BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

100 related articles for article (PubMed ID: 21797275)

  • 1. Structure-activity relationship and pharmacokinetic studies of sotrastaurin (AEB071), a promising novel medicine for prevention of graft rejection and treatment of psoriasis.
    Wagner J; von Matt P; Faller B; Cooke NG; Albert R; Sedrani R; Wiegand H; Jean C; Beerli C; Weckbecker G; Evenou JP; Zenke G; Cottens S
    J Med Chem; 2011 Sep; 54(17):6028-39. PubMed ID: 21797275
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Sotrastaurin, a protein kinase C inhibitor for the prevention of transplant rejection and treatment of psoriasis.
    Manicassamy S
    Curr Opin Investig Drugs; 2009 Nov; 10(11):1225-35. PubMed ID: 19876790
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Overview of sotrastaurin clinical pharmacokinetics.
    Kovarik JM; Slade A
    Ther Drug Monit; 2010 Oct; 32(5):540-3. PubMed ID: 20683390
    [TBL] [Abstract][Full Text] [Related]  

  • 4. AEB071--a promising immunosuppressive agent.
    Sommerer C; Zeier M
    Clin Transplant; 2009 Dec; 23 Suppl 21():15-8. PubMed ID: 19930311
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.
    Wagner J; von Matt P; Sedrani R; Albert R; Cooke N; Ehrhardt C; Geiser M; Rummel G; Stark W; Strauss A; Cowan-Jacob SW; Beerli C; Weckbecker G; Evenou JP; Zenke G; Cottens S
    J Med Chem; 2009 Oct; 52(20):6193-6. PubMed ID: 19827831
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation.
    Evenou JP; Wagner J; Zenke G; Brinkmann V; Wagner K; Kovarik J; Welzenbach KA; Weitz-Schmidt G; Guntermann C; Towbin H; Cottens S; Kaminski S; Letschka T; Lutz-Nicoladoni C; Gruber T; Hermann-Kleiter N; Thuille N; Baier G
    J Pharmacol Exp Ther; 2009 Sep; 330(3):792-801. PubMed ID: 19491325
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Evaluation of the novel protein kinase C inhibitor sotrastaurin as immunosuppressive therapy after renal transplantation.
    Matz M; Naik M; Mashreghi MF; Glander P; Neumayer HH; Budde K
    Expert Opin Drug Metab Toxicol; 2011 Jan; 7(1):103-13. PubMed ID: 21142580
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Pharmacokinetics of sotrastaurin combined with tacrolimus or mycophenolic acid in de novo kidney transplant recipients.
    Kovarik JM; Steiger JU; Grinyo JM; Rostaing L; Arns W; Dantal J; Proot P; Budde K;
    Transplantation; 2011 Feb; 91(3):317-22. PubMed ID: 21157403
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Sotrastaurin single-dose pharmacokinetics in de novo liver transplant recipients.
    Kovarik JM; Neuhaus P; Cillo U; Weber M; Stitah S; Gatlik E; Meiser K; Slade A
    Transpl Int; 2011 Mar; 24(3):276-83. PubMed ID: 21134243
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Sotrastaurin and tacrolimus coadministration: effects on pharmacokinetics and biomarker responses.
    Kovarik JM; Stitah S; Slade A; Vitaliti A; Straube F; Grenet O; Winter S; Sfikas N; Seiberling M
    J Clin Pharmacol; 2010 Nov; 50(11):1260-6. PubMed ID: 20386017
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Effects of the novel protein kinase C inhibitor AEB071 (Sotrastaurin) on rat cardiac allograft survival using single agent treatment or combination therapy with cyclosporine, everolimus or FTY720.
    Weckbecker G; Pally C; Beerli C; Burkhart C; Wieczorek G; Metzler B; Morris RE; Wagner J; Bruns C
    Transpl Int; 2010 May; 23(5):543-52. PubMed ID: 20003043
    [TBL] [Abstract][Full Text] [Related]  

  • 12. PKCθ: a new target for selective immunosuppression.
    Altman A; Kong KF
    Expert Rev Clin Immunol; 2012 Mar; 8(3):205-8. PubMed ID: 22390482
    [No Abstract]   [Full Text] [Related]  

  • 13. AEB-071 versus tacrolimus monotherapy to prevent acute cardiac allograft rejection in the rat: a preliminary report.
    Fang YH; Joo DJ; Lim BJ; Kim JY; Kim MS; Jeong HJ; Kim YS
    Transplant Proc; 2010 Apr; 42(3):976-9. PubMed ID: 20430219
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Effects of the new immunosuppressive agent AEB071 on human immune cells.
    Matz M; Weber U; Mashreghi MF; Lorkowski C; Ladhoff J; Kramer S; Neumayer HH; Budde K
    Nephrol Dial Transplant; 2010 Jul; 25(7):2159-67. PubMed ID: 20100729
    [TBL] [Abstract][Full Text] [Related]  

  • 15. CP-690550, a JAK3 inhibitor as an immunosuppressant for the treatment of rheumatoid arthritis, transplant rejection, psoriasis and other immune-mediated disorders.
    West K
    Curr Opin Investig Drugs; 2009 May; 10(5):491-504. PubMed ID: 19431082
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Sotrastaurin and cyclosporine drug interaction study in healthy subjects.
    Kovarik JM; Stitah S; Slade A; Vitaliti A; Straube F; Grenet O; Winter S; Sfikas N; Seiberling M
    Biopharm Drug Dispos; 2010 Jul; 31(5-6):331-9. PubMed ID: 20578209
    [TBL] [Abstract][Full Text] [Related]  

  • 17. PKC-β as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL.
    El-Gamal D; Williams K; LaFollette TD; Cannon M; Blachly JS; Zhong Y; Woyach JA; Williams E; Awan FT; Jones J; Andritsos L; Maddocks K; Wu CH; Chen CS; Lehman A; Zhang X; Lapalombella R; Byrd JC
    Blood; 2014 Aug; 124(9):1481-91. PubMed ID: 25001469
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The PKC inhibitor AEB071 may be a therapeutic option for psoriasis.
    Skvara H; Dawid M; Kleyn E; Wolff B; Meingassner JG; Knight H; Dumortier T; Kopp T; Fallahi N; Stary G; Burkhart C; Grenet O; Wagner J; Hijazi Y; Morris RE; McGeown C; Rordorf C; Griffiths CE; Stingl G; Jung T
    J Clin Invest; 2008 Sep; 118(9):3151-9. PubMed ID: 18688284
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A novel series of low molecular weight immunosuppressive agents.
    Ocain TD; Bastos CM; Gordon KA; Granstein RD; Jenson JC; Jones B; McAuliffe DJ; Newcomb JR
    Transplant Proc; 1996 Dec; 28(6):3032-4. PubMed ID: 8962176
    [No Abstract]   [Full Text] [Related]  

  • 20. Sotrastaurin, a novel small molecule inhibiting protein kinase C: first clinical results in renal-transplant recipients.
    Budde K; Sommerer C; Becker T; Asderakis A; Pietruck F; Grinyo JM; Rigotti P; Dantal J; Ng J; Barten MJ; Weber M
    Am J Transplant; 2010 Mar; 10(3):571-81. PubMed ID: 20121745
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.