These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
138 related articles for article (PubMed ID: 21742495)
1. Pyridine-derived γ-secretase modulators. Wan Z; Hall A; Sang Y; Xiang JN; Yang E; Smith B; Harrison DC; Yang G; Yu H; Price HS; Wang J; Hawkins J; Lau LF; Johnson MR; Li T; Zhao W; Mitchell WL; Su X; Zhang X; Zhou Y; Jin Y; Tong Z; Cheng Z; Hussain I; Elliott JD; Matsuoka Y Bioorg Med Chem Lett; 2011 Aug; 21(16):4832-5. PubMed ID: 21742495 [TBL] [Abstract][Full Text] [Related]
2. Pyridazine-derived γ-secretase modulators. Wan Z; Hall A; Jin Y; Xiang JN; Yang E; Eatherton A; Smith B; Yang G; Yu H; Wang J; Ye L; Lau LF; Yang T; Mitchell W; Cai W; Zhang X; Sang Y; Wang Y; Tong Z; Cheng Z; Hussain I; Elliott JD; Matsuoka Y Bioorg Med Chem Lett; 2011 Jul; 21(13):4016-9. PubMed ID: 21636276 [TBL] [Abstract][Full Text] [Related]
3. Orally bioavailable and brain-penetrant pyridazine and pyridine-derived γ-secretase modulators reduced amyloidogenic Aβ peptides in vivo. Huang Y; Li T; Eatherton A; Mitchell WL; Rong N; Ye L; Yang XJ; Jin S; Ding Y; Zhang J; Li Y; Wu Y; Jin Y; Sang Y; Cheng Z; Browne ER; Harrison DC; Hussain I; Wan Z; Hall A; Lau LF; Matsuoka Y Neuropharmacology; 2013 Jul; 70():278-86. PubMed ID: 23485401 [TBL] [Abstract][Full Text] [Related]
4. Piperidine-derived gamma-secretase modulators. Hall A; Elliott RL; Giblin GM; Hussain I; Musgrave J; Naylor A; Sasse R; Smith B Bioorg Med Chem Lett; 2010 Feb; 20(3):1306-11. PubMed ID: 20056541 [TBL] [Abstract][Full Text] [Related]
5. Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators. Rynearson KD; Buckle RN; Herr RJ; Mayhew NJ; Chen X; Paquette WD; Sakwa SA; Yang J; Barnes KD; Nguyen P; Mobley WC; Johnson G; Lin JH; Tanzi RE; Wagner SL Bioorg Med Chem; 2020 Nov; 28(22):115734. PubMed ID: 33007551 [TBL] [Abstract][Full Text] [Related]
6. Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators (Part 2). Takai T; Koike T; Nakamura M; Kajita Y; Yamashita T; Taya N; Tsukamoto T; Watanabe T; Murakami K; Igari T; Kamata M Bioorg Med Chem; 2016 Jul; 24(14):3192-206. PubMed ID: 27255179 [TBL] [Abstract][Full Text] [Related]
7. Diamide amino-imidazoles: a novel series of γ-secretase inhibitors for the treatment of Alzheimer's disease. Brodney MA; Auperin DD; Becker SL; Bronk BS; Brown TM; Coffman KJ; Finley JE; Hicks CD; Karmilowicz MJ; Lanz TA; Liston D; Liu X; Martin BA; Nelson RB; Nolan CE; Oborski CE; Parker CP; Richter KE; Pozdnyakov N; Sahagan BG; Schachter JB; Sokolowski SA; Tate B; Van Deusen JW; Wood DE; Wood KM Bioorg Med Chem Lett; 2011 May; 21(9):2631-6. PubMed ID: 21269825 [TBL] [Abstract][Full Text] [Related]
8. Structural optimization of a CXCR2-directed antagonist that indirectly inhibits gamma-secretase and reduces Abeta. Bakshi P; Jin C; Broutin P; Berhane B; Reed J; Mullan M Bioorg Med Chem; 2009 Dec; 17(23):8102-12. PubMed ID: 19853461 [TBL] [Abstract][Full Text] [Related]
9. Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors. Aubele DL; Truong AP; Dressen DB; Probst GD; Bowers S; Mattson MN; Semko CM; Sun M; Garofalo AW; Konradi AW; Sham HL; Zmolek W; Wong K; Goldbach E; Quinn KP; Sauer JM; Brigham EF; Wallace W; Nguyen L; Bova MP; Hemphill SS; Basi G Bioorg Med Chem Lett; 2011 Oct; 21(19):5791-4. PubMed ID: 21885276 [TBL] [Abstract][Full Text] [Related]
10. Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators. Pettersson M; Johnson DS; Subramanyam C; Bales KR; am Ende CW; Fish BA; Green ME; Kauffman GW; Lira R; Mullins PB; Navaratnam T; Sakya SM; Stiff CM; Tran TP; Vetelino BC; Xie L; Zhang L; Pustilnik LR; Wood KM; O'Donnell CJ Bioorg Med Chem Lett; 2012 Apr; 22(8):2906-11. PubMed ID: 22429469 [TBL] [Abstract][Full Text] [Related]
11. Ex vivo occupancy of gamma-secretase inhibitors correlates with brain beta-amyloid peptide reduction in Tg2576 mice. Goldstein ME; Cao Y; Fiedler T; Toyn J; Iben L; Barten DM; Pierdomenico M; Corsa J; Prasad CV; Olson RE; Li YW; Zaczek R; Albright CF J Pharmacol Exp Ther; 2007 Oct; 323(1):102-8. PubMed ID: 17640949 [TBL] [Abstract][Full Text] [Related]
12. Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease. Mayer SC; Kreft AF; Harrison B; Abou-Gharbia M; Antane M; Aschmies S; Atchison K; Chlenov M; Cole DC; Comery T; Diamantidis G; Ellingboe J; Fan K; Galante R; Gonzales C; Ho DM; Hoke ME; Hu Y; Huryn D; Jain U; Jin M; Kremer K; Kubrak D; Lin M; Lu P; Magolda R; Martone R; Moore W; Oganesian A; Pangalos MN; Porte A; Reinhart P; Resnick L; Riddell DR; Sonnenberg-Reines J; Stock JR; Sun SC; Wagner E; Wang T; Woller K; Xu Z; Zaleska MM; Zeldis J; Zhang M; Zhou H; Jacobsen JS J Med Chem; 2008 Dec; 51(23):7348-51. PubMed ID: 19012391 [TBL] [Abstract][Full Text] [Related]
13. Triazoles as γ-secretase modulators. Fischer C; Zultanski SL; Zhou H; Methot JL; Brown WC; Mampreian DM; Schell AJ; Shah S; Nuthall H; Hughes BL; Smotrov N; Kenific CM; Cruz JC; Walker D; Bouthillette M; Nikov GN; Savage DF; Jeliazkova-Mecheva VV; Diaz D; Szewczak AA; Bays N; Middleton RE; Munoz B; Shearman MS Bioorg Med Chem Lett; 2011 Jul; 21(13):4083-7. PubMed ID: 21616665 [TBL] [Abstract][Full Text] [Related]
14. Synthesis and SAR study of tricyclic sulfones as γ-secretase inhibitors: C-6 and C-8 positions. Su J; Tang H; McKittrick BA; Xu R; Clader JW; Greenlee WJ; Hyde L; Zhang L Bioorg Med Chem Lett; 2011 Jun; 21(11):3447-51. PubMed ID: 21515050 [TBL] [Abstract][Full Text] [Related]
15. 4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors. Churcher I; Beher D; Best JD; Castro JL; Clarke EE; Gentry A; Harrison T; Hitzel L; Kay E; Kerrad S; Lewis HD; Morentin-Gutierrez P; Mortishire-Smith R; Oakley PJ; Reilly M; Shaw DE; Shearman MS; Teall MR; Williams S; Wrigley JD Bioorg Med Chem Lett; 2006 Jan; 16(2):280-4. PubMed ID: 16275079 [TBL] [Abstract][Full Text] [Related]
16. Dynamics of Aβ42 reduction in plasma, CSF and brain of rats treated with the γ-secretase modulator, GSM-10h. Hawkins J; Harrison DC; Ahmed S; Davis RP; Chapman T; Marshall I; Smith B; Mead TL; Medhurst A; Giblin GM; Hall A; Gonzalez MI; Richardson J; Hussain I Neurodegener Dis; 2011; 8(6):455-64. PubMed ID: 21389687 [TBL] [Abstract][Full Text] [Related]
17. Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer's disease. Neitzel ML; Aubele DL; Marugg JL; Jagodzinski JJ; Konradi AW; Pleiss MA; Szoke B; Zmolek W; Goldbach E; Quinn KP; Sauer JM; Brigham EF; Wallace W; Bova MP; Hemphill S; Basi G Bioorg Med Chem Lett; 2011 Jun; 21(12):3715-20. PubMed ID: 21571529 [TBL] [Abstract][Full Text] [Related]
18. SAR studies of acidic dual γ-secretase/PPARγ modulators. Hieke M; Ness J; Steri R; Greiner C; Werz O; Schubert-Zsilavecz M; Weggen S; Zettl H Bioorg Med Chem; 2011 Sep; 19(18):5372-82. PubMed ID: 21873070 [TBL] [Abstract][Full Text] [Related]
19. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883 [TBL] [Abstract][Full Text] [Related]
20. Discovery of a novel series of Notch-sparing gamma-secretase inhibitors. Kreft A; Harrison B; Aschmies S; Atchison K; Casebier D; Cole DC; Diamantidis G; Ellingboe J; Hauze D; Hu Y; Huryn D; Jin M; Kubrak D; Lu P; Lundquist J; Mann C; Martone R; Moore W; Oganesian A; Porte A; Riddell DR; Sonnenberg-Reines J; Stock JR; Sun SC; Wagner E; Woller K; Xu Z; Zhou H; Steven Jacobsen J Bioorg Med Chem Lett; 2008 Jul; 18(14):4232-6. PubMed ID: 18556202 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]