259 related articles for article (PubMed ID: 21738705)
1. Regulation of mTORC1 signaling by pH.
Balgi AD; Diering GH; Donohue E; Lam KK; Fonseca BD; Zimmerman C; Numata M; Roberge M
PLoS One; 2011; 6(6):e21549. PubMed ID: 21738705
[TBL] [Abstract][Full Text] [Related]
2. Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia.
Wolff NC; Vega-Rubin-de-Celis S; Xie XJ; Castrillon DH; Kabbani W; Brugarolas J
Mol Cell Biol; 2011 May; 31(9):1870-84. PubMed ID: 21383064
[TBL] [Abstract][Full Text] [Related]
3. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.
Zhang HH; Huang J; Düvel K; Boback B; Wu S; Squillace RM; Wu CL; Manning BD
PLoS One; 2009 Jul; 4(7):e6189. PubMed ID: 19593385
[TBL] [Abstract][Full Text] [Related]
4. Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling.
Stevens C; Lin Y; Harrison B; Burch L; Ridgway RA; Sansom O; Hupp T
J Biol Chem; 2009 Jan; 284(1):334-344. PubMed ID: 18974095
[TBL] [Abstract][Full Text] [Related]
5. ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signaling.
Winter JN; Jefferson LS; Kimball SR
Am J Physiol Cell Physiol; 2011 May; 300(5):C1172-80. PubMed ID: 21289294
[TBL] [Abstract][Full Text] [Related]
6. mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization.
Gan B; Sahin E; Jiang S; Sanchez-Aguilera A; Scott KL; Chin L; Williams DA; Kwiatkowski DJ; DePinho RA
Proc Natl Acad Sci U S A; 2008 Dec; 105(49):19384-9. PubMed ID: 19052232
[TBL] [Abstract][Full Text] [Related]
7. The TSC1-TSC2 complex is required for proper activation of mTOR complex 2.
Huang J; Dibble CC; Matsuzaki M; Manning BD
Mol Cell Biol; 2008 Jun; 28(12):4104-15. PubMed ID: 18411301
[TBL] [Abstract][Full Text] [Related]
8. cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity.
Xie J; Ponuwei GA; Moore CE; Willars GB; Tee AR; Herbert TP
Cell Signal; 2011 Dec; 23(12):1927-35. PubMed ID: 21763421
[TBL] [Abstract][Full Text] [Related]
9. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.
Dibble CC; Elis W; Menon S; Qin W; Klekota J; Asara JM; Finan PM; Kwiatkowski DJ; Murphy LO; Manning BD
Mol Cell; 2012 Aug; 47(4):535-46. PubMed ID: 22795129
[TBL] [Abstract][Full Text] [Related]
10. Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response.
Babcock JT; Nguyen HB; He Y; Hendricks JW; Wek RC; Quilliam LA
J Biol Chem; 2013 May; 288(22):15687-98. PubMed ID: 23612979
[TBL] [Abstract][Full Text] [Related]
11. Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors.
Huang J; Wu S; Wu CL; Manning BD
Cancer Res; 2009 Aug; 69(15):6107-14. PubMed ID: 19602587
[TBL] [Abstract][Full Text] [Related]
12. TSC1 controls distribution of actin fibers through its effect on function of Rho family of small GTPases and regulates cell migration and polarity.
Ohsawa M; Kobayashi T; Okura H; Igarashi T; Mizuguchi M; Hino O
PLoS One; 2013; 8(1):e54503. PubMed ID: 23355874
[TBL] [Abstract][Full Text] [Related]
13. Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling.
Miyazaki M; McCarthy JJ; Fedele MJ; Esser KA
J Physiol; 2011 Apr; 589(Pt 7):1831-46. PubMed ID: 21300751
[TBL] [Abstract][Full Text] [Related]
14. Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex 1.
Tanwar PS; Kaneko-Tarui T; Zhang L; Tanaka Y; Crum CP; Teixeira JM
PLoS Genet; 2012; 8(8):e1002906. PubMed ID: 22916036
[TBL] [Abstract][Full Text] [Related]
15. Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin.
Malhowski AJ; Hira H; Bashiruddin S; Warburton R; Goto J; Robert B; Kwiatkowski DJ; Finlay GA
Hum Mol Genet; 2011 Apr; 20(7):1290-305. PubMed ID: 21212099
[TBL] [Abstract][Full Text] [Related]
16. Upregulation of 6-phosphofructo-2-kinase (PFKFB3) by hyperactivated mammalian target of rapamycin complex 1 is critical for tumor growth in tuberous sclerosis complex.
Wang Y; Tang S; Wu Y; Wan X; Zhou M; Li H; Zha X
IUBMB Life; 2020 May; 72(5):965-977. PubMed ID: 31958214
[TBL] [Abstract][Full Text] [Related]
17. The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.
Kang YJ; Lu MK; Guan KL
Cell Death Differ; 2011 Jan; 18(1):133-44. PubMed ID: 20616807
[TBL] [Abstract][Full Text] [Related]
18. Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells.
Chen W; Pan Y; Wang S; Liu Y; Chen G; Zhou L; Ni W; Wang A; Lu Y
BMC Cancer; 2017 Jan; 17(1):34. PubMed ID: 28061838
[TBL] [Abstract][Full Text] [Related]
19. Hyperactivation of mammalian target of rapamycin complex 1 (mTORC1) promotes breast cancer progression through enhancing glucose starvation-induced autophagy and Akt signaling.
Chen Y; Wei H; Liu F; Guan JL
J Biol Chem; 2014 Jan; 289(2):1164-73. PubMed ID: 24275666
[TBL] [Abstract][Full Text] [Related]
20. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.
Huang J; Manning BD
Biochem J; 2008 Jun; 412(2):179-90. PubMed ID: 18466115
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
