BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

448 related articles for article (PubMed ID: 21784859)

  • 21. Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion.
    Martin TD; Chen XW; Kaplan RE; Saltiel AR; Walker CL; Reiner DJ; Der CJ
    Mol Cell; 2014 Jan; 53(2):209-20. PubMed ID: 24389102
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Phospholipase D1 is an effector of Rheb in the mTOR pathway.
    Sun Y; Fang Y; Yoon MS; Zhang C; Roccio M; Zwartkruis FJ; Armstrong M; Brown HA; Chen J
    Proc Natl Acad Sci U S A; 2008 Jun; 105(24):8286-91. PubMed ID: 18550814
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.
    Li Y; Inoki K; Guan KL
    Mol Cell Biol; 2004 Sep; 24(18):7965-75. PubMed ID: 15340059
    [TBL] [Abstract][Full Text] [Related]  

  • 24. The TSC1-TSC2 complex is required for proper activation of mTOR complex 2.
    Huang J; Dibble CC; Matsuzaki M; Manning BD
    Mol Cell Biol; 2008 Jun; 28(12):4104-15. PubMed ID: 18411301
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9.
    Jung J; Genau HM; Behrends C
    Mol Cell Biol; 2015 Jul; 35(14):2479-94. PubMed ID: 25963655
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways.
    Gau CL; Kato-Stankiewicz J; Jiang C; Miyamoto S; Guo L; Tamanoi F
    Mol Cancer Ther; 2005 Jun; 4(6):918-26. PubMed ID: 15956249
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.
    Misra UK; Pizzo SV
    PLoS One; 2012; 7(12):e51735. PubMed ID: 23272152
    [TBL] [Abstract][Full Text] [Related]  

  • 28. The late endosome is essential for mTORC1 signaling.
    Flinn RJ; Yan Y; Goswami S; Parker PJ; Backer JM
    Mol Biol Cell; 2010 Mar; 21(5):833-41. PubMed ID: 20053679
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes.
    Ögmundsdóttir MH; Heublein S; Kazi S; Reynolds B; Visvalingam SM; Shaw MK; Goberdhan DC
    PLoS One; 2012; 7(5):e36616. PubMed ID: 22574197
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein.
    Sato T; Nakashima A; Guo L; Tamanoi F
    J Biol Chem; 2009 May; 284(19):12783-91. PubMed ID: 19299511
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Mammalian target of rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts.
    Groenewoud MJ; Goorden SM; Kassies J; Pellis-van Berkel W; Lamb RF; Elgersma Y; Zwartkruis FJ
    PLoS One; 2013; 8(11):e81649. PubMed ID: 24303063
    [TBL] [Abstract][Full Text] [Related]  

  • 32. The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses.
    Smith EM; Finn SG; Tee AR; Browne GJ; Proud CG
    J Biol Chem; 2005 May; 280(19):18717-27. PubMed ID: 15772076
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Cyclic AMP controls mTOR through regulation of the dynamic interaction between Rheb and phosphodiesterase 4D.
    Kim HW; Ha SH; Lee MN; Huston E; Kim DH; Jang SK; Suh PG; Houslay MD; Ryu SH
    Mol Cell Biol; 2010 Nov; 30(22):5406-20. PubMed ID: 20837708
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Rheb/mTORC1 signaling promotes kidney fibroblast activation and fibrosis.
    Jiang L; Xu L; Mao J; Li J; Fang L; Zhou Y; Liu W; He W; Zhao AZ; Yang J; Dai C
    J Am Soc Nephrol; 2013 Jun; 24(7):1114-26. PubMed ID: 23661807
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation.
    Foster KG; Acosta-Jaquez HA; Romeo Y; Ekim B; Soliman GA; Carriere A; Roux PP; Ballif BA; Fingar DC
    J Biol Chem; 2010 Jan; 285(1):80-94. PubMed ID: 19864431
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1.
    Zheng M; Wang YH; Wu XN; Wu SQ; Lu BJ; Dong MQ; Zhang H; Sun P; Lin SC; Guan KL; Han J
    Nat Cell Biol; 2011 Mar; 13(3):263-72. PubMed ID: 21336308
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Amino acid regulation of TOR complex 1.
    Avruch J; Long X; Ortiz-Vega S; Rapley J; Papageorgiou A; Dai N
    Am J Physiol Endocrinol Metab; 2009 Apr; 296(4):E592-602. PubMed ID: 18765678
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
    Sancak Y; Bar-Peled L; Zoncu R; Markhard AL; Nada S; Sabatini DM
    Cell; 2010 Apr; 141(2):290-303. PubMed ID: 20381137
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.
    Oshiro N; Rapley J; Avruch J
    J Biol Chem; 2014 Jan; 289(5):2658-74. PubMed ID: 24337580
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1.
    Schweitzer LD; Comb WC; Bar-Peled L; Sabatini DM
    Cell Rep; 2015 Sep; 12(9):1445-55. PubMed ID: 26299971
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 23.