528 related articles for article (PubMed ID: 21743462)
1. A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.
Vedadi M; Barsyte-Lovejoy D; Liu F; Rival-Gervier S; Allali-Hassani A; Labrie V; Wigle TJ; Dimaggio PA; Wasney GA; Siarheyeva A; Dong A; Tempel W; Wang SC; Chen X; Chau I; Mangano TJ; Huang XP; Simpson CD; Pattenden SG; Norris JL; Kireev DB; Tripathy A; Edwards A; Roth BL; Janzen WP; Garcia BA; Petronis A; Ellis J; Brown PJ; Frye SV; Arrowsmith CH; Jin J
Nat Chem Biol; 2011 Jul; 7(8):566-74. PubMed ID: 21743462
[TBL] [Abstract][Full Text] [Related]
2. Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.
Liu F; Barsyte-Lovejoy D; Li F; Xiong Y; Korboukh V; Huang XP; Allali-Hassani A; Janzen WP; Roth BL; Frye SV; Arrowsmith CH; Brown PJ; Vedadi M; Jin J
J Med Chem; 2013 Nov; 56(21):8931-42. PubMed ID: 24102134
[TBL] [Abstract][Full Text] [Related]
3. G9a/GLP-dependent histone H3K9me2 patterning during human hematopoietic stem cell lineage commitment.
Chen X; Skutt-Kakaria K; Davison J; Ou YL; Choi E; Malik P; Loeb K; Wood B; Georges G; Torok-Storb B; Paddison PJ
Genes Dev; 2012 Nov; 26(22):2499-511. PubMed ID: 23105005
[TBL] [Abstract][Full Text] [Related]
4. G9a/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation.
Gupta-Agarwal S; Franklin AV; Deramus T; Wheelock M; Davis RL; McMahon LL; Lubin FD
J Neurosci; 2012 Apr; 32(16):5440-53. PubMed ID: 22514307
[TBL] [Abstract][Full Text] [Related]
5. Histone lysine methyltransferase G9a is a novel epigenetic target for the treatment of hepatocellular carcinoma.
Yokoyama M; Chiba T; Zen Y; Oshima M; Kusakabe Y; Noguchi Y; Yuki K; Koide S; Tara S; Saraya A; Aoyama K; Mimura N; Miyagi S; Inoue M; Wakamatsu T; Saito T; Ogasawara S; Suzuki E; Ooka Y; Tawada A; Otsuka M; Miyazaki M; Yokosuka O; Iwama A
Oncotarget; 2017 Mar; 8(13):21315-21326. PubMed ID: 28423509
[TBL] [Abstract][Full Text] [Related]
6. The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia.
Pappano WN; Guo J; He Y; Ferguson D; Jagadeeswaran S; Osterling DJ; Gao W; Spence JK; Pliushchev M; Sweis RF; Buchanan FG; Michaelides MR; Shoemaker AR; Tse C; Chiang GG
PLoS One; 2015; 10(7):e0131716. PubMed ID: 26147105
[TBL] [Abstract][Full Text] [Related]
7. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.
Kubicek S; O'Sullivan RJ; August EM; Hickey ER; Zhang Q; Teodoro ML; Rea S; Mechtler K; Kowalski JA; Homon CA; Kelly TA; Jenuwein T
Mol Cell; 2007 Feb; 25(3):473-81. PubMed ID: 17289593
[TBL] [Abstract][Full Text] [Related]
8. Histone methyltransferase G9a and H3K9 dimethylation inhibit the self-renewal of glioma cancer stem cells.
Tao H; Li H; Su Y; Feng D; Wang X; Zhang C; Ma H; Hu Q
Mol Cell Biochem; 2014 Sep; 394(1-2):23-30. PubMed ID: 24833465
[TBL] [Abstract][Full Text] [Related]
9. Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.
Xiong Y; Li F; Babault N; Dong A; Zeng H; Wu H; Chen X; Arrowsmith CH; Brown PJ; Liu J; Vedadi M; Jin J
J Med Chem; 2017 Mar; 60(5):1876-1891. PubMed ID: 28135087
[TBL] [Abstract][Full Text] [Related]
10. Distinct roles for histone methyltransferases G9a and GLP in cancer germ-line antigen gene regulation in human cancer cells and murine embryonic stem cells.
Link PA; Gangisetty O; James SR; Woloszynska-Read A; Tachibana M; Shinkai Y; Karpf AR
Mol Cancer Res; 2009 Jun; 7(6):851-62. PubMed ID: 19531572
[TBL] [Abstract][Full Text] [Related]
11. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines.
Liu F; Barsyte-Lovejoy D; Allali-Hassani A; He Y; Herold JM; Chen X; Yates CM; Frye SV; Brown PJ; Huang J; Vedadi M; Arrowsmith CH; Jin J
J Med Chem; 2011 Sep; 54(17):6139-50. PubMed ID: 21780790
[TBL] [Abstract][Full Text] [Related]
12. The histone H3 lysine 9 methyltransferase G9a/GLP complex activity is required for long-term consolidation of spatial memory in mice.
Nicolay-Kritter K; Lassalle J; Guillou JL; Mons N
Neurobiol Learn Mem; 2021 Mar; 179():107406. PubMed ID: 33609736
[TBL] [Abstract][Full Text] [Related]
13. Structure-activity relationship studies of G9a-like protein (GLP) inhibitors.
Xiong Y; Li F; Babault N; Wu H; Dong A; Zeng H; Chen X; Arrowsmith CH; Brown PJ; Liu J; Vedadi M; Jin J
Bioorg Med Chem; 2017 Aug; 25(16):4414-4423. PubMed ID: 28662962
[TBL] [Abstract][Full Text] [Related]
14. Inhibition of H3K9 methyltransferases G9a/GLP prevents ototoxicity and ongoing hair cell death.
Yu H; Lin Q; Wang Y; He Y; Fu S; Jiang H; Yu Y; Sun S; Chen Y; Shou J; Li H
Cell Death Dis; 2013 Feb; 4(2):e506. PubMed ID: 23429292
[TBL] [Abstract][Full Text] [Related]
15. Inhibition of G9a/GLP Complex Promotes Long-Term Potentiation and Synaptic Tagging/Capture in Hippocampal CA1 Pyramidal Neurons.
Sharma M; Razali NB; Sajikumar S
Cereb Cortex; 2017 Jun; 27(6):3161-3171. PubMed ID: 27252354
[TBL] [Abstract][Full Text] [Related]
16. Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice.
Subbanna S; Nagre NN; Shivakumar M; Umapathy NS; Psychoyos D; Basavarajappa BS
Neuroscience; 2014 Jan; 258():422-32. PubMed ID: 24300108
[TBL] [Abstract][Full Text] [Related]
17. Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader-Willi syndrome.
Kim Y; Lee HM; Xiong Y; Sciaky N; Hulbert SW; Cao X; Everitt JI; Jin J; Roth BL; Jiang YH
Nat Med; 2017 Feb; 23(2):213-222. PubMed ID: 28024084
[TBL] [Abstract][Full Text] [Related]
18. Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.
Chang Y; Zhang X; Horton JR; Upadhyay AK; Spannhoff A; Liu J; Snyder JP; Bedford MT; Cheng X
Nat Struct Mol Biol; 2009 Mar; 16(3):312-7. PubMed ID: 19219047
[TBL] [Abstract][Full Text] [Related]
19. Effects of the histone methyltransferase inhibitor UNC0638 on histone H3K9 dimethylation of cultured ovine somatic cells and development of resulting early cloned embryos.
Fu L; Yan FX; An XR; Hou J
Reprod Domest Anim; 2014 Apr; 49(2):e21-5. PubMed ID: 24467723
[TBL] [Abstract][Full Text] [Related]
20. Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.
Tachibana M; Ueda J; Fukuda M; Takeda N; Ohta T; Iwanari H; Sakihama T; Kodama T; Hamakubo T; Shinkai Y
Genes Dev; 2005 Apr; 19(7):815-26. PubMed ID: 15774718
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]