BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

295 related articles for article (PubMed ID: 21768539)

  • 1. Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²⁺release leading to catecholaminergic polymorphic ventricular tachycardia.
    Suetomi T; Yano M; Uchinoumi H; Fukuda M; Hino A; Ono M; Xu X; Tateishi H; Okuda S; Doi M; Kobayashi S; Ikeda Y; Yamamoto T; Ikemoto N; Matsuzaki M
    Circulation; 2011 Aug; 124(6):682-94. PubMed ID: 21768539
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor.
    Uchinoumi H; Yano M; Suetomi T; Ono M; Xu X; Tateishi H; Oda T; Okuda S; Doi M; Kobayashi S; Yamamoto T; Ikeda Y; Ohkusa T; Ikemoto N; Matsuzaki M
    Circ Res; 2010 Apr; 106(8):1413-24. PubMed ID: 20224043
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Dantrolene, a therapeutic agent for malignant hyperthermia, inhibits catecholaminergic polymorphic ventricular tachycardia in a RyR2(R2474S/+) knock-in mouse model.
    Kobayashi S; Yano M; Uchinoumi H; Suetomi T; Susa T; Ono M; Xu X; Tateishi H; Oda T; Okuda S; Doi M; Yamamoto T; Matsuzaki M
    Circ J; 2010 Nov; 74(12):2579-84. PubMed ID: 20944434
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mutation-linked, excessively tight interaction between the calmodulin binding domain and the C-terminal domain of the cardiac ryanodine receptor as a novel cause of catecholaminergic polymorphic ventricular tachycardia.
    Nishimura S; Yamamoto T; Nakamura Y; Kohno M; Hamada Y; Sufu Y; Fukui G; Nanno T; Ishiguchi H; Kato T; Xu X; Ono M; Oda T; Okuda S; Kobayashi S; Yano M
    Heart Rhythm; 2018 Jun; 15(6):905-914. PubMed ID: 29427818
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction.
    Xu X; Yano M; Uchinoumi H; Hino A; Suetomi T; Ono M; Tateishi H; Oda T; Okuda S; Doi M; Kobayashi S; Yamamoto T; Ikeda Y; Ikemoto N; Matsuzaki M
    Biochem Biophys Res Commun; 2010 Apr; 394(3):660-6. PubMed ID: 20226167
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor.
    Kobayashi S; Yano M; Suetomi T; Ono M; Tateishi H; Mochizuki M; Xu X; Uchinoumi H; Okuda S; Yamamoto T; Koseki N; Kyushiki H; Ikemoto N; Matsuzaki M
    J Am Coll Cardiol; 2009 May; 53(21):1993-2005. PubMed ID: 19460614
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts.
    Tateishi H; Yano M; Mochizuki M; Suetomi T; Ono M; Xu X; Uchinoumi H; Okuda S; Oda T; Kobayashi S; Yamamoto T; Ikeda Y; Ohkusa T; Ikemoto N; Matsuzaki M
    Cardiovasc Res; 2009 Feb; 81(3):536-45. PubMed ID: 18996969
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Ryanodine receptor-bound calmodulin is essential to protect against catecholaminergic polymorphic ventricular tachycardia.
    Nakamura Y; Yamamoto T; Kobayashi S; Tamitani M; Hamada Y; Fukui G; Xu X; Nishimura S; Kato T; Uchinoumi H; Oda T; Okuda S; Yano M
    JCI Insight; 2019 Jun; 4(11):. PubMed ID: 31167968
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Z16b, a natural compound from Ganoderma cochlear is a novel RyR2 stabilizer preventing catecholaminergic polymorphic ventricular tachycardia.
    Wan JF; Wang G; Qin FY; Huang DL; Wang Y; Su AL; Zhang HP; Liu Y; Zeng SY; Wei CL; Cheng YX; Liu J
    Acta Pharmacol Sin; 2022 Sep; 43(9):2340-2350. PubMed ID: 35190699
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Paradoxical effect of increased diastolic Ca(2+) release and decreased sinoatrial node activity in a mouse model of catecholaminergic polymorphic ventricular tachycardia.
    Neco P; Torrente AG; Mesirca P; Zorio E; Liu N; Priori SG; Napolitano C; Richard S; Benitah JP; Mangoni ME; Gómez AM
    Circulation; 2012 Jul; 126(4):392-401. PubMed ID: 22711277
    [TBL] [Abstract][Full Text] [Related]  

  • 11. In situ confocal imaging in intact heart reveals stress-induced Ca(2+) release variability in a murine catecholaminergic polymorphic ventricular tachycardia model of type 2 ryanodine receptor(R4496C+/-) mutation.
    Chen B; Guo A; Gao Z; Wei S; Xie YP; Chen SR; Anderson ME; Song LS
    Circ Arrhythm Electrophysiol; 2012 Aug; 5(4):841-9. PubMed ID: 22722659
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Calcium leak through ryanodine receptors leads to atrial fibrillation in 3 mouse models of catecholaminergic polymorphic ventricular tachycardia.
    Shan J; Xie W; Betzenhauser M; Reiken S; Chen BX; Wronska A; Marks AR
    Circ Res; 2012 Aug; 111(6):708-17. PubMed ID: 22828895
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Increased Ca2+ sensitivity of the ryanodine receptor mutant RyR2R4496C underlies catecholaminergic polymorphic ventricular tachycardia.
    Fernández-Velasco M; Rueda A; Rizzi N; Benitah JP; Colombi B; Napolitano C; Priori SG; Richard S; Gómez AM
    Circ Res; 2009 Jan; 104(2):201-9, 12p following 209. PubMed ID: 19096022
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Pathogenic mechanism of a catecholaminergic polymorphic ventricular tachycardia causing-mutation in cardiac calcium release channel RyR2.
    Xiong J; Liu X; Gong Y; Zhang P; Qiang S; Zhao Q; Guo R; Qian Y; Wang L; Zhu L; Wang R; Hao Z; Wen H; Zhang J; Tang K; Zang WF; Yuchi Z; Chen H; Chen SRW; Zheng W; Wang SQ; Xu YW; Liu Z
    J Mol Cell Cardiol; 2018 Apr; 117():26-35. PubMed ID: 29477366
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A novel ryanodine receptor mutation linked to sudden death increases sensitivity to cytosolic calcium.
    Meli AC; Refaat MM; Dura M; Reiken S; Wronska A; Wojciak J; Carroll J; Scheinman MM; Marks AR
    Circ Res; 2011 Jul; 109(3):281-90. PubMed ID: 21659649
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release.
    Manotheepan R; Danielsen TK; Sadredini M; Anderson ME; Carlson CR; Lehnart SE; Sjaastad I; Stokke MK
    Cardiovasc Res; 2016 Aug; 111(3):295-306. PubMed ID: 27161030
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse model.
    Liu N; Colombi B; Memmi M; Zissimopoulos S; Rizzi N; Negri S; Imbriani M; Napolitano C; Lai FA; Priori SG
    Circ Res; 2006 Aug; 99(3):292-8. PubMed ID: 16825580
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Dantrolene rescues aberrant N-terminus intersubunit interactions in mutant pro-arrhythmic cardiac ryanodine receptors.
    Seidel M; Thomas NL; Williams AJ; Lai FA; Zissimopoulos S
    Cardiovasc Res; 2015 Jan; 105(1):118-28. PubMed ID: 25411383
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts.
    Yamamoto T; Yano M; Xu X; Uchinoumi H; Tateishi H; Mochizuki M; Oda T; Kobayashi S; Ikemoto N; Matsuzaki M
    Circulation; 2008 Feb; 117(6):762-72. PubMed ID: 18227387
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Heterogeneity of ryanodine receptor dysfunction in a mouse model of catecholaminergic polymorphic ventricular tachycardia.
    Loaiza R; Benkusky NA; Powers PP; Hacker T; Noujaim S; Ackerman MJ; Jalife J; Valdivia HH
    Circ Res; 2013 Jan; 112(2):298-308. PubMed ID: 23152493
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.