217 related articles for article (PubMed ID: 21789769)
1. Aggregation in protein-based biotherapeutics: computational studies and tools to identify aggregation-prone regions.
Agrawal NJ; Kumar S; Wang X; Helk B; Singh SK; Trout BL
J Pharm Sci; 2011 Dec; 100(12):5081-95. PubMed ID: 21789769
[TBL] [Abstract][Full Text] [Related]
2. Computational methods to predict therapeutic protein aggregation.
Buck PM; Kumar S; Wang X; Agrawal NJ; Trout BL; Singh SK
Methods Mol Biol; 2012; 899():425-51. PubMed ID: 22735968
[TBL] [Abstract][Full Text] [Related]
3. Coupling of aggregation and immunogenicity in biotherapeutics: T- and B-cell immune epitopes may contain aggregation-prone regions.
Kumar S; Singh SK; Wang X; Rup B; Gill D
Pharm Res; 2011 May; 28(5):949-61. PubMed ID: 21437790
[TBL] [Abstract][Full Text] [Related]
4. Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies.
Wang X; Das TK; Singh SK; Kumar S
MAbs; 2009; 1(3):254-67. PubMed ID: 20065649
[TBL] [Abstract][Full Text] [Related]
5. Rational design of therapeutic mAbs against aggregation through protein engineering and incorporation of glycosylation motifs applied to bevacizumab.
Courtois F; Agrawal NJ; Lauer TM; Trout BL
MAbs; 2016; 8(1):99-112. PubMed ID: 26514585
[TBL] [Abstract][Full Text] [Related]
6. A multiscale view of therapeutic protein aggregation: a colloid science perspective.
Nicoud L; Owczarz M; Arosio P; Morbidelli M
Biotechnol J; 2015 Mar; 10(3):367-78. PubMed ID: 25772395
[TBL] [Abstract][Full Text] [Related]
7. Developability index: a rapid in silico tool for the screening of antibody aggregation propensity.
Lauer TM; Agrawal NJ; Chennamsetty N; Egodage K; Helk B; Trout BL
J Pharm Sci; 2012 Jan; 101(1):102-15. PubMed ID: 21935950
[TBL] [Abstract][Full Text] [Related]
8. Biotransformation and in vivo stability of protein biotherapeutics: impact on candidate selection and pharmacokinetic profiling.
Hall MP
Drug Metab Dispos; 2014 Nov; 42(11):1873-80. PubMed ID: 24947971
[TBL] [Abstract][Full Text] [Related]
9. Computational models for the prediction of polypeptide aggregation propensity.
Caflisch A
Curr Opin Chem Biol; 2006 Oct; 10(5):437-44. PubMed ID: 16880001
[TBL] [Abstract][Full Text] [Related]
10. Prediction of aggregation prone regions of therapeutic proteins.
Chennamsetty N; Voynov V; Kayser V; Helk B; Trout BL
J Phys Chem B; 2010 May; 114(19):6614-24. PubMed ID: 20411962
[TBL] [Abstract][Full Text] [Related]
11. Relationship between potential aggregation-prone regions and HLA-DR-binding T-cell immune epitopes: implications for rational design of novel and follow-on therapeutic antibodies.
Kumar S; Mitchell MA; Rup B; Singh SK
J Pharm Sci; 2012 Aug; 101(8):2686-701. PubMed ID: 22619033
[TBL] [Abstract][Full Text] [Related]
12. AggScore: Prediction of aggregation-prone regions in proteins based on the distribution of surface patches.
Sankar K; Krystek SR; Carl SM; Day T; Maier JKX
Proteins; 2018 Nov; 86(11):1147-1156. PubMed ID: 30168197
[TBL] [Abstract][Full Text] [Related]
13. Coarse-grained models for protein aggregation.
Wu C; Shea JE
Curr Opin Struct Biol; 2011 Apr; 21(2):209-20. PubMed ID: 21371882
[TBL] [Abstract][Full Text] [Related]
14. A molecular dynamics approach to the structural characterization of amyloid aggregation.
Cecchini M; Curcio R; Pappalardo M; Melki R; Caflisch A
J Mol Biol; 2006 Apr; 357(4):1306-21. PubMed ID: 16483608
[TBL] [Abstract][Full Text] [Related]
15. Identification of properties important to protein aggregation using feature selection.
Fang Y; Gao S; Tai D; Middaugh CR; Fang J
BMC Bioinformatics; 2013 Oct; 14():314. PubMed ID: 24165390
[TBL] [Abstract][Full Text] [Related]
16. Solubis: a webserver to reduce protein aggregation through mutation.
Van Durme J; De Baets G; Van Der Kant R; Ramakers M; Ganesan A; Wilkinson H; Gallardo R; Rousseau F; Schymkowitz J
Protein Eng Des Sel; 2016 Aug; 29(8):285-9. PubMed ID: 27284085
[TBL] [Abstract][Full Text] [Related]
17. Prediction of the aggregation propensity of proteins from the primary sequence: aggregation properties of proteomes.
Castillo V; Graña-Montes R; Sabate R; Ventura S
Biotechnol J; 2011 Jun; 6(6):674-85. PubMed ID: 21538897
[TBL] [Abstract][Full Text] [Related]
18. Toward a molecular theory of early and late events in monomer to amyloid fibril formation.
Straub JE; Thirumalai D
Annu Rev Phys Chem; 2011; 62():437-63. PubMed ID: 21219143
[TBL] [Abstract][Full Text] [Related]
19. Predicting aggregation-prone sequences in proteins.
De Baets G; Schymkowitz J; Rousseau F
Essays Biochem; 2014; 56():41-52. PubMed ID: 25131585
[TBL] [Abstract][Full Text] [Related]
20. Structures and disulfide cross-linking of de novo designed therapeutic mini-proteins.
Silva DA; Stewart L; Lam KH; Jin R; Baker D
FEBS J; 2018 May; 285(10):1783-1785. PubMed ID: 29389072
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
