These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

201 related articles for article (PubMed ID: 21783369)

  • 1. Synthesis and topoisomerase I inhibitory activity of a novel diazaindeno[2,1-b]phenanthrene analogue of Lamellarin D.
    Cananzi S; Merlini L; Artali R; Beretta GL; Zaffaroni N; Dallavalle S
    Bioorg Med Chem; 2011 Aug; 19(16):4971-84. PubMed ID: 21783369
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Topoisomerase I-mediated DNA cleavage as a guide to the development of antitumor agents derived from the marine alkaloid lamellarin D: triester derivatives incorporating amino acid residues.
    Tardy C; Facompré M; Laine W; Baldeyrou B; García-Gravalos D; Francesch A; Mateo C; Pastor A; Jiménez JA; Manzanares I; Cuevas C; Bailly C
    Bioorg Med Chem; 2004 Apr; 12(7):1697-712. PubMed ID: 15028262
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design and total synthesis of Mannich derivatives of marine natural product lamellarin D as cytotoxic agents.
    Shen L; Xie N; Yang B; Hu Y; Zhang Y
    Eur J Med Chem; 2014 Oct; 85():807-17. PubMed ID: 25189362
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis, and biological evaluation of novel benzo[6,7]indolo[3,4-c]isoquinolines as anticancer agents with topoisomerase I inhibition.
    Sakai K; Soshima T; Hirose Y; Ishibashi F; Hirao S
    Bioorg Med Chem Lett; 2024 May; 104():129710. PubMed ID: 38518997
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and biological evaluation of a D-ring-contracted analogue of lamellarin D.
    Colligs V; Hansen SP; Imbri D; Seo EJ; Kadioglu O; Efferth T; Opatz T
    Bioorg Med Chem; 2017 Nov; 25(22):6137-6148. PubMed ID: 28233677
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design, Synthesis and Structure-Activity Relationship Studies of Glycosylated Derivatives of Marine Natural Product Lamellarin D.
    Zheng L; Gao T; Ge Z; Ma Z; Xu J; Ding W; Shen L
    Eur J Med Chem; 2021 Mar; 214():113226. PubMed ID: 33582387
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Lamellarin D: a novel potent inhibitor of topoisomerase I.
    Facompré M; Tardy C; Bal-Mahieu C; Colson P; Perez C; Manzanares I; Cuevas C; Bailly C
    Cancer Res; 2003 Nov; 63(21):7392-9. PubMed ID: 14612538
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and structure-activity relationship study of potent cytotoxic analogues of the marine alkaloid Lamellarin D.
    Pla D; Marchal A; Olsen CA; Francesch A; Cuevas C; Albericio F; Alvarez M
    J Med Chem; 2006 Jun; 49(11):3257-68. PubMed ID: 16722644
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: a novel DYRK1A inhibitor class.
    Neagoie C; Vedrenne E; Buron F; Mérour JY; Rosca S; Bourg S; Lozach O; Meijer L; Baldeyrou B; Lansiaux A; Routier S
    Eur J Med Chem; 2012 Mar; 49():379-96. PubMed ID: 22305342
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Molecular determinants of topoisomerase I poisoning by lamellarins: comparison with camptothecin and structure-activity relationships.
    Marco E; Laine W; Tardy C; Lansiaux A; Iwao M; Ishibashi F; Bailly C; Gago F
    J Med Chem; 2005 Jun; 48(11):3796-807. PubMed ID: 15916431
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis of benzo[3,4]azepino[1,2-b]isoquinolin-9-ones from 3-arylisoquinolines via ring closing metathesis and evaluation of topoisomerase I inhibitory activity, cytotoxicity and docking study.
    Van HT; Khadka DB; Yang SH; Le TN; Cho SH; Zhao C; Lee IS; Kwon Y; Lee KT; Kim YC; Cho WJ
    Bioorg Med Chem; 2011 Sep; 19(18):5311-20. PubMed ID: 21873069
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Lamellarin D bioconjugates II: Synthesis and cellular internalization of dendrimer and nuclear location signal derivatives.
    Pla D; Martí M; Farrera-Sinfreu J; Pulido D; Francesch A; Calvo P; Cuevas C; Royo M; Aligué R; Albericio F; Alvarez M
    Bioconjug Chem; 2009 Jun; 20(6):1112-21. PubMed ID: 19472996
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis and systematic evaluation of cytotoxic 3-heteroarylisoquinolinamines as topoisomerases inhibitors.
    My Van HT; Woo H; Jeong HM; Khadka DB; Yang SH; Zhao C; Jin Y; Lee ES; Youl Lee K; Kwon Y; Cho WJ
    Eur J Med Chem; 2014 Jul; 82():181-94. PubMed ID: 24904965
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Anticancer properties of lamellarins.
    Bailly C
    Mar Drugs; 2015 Feb; 13(3):1105-23. PubMed ID: 25706633
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and biological evaluations of novel indenoisoquinolines as topoisomerase I inhibitors.
    Zhang X; Wang R; Zhao L; Lu N; Wang J; You Q; Li Z; Guo Q
    Bioorg Med Chem Lett; 2012 Jan; 22(2):1276-81. PubMed ID: 22079759
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Lamellarin D bioconjugates I: Synthesis and cellular internalization of PEG-derivatives.
    Pla D; Francesch A; Calvo P; Cuevas C; Aligué R; Albericio F; Alvarez M
    Bioconjug Chem; 2009 Jun; 20(6):1100-11. PubMed ID: 19472995
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors.
    Seol Y; Zhang H; Agama K; Lorence N; Pommier Y; Neuman KC
    Mol Cancer Ther; 2015 Nov; 14(11):2552-9. PubMed ID: 26351326
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design and synthesis of lamellarin D analogues targeting topoisomerase I.
    Ohta T; Fukuda T; Ishibashi F; Iwao M
    J Org Chem; 2009 Nov; 74(21):8143-53. PubMed ID: 19791738
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Lamellarin D: a novel pro-apoptotic agent from marine origin insensitive to P-glycoprotein-mediated drug efflux.
    Vanhuyse M; Kluza J; Tardy C; Otero G; Cuevas C; Bailly C; Lansiaux A
    Cancer Lett; 2005 Apr; 221(2):165-75. PubMed ID: 15808402
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.
    Fukuda T; Nanjo Y; Fujimoto M; Yoshida K; Natsui Y; Ishibashi F; Okazaki F; To H; Iwao M
    Bioorg Med Chem; 2019 Jan; 27(2):265-277. PubMed ID: 30553626
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.