166 related articles for article (PubMed ID: 21745101)
1. Small-molecule thyrotropin receptor agonist activates naturally occurring thyrotropin-insensitive mutants and reveals their distinct cyclic adenosine monophosphate signal persistence.
Allen MD; Neumann S; Gershengorn MC
Thyroid; 2011 Aug; 21(8):907-12. PubMed ID: 21745101
[TBL] [Abstract][Full Text] [Related]
2. Occupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling.
Allen MD; Neumann S; Gershengorn MC
FASEB J; 2011 Oct; 25(10):3687-94. PubMed ID: 21705666
[TBL] [Abstract][Full Text] [Related]
3. Substitutions of different regions of the third cytoplasmic loop of the thyrotropin (TSH) receptor have selective effects on constitutive, TSH-, and TSH receptor autoantibody-stimulated phosphoinositide and 3',5'-cyclic adenosine monophosphate signal generation.
Kosugi S; Okajima F; Ban T; Hidaka A; Shenker A; Kohn LD
Mol Endocrinol; 1993 Aug; 7(8):1009-20. PubMed ID: 7901757
[TBL] [Abstract][Full Text] [Related]
4. Germline mutations of TSH receptor gene as cause of nonautoimmune subclinical hypothyroidism.
Alberti L; Proverbio MC; Costagliola S; Romoli R; Boldrighini B; Vigone MC; Weber G; Chiumello G; Beck-Peccoz P; Persani L
J Clin Endocrinol Metab; 2002 Jun; 87(6):2549-55. PubMed ID: 12050212
[TBL] [Abstract][Full Text] [Related]
5. Persistent cAMP signaling by TSH receptors revealed by phosphodiesterase inhibition.
Geras-Raaka E; Neumann S; Gershengorn MC
Thyroid; 2013 Nov; 23(11):1484-9. PubMed ID: 23713896
[TBL] [Abstract][Full Text] [Related]
6. Persistent cAMP signaling by thyrotropin (TSH) receptors is not dependent on internalization.
Neumann S; Geras-Raaka E; Marcus-Samuels B; Gershengorn MC
FASEB J; 2010 Oct; 24(10):3992-9. PubMed ID: 20538910
[TBL] [Abstract][Full Text] [Related]
7. A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
Neumann S; Huang W; Eliseeva E; Titus S; Thomas CJ; Gershengorn MC
Endocrinology; 2010 Jul; 151(7):3454-9. PubMed ID: 20427476
[TBL] [Abstract][Full Text] [Related]
8. Thyrotropin receptor stimulates internalization-independent persistent phosphoinositide signaling.
Boutin A; Allen MD; Geras-Raaka E; Huang W; Neumann S; Gershengorn MC
Mol Pharmacol; 2011 Aug; 80(2):240-6. PubMed ID: 21525174
[TBL] [Abstract][Full Text] [Related]
9. Thyrotropin Causes Dose-dependent Biphasic Regulation of cAMP Production Mediated by G
Neumann S; Malik SS; Marcus-Samuels B; Eliseeva E; Jang D; Klubo-Gwiezdzinska J; Krieger CC; Gershengorn MC
Mol Pharmacol; 2020 Jan; 97(1):2-8. PubMed ID: 31704717
[TBL] [Abstract][Full Text] [Related]
10. A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor.
Neumann S; Eliseeva E; McCoy JG; Napolitano G; Giuliani C; Monaco F; Huang W; Gershengorn MC
J Clin Endocrinol Metab; 2011 Feb; 96(2):548-54. PubMed ID: 21123444
[TBL] [Abstract][Full Text] [Related]
11. Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice.
Neumann S; Huang W; Titus S; Krause G; Kleinau G; Alberobello AT; Zheng W; Southall NT; Inglese J; Austin CP; Celi FS; Gavrilova O; Thomas CJ; Raaka BM; Gershengorn MC
Proc Natl Acad Sci U S A; 2009 Jul; 106(30):12471-6. PubMed ID: 19592511
[TBL] [Abstract][Full Text] [Related]
12. Persistent cAMP signaling by internalized TSH receptors occurs in thyroid but not in HEK293 cells.
Werthmann RC; Volpe S; Lohse MJ; Calebiro D
FASEB J; 2012 May; 26(5):2043-8. PubMed ID: 22291442
[TBL] [Abstract][Full Text] [Related]
13. The middle portion in the second cytoplasmic loop of the thyrotropin receptor plays a crucial role in adenylate cyclase activation.
Kosugi S; Kohn LD; Akamizu T; Mori T
Mol Endocrinol; 1994 Apr; 8(4):498-509. PubMed ID: 7914349
[TBL] [Abstract][Full Text] [Related]
14. A familial thyrotropin (TSH) receptor mutation provides in vivo evidence that the inositol phosphates/Ca2+ cascade mediates TSH action on thyroid hormone synthesis.
Grasberger H; Van Sande J; Hag-Dahood Mahameed A; Tenenbaum-Rakover Y; Refetoff S
J Clin Endocrinol Metab; 2007 Jul; 92(7):2816-20. PubMed ID: 17456567
[TBL] [Abstract][Full Text] [Related]
15. Exosomes Expressing Thyrotropin Receptor Attenuate Autoantibody-Mediated Stimulation of Cyclic Adenosine Monophosphate Production.
Edo N; Kawakami K; Fujita Y; Morita K; Uno K; Tsukamoto K; Onose H; Ishikawa T; Ito M
Thyroid; 2019 Jul; 29(7):1012-1017. PubMed ID: 31062662
[No Abstract] [Full Text] [Related]
16. The Pathogenic TSH β-subunit Variant C105Vfs114X Causes a Modified Signaling Profile at TSHR.
Kalveram L; Kleinau G; Szymańska K; Scheerer P; Rivero-Müller A; Grüters-Kieslich A; Biebermann H
Int J Mol Sci; 2019 Nov; 20(22):. PubMed ID: 31703413
[TBL] [Abstract][Full Text] [Related]
17. Intracellular entrapment of wild-type TSH receptor by oligomerization with mutants linked to dominant TSH resistance.
Calebiro D; de Filippis T; Lucchi S; Covino C; Panigone S; Beck-Peccoz P; Dunlap D; Persani L
Hum Mol Genet; 2005 Oct; 14(20):2991-3002. PubMed ID: 16135555
[TBL] [Abstract][Full Text] [Related]
18. TSH Receptor Homodimerization in Regulation of cAMP Production in Human Thyrocytes
Boutin A; Krieger CC; Marcus-Samuels B; Klubo-Gwiezdzinska J; Neumann S; Gershengorn MC
Front Endocrinol (Lausanne); 2020; 11():276. PubMed ID: 32425890
[TBL] [Abstract][Full Text] [Related]
19. Studies on homologous desensitization of the thyrotropin receptor in 293 human embryonal kidney cells.
Nagayama Y; Chazenbalk GD; Takeshita A; Kimura H; Ashizawa K; Yokoyama N; Rapoport B; Nagataki S
Endocrinology; 1994 Sep; 135(3):1060-5. PubMed ID: 8070347
[TBL] [Abstract][Full Text] [Related]
20. Thyrotropin stimulation of the lutropin/choriogonadotropin receptor: different sites mediate agonist activity and high affinity binding.
Hidaka A; Ban T; Panesar NS; Minegishi T; Kohn LD; Tahara K
Thyroid; 1994; 4(4):447-57. PubMed ID: 7711510
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
