BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

459 related articles for article (PubMed ID: 21784859)

  • 61. Characterization of the Rheb-mTOR signaling pathway in mammalian cells: constitutive active mutants of Rheb and mTOR.
    Sato T; Umetsu A; Tamanoi F
    Methods Enzymol; 2008; 438():307-20. PubMed ID: 18413257
    [TBL] [Abstract][Full Text] [Related]  

  • 62. The mammalian target of rapamycin complex 1 regulates leptin biosynthesis in adipocytes at the level of translation: the role of the 5'-untranslated region in the expression of leptin messenger ribonucleic acid.
    Chakrabarti P; Anno T; Manning BD; Luo Z; Kandror KV
    Mol Endocrinol; 2008 Oct; 22(10):2260-7. PubMed ID: 18653778
    [TBL] [Abstract][Full Text] [Related]  

  • 63. Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.
    Peng M; Yin N; Li MO
    Cell; 2014 Sep; 159(1):122-133. PubMed ID: 25259925
    [TBL] [Abstract][Full Text] [Related]  

  • 64. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.
    Garami A; Zwartkruis FJ; Nobukuni T; Joaquin M; Roccio M; Stocker H; Kozma SC; Hafen E; Bos JL; Thomas G
    Mol Cell; 2003 Jun; 11(6):1457-66. PubMed ID: 12820960
    [TBL] [Abstract][Full Text] [Related]  

  • 65. Activation of AMPK/TSC2/PLD by alcohol regulates mTORC1 and mTORC2 assembly in C2C12 myocytes.
    Hong-Brown LQ; Brown CR; Navaratnarajah M; Lang CH
    Alcohol Clin Exp Res; 2013 Nov; 37(11):1849-61. PubMed ID: 23895284
    [TBL] [Abstract][Full Text] [Related]  

  • 66. Lysosomal accumulation of mTOR is enhanced by rapamycin.
    Ohsaki Y; Suzuki M; Shinohara Y; Fujimoto T
    Histochem Cell Biol; 2010 Dec; 134(6):537-44. PubMed ID: 21063721
    [TBL] [Abstract][Full Text] [Related]  

  • 67. Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.
    Kim SG; Hoffman GR; Poulogiannis G; Buel GR; Jang YJ; Lee KW; Kim BY; Erikson RL; Cantley LC; Choo AY; Blenis J
    Mol Cell; 2013 Jan; 49(1):172-85. PubMed ID: 23142078
    [TBL] [Abstract][Full Text] [Related]  

  • 68. Rheb regulates nuclear mTORC1 activity independent of farnesylation.
    Zhong Y; Zhou X; Guan KL; Zhang J
    Cell Chem Biol; 2022 Jun; 29(6):1037-1045.e4. PubMed ID: 35294906
    [TBL] [Abstract][Full Text] [Related]  

  • 69. The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1.
    Oshiro N; Takahashi R; Yoshino K; Tanimura K; Nakashima A; Eguchi S; Miyamoto T; Hara K; Takehana K; Avruch J; Kikkawa U; Yonezawa K
    J Biol Chem; 2007 Jul; 282(28):20329-39. PubMed ID: 17517883
    [TBL] [Abstract][Full Text] [Related]  

  • 70. Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease.
    Pryor WM; Biagioli M; Shahani N; Swarnkar S; Huang WC; Page DT; MacDonald ME; Subramaniam S
    Sci Signal; 2014 Oct; 7(349):ra103. PubMed ID: 25351248
    [TBL] [Abstract][Full Text] [Related]  

  • 71. Ras homolog enriched in brain (Rheb) enhances apoptotic signaling.
    Karassek S; Berghaus C; Schwarten M; Goemans CG; Ohse N; Kock G; Jockers K; Neumann S; Gottfried S; Herrmann C; Heumann R; Stoll R
    J Biol Chem; 2010 Oct; 285(44):33979-91. PubMed ID: 20685651
    [TBL] [Abstract][Full Text] [Related]  

  • 72. TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1.
    Plescher M; Teleman AA; Demetriades C
    Sci Rep; 2015 Sep; 5():13828. PubMed ID: 26345496
    [TBL] [Abstract][Full Text] [Related]  

  • 73. Analysis of gene expression array in TSC2-deficient AML cells reveals IRF7 as a pivotal factor in the Rheb/mTOR pathway.
    Makovski V; Jacob-Hirsch J; Gefen-Dor C; Shai B; Ehrlich M; Rechavi G; Kloog Y
    Cell Death Dis; 2014 Dec; 5(12):e1557. PubMed ID: 25476905
    [TBL] [Abstract][Full Text] [Related]  

  • 74. Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity.
    Sato T; Akasu H; Shimono W; Matsu C; Fujiwara Y; Shibagaki Y; Heard JJ; Tamanoi F; Hattori S
    J Biol Chem; 2015 Jan; 290(2):1096-105. PubMed ID: 25422319
    [TBL] [Abstract][Full Text] [Related]  

  • 75. A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS.
    Zhang J; Kim J; Alexander A; Cai S; Tripathi DN; Dere R; Tee AR; Tait-Mulder J; Di Nardo A; Han JM; Kwiatkowski E; Dunlop EA; Dodd KM; Folkerth RD; Faust PL; Kastan MB; Sahin M; Walker CL
    Nat Cell Biol; 2013 Oct; 15(10):1186-96. PubMed ID: 23955302
    [TBL] [Abstract][Full Text] [Related]  

  • 76. Tsc2-Rheb signaling regulates EphA-mediated axon guidance.
    Nie D; Di Nardo A; Han JM; Baharanyi H; Kramvis I; Huynh T; Dabora S; Codeluppi S; Pandolfi PP; Pasquale EB; Sahin M
    Nat Neurosci; 2010 Feb; 13(2):163-72. PubMed ID: 20062052
    [TBL] [Abstract][Full Text] [Related]  

  • 77. Rhebbing up mTOR: new insights on TSC1 and TSC2, and the pathogenesis of tuberous sclerosis.
    Kwiatkowski DJ
    Cancer Biol Ther; 2003; 2(5):471-6. PubMed ID: 14614311
    [TBL] [Abstract][Full Text] [Related]  

  • 78. Key mediators of intracellular amino acids signaling to mTORC1 activation.
    Duan Y; Li F; Tan K; Liu H; Li Y; Liu Y; Kong X; Tang Y; Wu G; Yin Y
    Amino Acids; 2015 May; 47(5):857-67. PubMed ID: 25701492
    [TBL] [Abstract][Full Text] [Related]  

  • 79. Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors.
    Huang J; Wu S; Wu CL; Manning BD
    Cancer Res; 2009 Aug; 69(15):6107-14. PubMed ID: 19602587
    [TBL] [Abstract][Full Text] [Related]  

  • 80. Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1.
    Di Nardo A; Wertz MH; Kwiatkowski E; Tsai PT; Leech JD; Greene-Colozzi E; Goto J; Dilsiz P; Talos DM; Clish CB; Kwiatkowski DJ; Sahin M
    Hum Mol Genet; 2014 Jul; 23(14):3865-74. PubMed ID: 24599401
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 23.