233 related articles for article (PubMed ID: 21784771)
1. L-arginine is essential for pancreatic β-cell functional integrity, metabolism and defense from inflammatory challenge.
Krause MS; McClenaghan NH; Flatt PR; de Bittencourt PI; Murphy C; Newsholme P
J Endocrinol; 2011 Oct; 211(1):87-97. PubMed ID: 21784771
[TBL] [Abstract][Full Text] [Related]
2. Physiological concentrations of interleukin-6 directly promote insulin secretion, signal transduction, nitric oxide release, and redox status in a clonal pancreatic β-cell line and mouse islets.
da Silva Krause M; Bittencourt A; Homem de Bittencourt PI; McClenaghan NH; Flatt PR; Murphy C; Newsholme P
J Endocrinol; 2012 Sep; 214(3):301-11. PubMed ID: 22761278
[TBL] [Abstract][Full Text] [Related]
3. Effects of pharmacological inhibition of NADPH oxidase or iNOS on pro-inflammatory cytokine, palmitic acid or H2O2-induced mouse islet or clonal pancreatic β-cell dysfunction.
Michalska M; Wolf G; Walther R; Newsholme P
Biosci Rep; 2010 Dec; 30(6):445-53. PubMed ID: 20178457
[TBL] [Abstract][Full Text] [Related]
4. L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic beta-cell line and protects from pro-inflammatory cytokine-induced apoptosis.
Cunningham GA; McClenaghan NH; Flatt PR; Newsholme P
Clin Sci (Lond); 2005 Nov; 109(5):447-55. PubMed ID: 16045439
[TBL] [Abstract][Full Text] [Related]
5. Alanyl-glutamine improves pancreatic β-cell function following ex vivo inflammatory challenge.
Cruzat VF; Keane KN; Scheinpflug AL; Cordeiro R; Soares MJ; Newsholme P
J Endocrinol; 2015 Mar; 224(3):261-71. PubMed ID: 25550445
[TBL] [Abstract][Full Text] [Related]
6. Pro-inflammatory cytokines increase glucose, alanine and triacylglycerol utilization but inhibit insulin secretion in a clonal pancreatic beta-cell line.
Kiely A; McClenaghan NH; Flatt PR; Newsholme P
J Endocrinol; 2007 Oct; 195(1):113-23. PubMed ID: 17911403
[TBL] [Abstract][Full Text] [Related]
7. Cytokine-induced inhibition of insulin release from mouse pancreatic beta-cells deficient in inducible nitric oxide synthase.
Andersson AK; Flodström M; Sandler S
Biochem Biophys Res Commun; 2001 Feb; 281(2):396-403. PubMed ID: 11181061
[TBL] [Abstract][Full Text] [Related]
8. Evidence for a sustained increase in clonal beta-cell basal intracellular Ca2+ levels after incubation in the presence of newly diagnosed Type-1 diabetic patient sera. Possible role in serum-induced inhibition of insulin secretion.
Conroy SJ; Green I; Dixon G; Byrne PM; Nolan J; Abdel-Wahab YH; McClenaghan N; Flatt PR; Newsholme P
J Endocrinol; 2002 Apr; 173(1):53-62. PubMed ID: 11927384
[TBL] [Abstract][Full Text] [Related]
9. Mechanisms of amino acid-induced insulin secretion from the glucose-responsive BRIN-BD11 pancreatic B-cell line.
McClenaghan NH; Barnett CR; O'Harte FP; Flatt PR
J Endocrinol; 1996 Dec; 151(3):349-57. PubMed ID: 8994380
[TBL] [Abstract][Full Text] [Related]
10. Osteopontin protects the islets and beta-cells from interleukin-1 beta-mediated cytotoxicity through negative feedback regulation of nitric oxide.
Arafat HA; Katakam AK; Chipitsyna G; Gong Q; Vancha AR; Gabbeta J; Dafoe DC
Endocrinology; 2007 Feb; 148(2):575-84. PubMed ID: 17110428
[TBL] [Abstract][Full Text] [Related]
11. Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line.
Morgan D; Oliveira-Emilio HR; Keane D; Hirata AE; Santos da Rocha M; Bordin S; Curi R; Newsholme P; Carpinelli AR
Diabetologia; 2007 Feb; 50(2):359-69. PubMed ID: 17151863
[TBL] [Abstract][Full Text] [Related]
12. Chronic palmitate exposure inhibits AMPKalpha and decreases glucose-stimulated insulin secretion from beta-cells: modulation by fenofibrate.
Sun Y; Ren M; Gao GQ; Gong B; Xin W; Guo H; Zhang XJ; Gao L; Zhao JJ
Acta Pharmacol Sin; 2008 Apr; 29(4):443-50. PubMed ID: 18358090
[TBL] [Abstract][Full Text] [Related]
13. Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic β-cell dysfunction and death in vitro.
Krause M; Keane K; Rodrigues-Krause J; Crognale D; Egan B; De Vito G; Murphy C; Newsholme P
Clin Sci (Lond); 2014 May; 126(10):739-52. PubMed ID: 24325467
[TBL] [Abstract][Full Text] [Related]
14. A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line: metabolism of L-alanine is important to the regulation of insulin secretion.
Brennan L; Shine A; Hewage C; Malthouse JP; Brindle KM; McClenaghan N; Flatt PR; Newsholme P
Diabetes; 2002 Jun; 51(6):1714-21. PubMed ID: 12031957
[TBL] [Abstract][Full Text] [Related]
15. Elevated levels of branched-chain amino acids have little effect on pancreatic islet cells, but L-arginine impairs function through activation of the endoplasmic reticulum stress response.
Mullooly N; Vernon W; Smith DM; Newsholme P
Exp Physiol; 2014 Mar; 99(3):538-51. PubMed ID: 24334335
[TBL] [Abstract][Full Text] [Related]
16. L-arginine stimulates cyclic guanosine 3',5'-monophosphate formation in rat islets of Langerhans and RINm5F insulinoma cells: evidence for L-arginine:nitric oxide synthase.
Laychock SG; Modica ME; Cavanaugh CT
Endocrinology; 1991 Dec; 129(6):3043-52. PubMed ID: 1683279
[TBL] [Abstract][Full Text] [Related]
17. Tissue factor/factor VIIa signalling promotes cytokine-induced beta cell death and impairs glucose-stimulated insulin secretion from human pancreatic islets.
Edén D; Siegbahn A; Mokhtari D
Diabetologia; 2015 Nov; 58(11):2563-72. PubMed ID: 26271343
[TBL] [Abstract][Full Text] [Related]
18. Flavonoids protect against cytokine-induced pancreatic beta-cell damage through suppression of nuclear factor kappaB activation.
Kim EK; Kwon KB; Song MY; Han MJ; Lee JH; Lee YR; Lee JH; Ryu DG; Park BH; Park JW
Pancreas; 2007 Nov; 35(4):e1-9. PubMed ID: 18090225
[TBL] [Abstract][Full Text] [Related]
19. Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling.
Granata R; Settanni F; Biancone L; Trovato L; Nano R; Bertuzzi F; Destefanis S; Annunziata M; Martinetti M; Catapano F; Ghè C; Isgaard J; Papotti M; Ghigo E; Muccioli G
Endocrinology; 2007 Feb; 148(2):512-29. PubMed ID: 17068144
[TBL] [Abstract][Full Text] [Related]
20. Differential sensitivity to beta-cell secretagogues in cultured rat pancreatic islets exposed to human interleukin-1 beta.
Eizirik DL; Sandler S; Hallberg A; Bendtzen K; Sener A; Malaisse WJ
Endocrinology; 1989 Aug; 125(2):752-9. PubMed ID: 2666106
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]