109 related articles for article (PubMed ID: 21802943)
1. N-(2-alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl)piperazine-1-carboxamides as highly potent smoothened antagonists.
Muraglia E; Ontoria JM; Branca D; Dessole G; Bresciani A; Fonsi M; Giuliano C; Llauger Bufi L; Monteagudo E; Palumbi MC; Torrisi C; Rowley M; Steinkühler C; Jones P
Bioorg Med Chem Lett; 2011 Sep; 21(18):5283-8. PubMed ID: 21802943
[TBL] [Abstract][Full Text] [Related]
2. Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitors.
Ontoria JM; Bufi LL; Torrisi C; Bresciani A; Giomini C; Rowley M; Serafini S; Bin H; Hao W; Steinkühler C; Jones P
Bioorg Med Chem Lett; 2011 Sep; 21(18):5274-82. PubMed ID: 21803580
[TBL] [Abstract][Full Text] [Related]
3. Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway.
Peukert S; Jain RK; Geisser A; Sun Y; Zhang R; Bourret A; Carlson A; Dasilva J; Ramamurthy A; Kelleher JF
Bioorg Med Chem Lett; 2009 Jan; 19(2):328-31. PubMed ID: 19091559
[TBL] [Abstract][Full Text] [Related]
4. Discovery of N-[(1-aryl-1H-indazol-5-yl)methyl]amides derivatives as smoothened antagonists for inhibition of the hedgehog pathway.
Dessole G; Branca D; Ferrigno F; Kinzel O; Muraglia E; Palumbi MC; Rowley M; Serafini S; Steinkühler C; Jones P
Bioorg Med Chem Lett; 2009 Aug; 19(15):4191-5. PubMed ID: 19540115
[TBL] [Abstract][Full Text] [Related]
5. SAR studies on a series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides: potent inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.
Gentles RG; Ding M; Zheng X; Chupak L; Poss MA; Beno BR; Pelosi L; Liu M; Lemm J; Wang YK; Roberts S; Gao M; Kadow J
Bioorg Med Chem Lett; 2011 May; 21(10):3142-7. PubMed ID: 21450465
[TBL] [Abstract][Full Text] [Related]
6. Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines.
Kaizerman JA; Aaron W; An S; Austin R; Brown M; Chong A; Huang T; Hungate R; Jiang B; Johnson MG; Lee G; Lucas BS; Orf J; Rong M; Toteva MM; Wickramasinghe D; Xu G; Ye Q; Zhong W; McMinn DL
Bioorg Med Chem Lett; 2010 Aug; 20(15):4607-10. PubMed ID: 20594845
[TBL] [Abstract][Full Text] [Related]
7. Evidence for allosteric interactions of antagonist binding to the smoothened receptor.
Rominger CM; Bee WL; Copeland RA; Davenport EA; Gilmartin A; Gontarek R; Hornberger KR; Kallal LA; Lai Z; Lawrie K; Lu Q; McMillan L; Truong M; Tummino PJ; Turunen B; Will M; Zuercher WJ; Rominger DH
J Pharmacol Exp Ther; 2009 Jun; 329(3):995-1005. PubMed ID: 19304771
[TBL] [Abstract][Full Text] [Related]
8. Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.
Leopoldo M; Berardi F; Colabufo NA; Contino M; Lacivita E; Niso M; Perrone R; Tortorella V
J Med Chem; 2004 Dec; 47(26):6616-24. PubMed ID: 15588097
[TBL] [Abstract][Full Text] [Related]
9. Design, synthesis, and structure--activity-relationship of tetrahydrothiazolopyridine derivatives as potent smoothened antagonists.
Ma H; Lu W; Sun Z; Luo L; Geng D; Yang Z; Li E; Zheng J; Wang M; Zhang H; Yang S; Zhang X
Eur J Med Chem; 2015 Jan; 89():721-32. PubMed ID: 25462278
[TBL] [Abstract][Full Text] [Related]
10. Scaffold hopping approach to a new series of smoothened antagonists.
Lu W; Geng D; Sun Z; Yang Z; Ma H; Zheng J; Zhang X
Bioorg Med Chem Lett; 2014 May; 24(10):2300-4. PubMed ID: 24726807
[TBL] [Abstract][Full Text] [Related]
11. Novel isoxazole carboxamides as growth hormone secretagogue receptor (GHS-R) antagonists.
Liu B; Liu G; Xin Z; Serby MD; Zhao H; Schaefer VG; Falls HD; Kaszubska W; Collins CA; Sham HL
Bioorg Med Chem Lett; 2004 Oct; 14(20):5223-6. PubMed ID: 15380232
[TBL] [Abstract][Full Text] [Related]
12. The discovery of potent antagonists of NPBWR1 (GPR7).
Anthony Romero F; Hastings NB; Moningka R; Guo Z; Wang M; Di Salvo J; Lei Y; Trusca D; Deng Q; Tong V; Terebetski JL; Ball RG; Ujjainwalla F
Bioorg Med Chem Lett; 2012 Jan; 22(2):1014-8. PubMed ID: 22197390
[TBL] [Abstract][Full Text] [Related]
13. Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonists.
Lucas BS; Aaron W; An S; Austin RJ; Brown M; Chan H; Chong A; Hungate R; Huang T; Jiang B; Johnson MG; Kaizerman JA; Lee G; McMinn DL; Orf J; Powers JP; Rong M; Toteva MM; Uyeda C; Wickramasinghe D; Xu G; Ye Q; Zhong W
Bioorg Med Chem Lett; 2010 Jun; 20(12):3618-22. PubMed ID: 20493695
[TBL] [Abstract][Full Text] [Related]
14. Parallel synthesis and dopamine D3/D2 receptor screening of novel {4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}carboxamides.
Heidler P; Zohrabi-Kalantari V; Calmels T; Capet M; Berrebi-Bertrand I; Schwartz JC; Stark H; Link A
Bioorg Med Chem; 2005 Mar; 13(6):2009-14. PubMed ID: 15727854
[TBL] [Abstract][Full Text] [Related]
15. First structure-activity relationship study on dopamine D3 receptor agents with N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamide structure.
Leopoldo M; Lacivita E; Colabufo NA; Contino M; Berardi F; Perrone R
J Med Chem; 2005 Dec; 48(25):7919-22. PubMed ID: 16335915
[TBL] [Abstract][Full Text] [Related]
16. Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist.
Roudaut H; Traiffort E; Gorojankina T; Vincent L; Faure H; Schoenfelder A; Mann A; Manetti F; Solinas A; Taddei M; Ruat M
Mol Pharmacol; 2011 Mar; 79(3):453-60. PubMed ID: 21177415
[TBL] [Abstract][Full Text] [Related]
17. Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO.
Yang B; Hird AW; Russell DJ; Fauber BP; Dakin LA; Zheng X; Su Q; Godin R; Brassil P; Devereaux E; Janetka JW
Bioorg Med Chem Lett; 2012 Jul; 22(14):4907-11. PubMed ID: 22704236
[TBL] [Abstract][Full Text] [Related]
18. Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists.
Xin Z; Zhao H; Serby MD; Liu B; Schaefer VG; Falls DH; Kaszubska W; Colins CA; Sham HL; Liu G
Bioorg Med Chem Lett; 2005 Feb; 15(4):1201-4. PubMed ID: 15686942
[TBL] [Abstract][Full Text] [Related]
19. Novel aryl and heteroaryl substituted N-[3-(4-phenylpiperazin-1-yl)propyl]-1,2,4-oxadiazole-5-carboxamides as selective GSK-3 inhibitors.
Koryakova AG; Ivanenkov YA; Ryzhova EA; Bulanova EA; Karapetian RN; Mikitas OV; Katrukha EA; Kazey VI; Okun I; Kravchenko DV; Lavrovsky YV; Korzinov OM; Ivachtchenko AV
Bioorg Med Chem Lett; 2008 Jun; 18(12):3661-6. PubMed ID: 18502121
[TBL] [Abstract][Full Text] [Related]
20. Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists.
Manetti F; Faure H; Roudaut H; Gorojankina T; Traiffort E; Schoenfelder A; Mann A; Solinas A; Taddei M; Ruat M
Mol Pharmacol; 2010 Oct; 78(4):658-65. PubMed ID: 20664000
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
