jacob F; Joris B; Dideberg O; Dusart J; Ghuysen JM; Frère JM
    Protein Eng; 1990 Oct; 4(1):79-86. PubMed ID: 2127105
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Site-directed mutagenesis at the active site of Escherichia coli TEM-1 beta-lactamase. Suicide inhibitor-resistant mutants reveal the role of arginine 244 and methionine 69 in catalysis.
    Delaire M; Labia R; Samama JP; Masson JM
    J Biol Chem; 1992 Oct; 267(29):20600-6. PubMed ID: 1400382
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Investigating the role of conserved residue Asp134 in Escherichia coli ribonuclease HI by site-directed random mutagenesis.
    Haruki M; Noguchi E; Nakai C; Liu YY; Oobatake M; Itaya M; Kanaya S
    Eur J Biochem; 1994 Mar; 220(2):623-31. PubMed ID: 8125123
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Arginine 220 is a critical residue for the catalytic mechanism of the Streptomyces albus G beta-lactamase.
    Jacob-Dubuisson F; Lamotte-Brasseur J; Dideberg O; Joris B; Frère JM
    Protein Eng; 1991 Oct; 4(7):811-9. PubMed ID: 1798704
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Role of residues 104, 164, 166, 238 and 240 in the substrate profile of PER-1 beta-lactamase hydrolysing third-generation cephalosporins.
    Bouthors AT; Dagoneau-Blanchard N; Naas T; Nordmann P; Jarlier V; Sougakoff W
    Biochem J; 1998 Mar; 330 ( Pt 3)(Pt 3):1443-9. PubMed ID: 9494118
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mechanism of action of DD-peptidases: role of asparagine-161 in the Streptomyces R61 DD-peptidase.
    Wilkin JM; Jamin M; Joris B; Frere JM
    Biochem J; 1993 Jul; 293 ( Pt 1)(Pt 1):195-201. PubMed ID: 8328960
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Site-directed mutagenesis of glutamate 166 in two beta-lactamases. Kinetic and molecular modeling studies.
    Guillaume G; Vanhove M; Lamotte-Brasseur J; Ledent P; Jamin M; Joris B; Frère JM
    J Biol Chem; 1997 Feb; 272(9):5438-44. PubMed ID: 9038144
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The role of the non-conserved residue at position 104 of class A beta-lactamases in susceptibility to mechanism-based inhibitors.
    Guo F; Huynh J; Dmitrienko GI; Viswanatha T; Clarke AJ
    Biochim Biophys Acta; 1999 Apr; 1431(1):132-47. PubMed ID: 10209286
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.