These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

101 related articles for article (PubMed ID: 21757343)

  • 21. Design, synthesis, and structure-activity relationships of novel bicyclic azole-amines as negative allosteric modulators of metabotropic glutamate receptor 5.
    Burdi DF; Hunt R; Fan L; Hu T; Wang J; Guo Z; Huang Z; Wu C; Hardy L; Detheux M; Orsini MA; Quinton MS; Lew R; Spear K
    J Med Chem; 2010 Oct; 53(19):7107-18. PubMed ID: 20809633
    [TBL] [Abstract][Full Text] [Related]  

  • 22. 2-Amino-5-aryl-pyridines as selective CB2 agonists: synthesis and investigation of structure-activity relationships.
    Gleave RJ; Beswick PJ; Brown AJ; Giblin GM; Haslam CP; Livermore D; Moses A; Nicholson NH; Page LW; Slingsby B; Swarbrick ME
    Bioorg Med Chem Lett; 2009 Dec; 19(23):6578-81. PubMed ID: 19864133
    [TBL] [Abstract][Full Text] [Related]  

  • 23. 5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity.
    Roppe JR; Wang B; Huang D; Tehrani L; Kamenecka T; Schweiger EJ; Anderson JJ; Brodkin J; Jiang X; Cramer M; Chung J; Reyes-Manalo G; Munoz B; Cosford ND
    Bioorg Med Chem Lett; 2004 Aug; 14(15):3993-6. PubMed ID: 15225713
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Synthesis and pharmacological characterization of novel druglike corticotropin-releasing factor 1 antagonists.
    Di Fabio R; St-Denis Y; Sabbatini FM; Andreotti D; Arban R; Bernasconi G; Braggio S; Blaney FE; Capelli AM; Castiglioni E; Di Modugno E; Donati D; Fazzolari E; Ratti E; Feriani A; Contini S; Gentile G; Ghirlanda D; Provera S; Marchioro C; Roberts KL; Mingardi A; Mattioli M; Nalin A; Pavone F; Spada S; Trist DG; Worby A
    J Med Chem; 2008 Dec; 51(23):7370-9. PubMed ID: 18989952
    [TBL] [Abstract][Full Text] [Related]  

  • 25. 3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists.
    Tehrani LR; Smith ND; Huang D; Poon SF; Roppe JR; Seiders TJ; Chapman DF; Chung J; Cramer M; Cosford ND
    Bioorg Med Chem Lett; 2005 Nov; 15(22):5061-4. PubMed ID: 16183275
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists.
    Wendt JA; Deeter SD; Bove SE; Knauer CS; Brooker RM; Augelli-Szafran CE; Schwarz RD; Kinsora JJ; Kilgore KS
    Bioorg Med Chem Lett; 2007 Oct; 17(19):5396-9. PubMed ID: 17723296
    [TBL] [Abstract][Full Text] [Related]  

  • 27. (S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors.
    Cosford ND; Bleicher L; Herbaut A; McCallum JS; Vernier JM; Dawson H; Whitten JP; Adams P; Chavez-Noriega L; Correa LD; Crona JH; Mahaffy LS; Menzaghi F; Rao TS; Reid R; Sacaan AI; Santori E; Stauderman KA; Whelan K; Lloyd GK; McDonald IA
    J Med Chem; 1996 Aug; 39(17):3235-7. PubMed ID: 8765504
    [No Abstract]   [Full Text] [Related]  

  • 28. Structure-activity relationships for the linker in a series of pyridinyl-alkynes that are antagonists of the metabotropic glutamate receptor 5 (mGluR5).
    Bach P; Nilsson K; Svensson T; Bauer U; Hammerland LG; Peterson A; Wållberg A; Osterlund K; Karis D; Boije M; Wensbo D
    Bioorg Med Chem Lett; 2006 Sep; 16(18):4788-91. PubMed ID: 16837196
    [TBL] [Abstract][Full Text] [Related]  

  • 29. mGlu1 and mGlu5 receptor antagonists lack anticonvulsant efficacy in rodent models of difficult-to-treat partial epilepsy.
    Löscher W; Dekundy A; Nagel J; Danysz W; Parsons CG; Potschka H
    Neuropharmacology; 2006 Jun; 50(8):1006-15. PubMed ID: 16563443
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Allosteric modulators of metabotropic glutamate receptors: lessons learnt from mGlu1, mGlu2 and mGlu5 potentiators and antagonists.
    Johnson MP; Nisenbaum ES; Large TH; Emkey R; Baez M; Kingston AE
    Biochem Soc Trans; 2004 Nov; 32(Pt 5):881-7. PubMed ID: 15494040
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists.
    Büttelmann B; Peters JU; Ceccarelli S; Kolczewski S; Vieira E; Prinssen EP; Spooren W; Schuler F; Huwyler J; Porter RH; Jaeschke G
    Bioorg Med Chem Lett; 2006 Apr; 16(7):1892-7. PubMed ID: 16439120
    [TBL] [Abstract][Full Text] [Related]  

  • 32. 2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors.
    Yan L; Budhu R; Huo P; Lynch CL; Hale JJ; Mills SG; Hajdu R; Keohane CA; Rosenbach MJ; Milligan JA; Shei GJ; Chrebet G; Bergstrom J; Card D; Mandala SM
    Bioorg Med Chem Lett; 2006 Jul; 16(13):3564-8. PubMed ID: 16621543
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Azetidinyl oxadiazoles as potent mGluR5 positive allosteric modulators.
    Packiarajan M; Ferreira CG; Hong SP; White AD; Chandrasena G; Pu X; Brodbeck RM; Robichaud AJ
    Bioorg Med Chem Lett; 2012 Oct; 22(20):6469-74. PubMed ID: 22975301
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).
    Varnes JG; Marcus AP; Mauger RC; Throner SR; Hoesch V; King MM; Wang X; Sygowski LA; Spear N; Gadient R; Brown DG; Campbell JB
    Bioorg Med Chem Lett; 2011 Mar; 21(5):1402-6. PubMed ID: 21295468
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Novel heterocyclic compounds as mGlu5 antagonists: WO2009015897.
    Doller D; Li G; Brodbeck RM; Thomsen C
    Expert Opin Ther Pat; 2010 Mar; 20(3):435-9. PubMed ID: 20180623
    [TBL] [Abstract][Full Text] [Related]  

  • 36. ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities.
    Liu F; Grauer S; Kelley C; Navarra R; Graf R; Zhang G; Atkinson PJ; Popiolek M; Wantuch C; Khawaja X; Smith D; Olsen M; Kouranova E; Lai M; Pruthi F; Pulicicchio C; Day M; Gilbert A; Pausch MH; Brandon NJ; Beyer CE; Comery TA; Logue S; Rosenzweig-Lipson S; Marquis KL
    J Pharmacol Exp Ther; 2008 Dec; 327(3):827-39. PubMed ID: 18753411
    [TBL] [Abstract][Full Text] [Related]  

  • 37. 4-aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators.
    Xiong H; Brugel TA; Balestra M; Brown DG; Brush KA; Hightower C; Hinkley L; Hoesch V; Kang J; Koether GM; McCauley JP; McLaren FM; Panko LM; Simpson TR; Smith RW; Woods JM; Brockel B; Chhajlani V; Gadient RA; Spear N; Sygowski LA; Zhang M; Arora J; Breysse N; Wilson JM; Isaac M; Slassi A; King MM
    Bioorg Med Chem Lett; 2010 Dec; 20(24):7381-4. PubMed ID: 21067920
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 2: 4-thiopyridyl acetophenones as non-tetrazole containing mGlu2 receptor potentiators.
    Pinkerton AB; Cube RV; Hutchinson JH; James JK; Gardner MF; Schaffhauser H; Rowe BA; Daggett LP; Vernier JM
    Bioorg Med Chem Lett; 2004 Dec; 14(23):5867-72. PubMed ID: 15501058
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Design and synthesis of a new class of selective integrin alpha5beta1 antagonists.
    Stragies R; Osterkamp F; Zischinsky G; Vossmeyer D; Kalkhof H; Reimer U; Zahn G
    J Med Chem; 2007 Aug; 50(16):3786-94. PubMed ID: 17616113
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity.
    Smith ND; Poon SF; Huang D; Green M; King C; Tehrani L; Roppe JR; Chung J; Chapman DP; Cramer M; Cosford ND
    Bioorg Med Chem Lett; 2004 Nov; 14(22):5481-4. PubMed ID: 15482908
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 6.