These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

219 related articles for article (PubMed ID: 21764342)

  • 1. Insight into mechanism of small molecule inhibitors of the MDM2-p53 interaction: molecular dynamics simulation and free energy analysis.
    Chen J; Wang J; Xu B; Zhu W; Li G
    J Mol Graph Model; 2011 Sep; 30():46-53. PubMed ID: 21764342
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Molecular dynamics simulations studies and free energy analysis on inhibitors of MDM2-p53 interaction.
    Niu RJ; Zheng QC; Zhang JL; Zhang HX
    J Mol Graph Model; 2013 Nov; 46():132-9. PubMed ID: 24211465
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Computational studies of difference in binding modes of peptide and non-peptide inhibitors to MDM2/MDMX based on molecular dynamics simulations.
    Chen J; Zhang D; Zhang Y; Li G
    Int J Mol Sci; 2012; 13(2):2176-2195. PubMed ID: 22408446
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular modeling and molecular dynamics simulation studies on pyrrolopyrimidine-based α-helix mimetic as dual inhibitors of MDM2 and MDMX.
    Lu SY; Jiang YJ; Zou JW; Wu TX
    J Mol Graph Model; 2011 Sep; 30():167-78. PubMed ID: 21820342
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibiting mechanism of small molecule toward the p53-MDM2 interaction: A molecular dynamic exploration.
    Chen J; Wang J; Pang L; Zhu W
    Chem Biol Drug Des; 2018 Oct; 92(4):1763-1777. PubMed ID: 29877036
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Computational analysis of spiro-oxindole inhibitors of the MDM2-p53 interaction: insights and selection of novel inhibitors.
    Huang W; Cai L; Chen C; Xie X; Zhao Q; Zhao X; Zhou HY; Han B; Peng C
    J Biomol Struct Dyn; 2016; 34(2):341-51. PubMed ID: 25808617
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Probing Origin of Binding Difference of inhibitors to MDM2 and MDMX by Polarizable Molecular Dynamics Simulation and QM/MM-GBSA Calculation.
    Chen J; Wang J; Zhang Q; Chen K; Zhu W
    Sci Rep; 2015 Nov; 5():17421. PubMed ID: 26616018
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Insights into the Interaction Mechanisms of Peptide and Non-Peptide Inhibitors with MDM2 Using Gaussian-Accelerated Molecular Dynamics Simulations and Deep Learning.
    Yang W; Wang J; Zhao L; Chen J
    Molecules; 2024 Jul; 29(14):. PubMed ID: 39064955
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Characterizing the Free-Energy Landscape of MDM2 Protein-Ligand Interactions by Steered Molecular Dynamics Simulations.
    Hu G; Xu S; Wang J
    Chem Biol Drug Des; 2015 Dec; 86(6):1351-9. PubMed ID: 26032728
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Group-based QSAR and molecular dynamics mechanistic analysis revealing the mode of action of novel piperidinone derived protein-protein inhibitors of p53-MDM2.
    Goyal S; Grover S; Dhanjal JK; Tyagi C; Goyal M; Grover A
    J Mol Graph Model; 2014 Jun; 51():64-72. PubMed ID: 24858256
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of antipsychotic drug fluspirilene as a potential p53-MDM2 inhibitor: a combined computational and experimental study.
    Patil SP; Pacitti MF; Gilroy KS; Ruggiero JC; Griffin JD; Butera JJ; Notarfrancesco JM; Tran S; Stoddart JW
    J Comput Aided Mol Des; 2015 Feb; 29(2):155-63. PubMed ID: 25377899
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A computational analysis of the binding model of MDM2 with inhibitors.
    Hu G; Wang D; Liu X; Zhang Q
    J Comput Aided Mol Des; 2010 Aug; 24(8):687-97. PubMed ID: 20490618
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Hydrophobic Interactions Are a Key to MDM2 Inhibition by Polyphenols as Revealed by Molecular Dynamics Simulations and MM/PBSA Free Energy Calculations.
    Verma S; Grover S; Tyagi C; Goyal S; Jamal S; Singh A; Grover A
    PLoS One; 2016; 11(2):e0149014. PubMed ID: 26863418
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Quantum mechanical studies of residue-specific hydrophobic interactions in p53-MDM2 binding.
    Ding Y; Mei Y; Zhang JZ
    J Phys Chem B; 2008 Sep; 112(36):11396-401. PubMed ID: 18707164
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Co-operative intra-protein structural response due to protein-protein complexation revealed through thermodynamic quantification: study of MDM2-p53 binding.
    Samanta S; Mukherjee S
    J Comput Aided Mol Des; 2017 Oct; 31(10):891-903. PubMed ID: 28871352
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A computational analysis of binding modes and conformation changes of MDM2 induced by p53 and inhibitor bindings.
    Chen J; Wang J; Zhu W; Li G
    J Comput Aided Mol Des; 2013 Nov; 27(11):965-74. PubMed ID: 24264557
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Molecular investigation of the dual inhibition mechanism for targeted P53 regulator MDM2/MDMX inhibitors.
    Zhao X; Xiong D; Luo S; Duan L
    Phys Chem Chem Phys; 2022 Jul; 24(27):16799-16815. PubMed ID: 35775962
    [TBL] [Abstract][Full Text] [Related]  

  • 18. An integrated in silico screening strategy for identifying promising disruptors of p53-MDM2 interaction.
    Sirous H; Chemi G; Campiani G; Brogi S
    Comput Biol Chem; 2019 Dec; 83():107105. PubMed ID: 31473433
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery and optimization of triazine derivatives as ROCK1 inhibitors: molecular docking, molecular dynamics simulations and free energy calculations.
    Shen M; Zhou S; Li Y; Pan P; Zhang L; Hou T
    Mol Biosyst; 2013 Mar; 9(3):361-74. PubMed ID: 23340525
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Designing dual inhibitors of Mdm2/MdmX: Unexpected coupling of water with gatekeeper Y100/99.
    Lee XA; Verma C; Sim AYL
    Proteins; 2017 Aug; 85(8):1493-1506. PubMed ID: 28425639
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.