BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

1753 related articles for article (PubMed ID: 21760589)

  • 1. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.
    Possemato R; Marks KM; Shaul YD; Pacold ME; Kim D; Birsoy K; Sethumadhavan S; Woo HK; Jang HG; Jha AK; Chen WW; Barrett FG; Stransky N; Tsun ZY; Cowley GS; Barretina J; Kalaany NY; Hsu PP; Ottina K; Chan AM; Yuan B; Garraway LA; Root DE; Mino-Kenudson M; Brachtel EF; Driggers EM; Sabatini DM
    Nature; 2011 Aug; 476(7360):346-50. PubMed ID: 21760589
    [TBL] [Abstract][Full Text] [Related]  

  • 2. In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition.
    Rinaldi G; Pranzini E; Van Elsen J; Broekaert D; Funk CM; Planque M; Doglioni G; Altea-Manzano P; Rossi M; Geldhof V; Teoh ST; Ross C; Hunter KW; Lunt SY; Grünewald TGP; Fendt SM
    Mol Cell; 2021 Jan; 81(2):386-397.e7. PubMed ID: 33340488
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth.
    Chen J; Chung F; Yang G; Pu M; Gao H; Jiang W; Yin H; Capka V; Kasibhatla S; Laffitte B; Jaeger S; Pagliarini R; Chen Y; Zhou W
    Oncotarget; 2013 Dec; 4(12):2502-11. PubMed ID: 24318446
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression.
    Liu J; Zhang C; Wu H; Sun XX; Li Y; Huang S; Yue X; Lu SE; Shen Z; Su X; White E; Haffty BG; Hu W; Feng Z
    J Clin Invest; 2020 Jun; 130(6):3253-3269. PubMed ID: 32478681
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The NAD
    Murphy JP; Giacomantonio MA; Paulo JA; Everley RA; Kennedy BE; Pathak GP; Clements DR; Kim Y; Dai C; Sharif T; Gygi SP; Gujar S
    Cell Rep; 2018 Aug; 24(9):2381-2391.e5. PubMed ID: 30157431
    [TBL] [Abstract][Full Text] [Related]  

  • 6. p73 regulates serine biosynthesis in cancer.
    Amelio I; Markert EK; Rufini A; Antonov AV; Sayan BS; Tucci P; Agostini M; Mineo TC; Levine AJ; Melino G
    Oncogene; 2014 Oct; 33(42):5039-46. PubMed ID: 24186203
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression.
    Barnabas GD; Lee JS; Shami T; Harel M; Beck L; Selitrennik M; Jerby-Arnon L; Erez N; Ruppin E; Geiger T
    Cancer Res; 2021 Mar; 81(6):1443-1456. PubMed ID: 33500247
    [TBL] [Abstract][Full Text] [Related]  

  • 8. p53 Protein-mediated regulation of phosphoglycerate dehydrogenase (PHGDH) is crucial for the apoptotic response upon serine starvation.
    Ou Y; Wang SJ; Jiang L; Zheng B; Gu W
    J Biol Chem; 2015 Jan; 290(1):457-66. PubMed ID: 25404730
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Repression of phosphoglycerate dehydrogenase sensitizes triple-negative breast cancer to doxorubicin.
    Zhang X; Bai W
    Cancer Chemother Pharmacol; 2016 Sep; 78(3):655-9. PubMed ID: 27473325
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate.
    Fan J; Teng X; Liu L; Mattaini KR; Looper RE; Vander Heiden MG; Rabinowitz JD
    ACS Chem Biol; 2015 Feb; 10(2):510-6. PubMed ID: 25406093
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis.
    Pollari S; Käkönen SM; Edgren H; Wolf M; Kohonen P; Sara H; Guise T; Nees M; Kallioniemi O
    Breast Cancer Res Treat; 2011 Jan; 125(2):421-30. PubMed ID: 20352489
    [TBL] [Abstract][Full Text] [Related]  

  • 12. ASS1 inhibits triple-negative breast cancer by regulating PHGDH stability and de novo serine synthesis.
    Luo W; Zou Z; Nie Y; Luo J; Ming Z; Hu X; Luo T; Ouyang M; Liu M; Tang H; Xie Y; Peng K; Chen L; Zhou J; Luo Z
    Cell Death Dis; 2024 May; 15(5):319. PubMed ID: 38710705
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation.
    Wilson JL; Nägele T; Linke M; Demel F; Fritsch SD; Mayr HK; Cai Z; Katholnig K; Sun X; Fragner L; Miller A; Haschemi A; Popa A; Bergthaler A; Hengstschläger M; Weichhart T; Weckwerth W
    Cell Rep; 2020 Feb; 30(5):1542-1552.e7. PubMed ID: 32023468
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Acetylation Stabilizes Phosphoglycerate Dehydrogenase by Disrupting the Interaction of E3 Ligase RNF5 to Promote Breast Tumorigenesis.
    Wang C; Wan X; Yu T; Huang Z; Shen C; Qi Q; Xiang S; Chen X; Arbely E; Ling ZQ; Liu CY; Yu W
    Cell Rep; 2020 Aug; 32(6):108021. PubMed ID: 32783943
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E.
    Ma X; Li B; Liu J; Fu Y; Luo Y
    J Exp Clin Cancer Res; 2019 Feb; 38(1):66. PubMed ID: 30744688
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Prognostic significance of phosphoglycerate dehydrogenase in breast cancer.
    Chandrika M; Chua PJ; Muniasamy U; Huang RYJ; Thike AA; Ng CT; Tan PH; Yip GW; Bay BH
    Breast Cancer Res Treat; 2021 Apr; 186(3):655-665. PubMed ID: 33625616
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.
    Mullarky E; Lucki NC; Beheshti Zavareh R; Anglin JL; Gomes AP; Nicolay BN; Wong JC; Christen S; Takahashi H; Singh PK; Blenis J; Warren JD; Fendt SM; Asara JM; DeNicola GM; Lyssiotis CA; Lairson LL; Cantley LC
    Proc Natl Acad Sci U S A; 2016 Feb; 113(7):1778-83. PubMed ID: 26831078
    [TBL] [Abstract][Full Text] [Related]  

  • 18. High Phosphoglycerate Dehydrogenase Expression Induces Stemness and Aggressiveness in Thyroid Cancer.
    Jeon MJ; You MH; Han JM; Sim S; Yoo HJ; Lee WK; Kim TY; Song DE; Shong YK; Kim WG; Kim WB
    Thyroid; 2020 Nov; 30(11):1625-1638. PubMed ID: 32438862
    [No Abstract]   [Full Text] [Related]  

  • 19. The Role of D-3-Phosphoglycerate Dehydrogenase in Cancer.
    Zhao X; Fu J; Du J; Xu W
    Int J Biol Sci; 2020; 16(9):1495-1506. PubMed ID: 32226297
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
    Pacold ME; Brimacombe KR; Chan SH; Rohde JM; Lewis CA; Swier LJ; Possemato R; Chen WW; Sullivan LB; Fiske BP; Cho S; Freinkman E; Birsoy K; Abu-Remaileh M; Shaul YD; Liu CM; Zhou M; Koh MJ; Chung H; Davidson SM; Luengo A; Wang AQ; Xu X; Yasgar A; Liu L; Rai G; Westover KD; Vander Heiden MG; Shen M; Gray NS; Boxer MB; Sabatini DM
    Nat Chem Biol; 2016 Jun; 12(6):452-8. PubMed ID: 27110680
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 88.