BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

157 related articles for article (PubMed ID: 21802957)

  • 21. Synthesis and biological assessment of simplified analogues of the potent microtubule stabilizer (+)-discodermolide.
    Mínguez JM; Kim SY; Giuliano KA; Balachandran R; Madiraju C; Day BW; Curran DP
    Bioorg Med Chem; 2003 Jul; 11(15):3335-57. PubMed ID: 12837544
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid.
    Paterson I; Gardner NM
    Chem Commun (Camb); 2007 Jan; (1):49-51. PubMed ID: 17279257
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Toward understanding how the lactone moiety of discodermolide affects activity.
    Shaw SJ; Sundermann KF; Burlingame MA; Myles DC; Freeze BS; Xian M; Brouard I; Smith AB
    J Am Chem Soc; 2005 May; 127(18):6532-3. PubMed ID: 15869264
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Structural Refinement of the Tubulin Ligand (+)-Discodermolide to Attenuate Chemotherapy-Mediated Senescence.
    Guo B; Rodriguez-Gabin A; Prota AE; Mühlethaler T; Zhang N; Ye K; Steinmetz MO; Horwitz SB; Smith AB; McDaid HM
    Mol Pharmacol; 2020 Aug; 98(2):156-167. PubMed ID: 32591477
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin.
    Madiraju C; Edler MC; Hamel E; Raccor BS; Balachandran R; Zhu G; Giuliano KA; Vogt A; Shin Y; Fournier JH; Fukui Y; Brückner AM; Curran DP; Day BW
    Biochemistry; 2005 Nov; 44(45):15053-63. PubMed ID: 16274252
    [TBL] [Abstract][Full Text] [Related]  

  • 26. The chemistry and biology of discodermolide.
    Kalesse M
    Chembiochem; 2000 Oct; 1(3):171-5. PubMed ID: 11828409
    [No Abstract]   [Full Text] [Related]  

  • 27. The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies.
    Martello LA; LaMarche MJ; He L; Beauchamp TJ; Smith AB; Horwitz SB
    Chem Biol; 2001 Sep; 8(9):843-55. PubMed ID: 11564553
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Total synthesis of the potent microtubule-stabilizing agent (+)-discodermolide.
    Harried SS; Lee CP; Yang G; Lee TI; Myles DC
    J Org Chem; 2003 Aug; 68(17):6646-60. PubMed ID: 12919029
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Synthesis of (+)-discodermolide by catalytic stereoselective borylation reactions.
    Yu Z; Ely RJ; Morken JP
    Angew Chem Int Ed Engl; 2014 Sep; 53(36):9632-6. PubMed ID: 25045037
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol.
    ter Haar E; Kowalski RJ; Hamel E; Lin CM; Longley RE; Gunasekera SP; Rosenkranz HS; Day BW
    Biochemistry; 1996 Jan; 35(1):243-50. PubMed ID: 8555181
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin.
    Florence GJ; Gardner NM; Paterson I
    Nat Prod Rep; 2008 Apr; 25(2):342-75. PubMed ID: 18389141
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Short synthesis of the C1-C14 stretch of discodermolide from building blocks prepared by asymmetric catalysis.
    Cao H; Parker KA
    Org Lett; 2008 Apr; 10(7):1353-6. PubMed ID: 18311989
    [TBL] [Abstract][Full Text] [Related]  

  • 33. (+)-discodermolide: a marine natural product against cancer.
    De Souza MV
    ScientificWorldJournal; 2004 Jun; 4():415-36. PubMed ID: 15243683
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Structure-activity relationship studies of discodermolide and its semisynthetic acetylated analogs on microtubule function and cytotoxicity.
    Isbrucker RA; Gunasekera SP; Longley RE
    Cancer Chemother Pharmacol; 2001 Jul; 48(1):29-36. PubMed ID: 11488521
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Discodermolide/Dictyostatin hybrids: synthesis and biological evaluation.
    Shin Y; Choy N; Turner TR; Balachandran R; Madiraju C; Day BW; Curran DP
    Org Lett; 2002 Dec; 4(25):4443-6. PubMed ID: 12465908
    [TBL] [Abstract][Full Text] [Related]  

  • 36. (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest.
    Hung DT; Chen J; Schreiber SL
    Chem Biol; 1996 Apr; 3(4):287-93. PubMed ID: 8807856
    [TBL] [Abstract][Full Text] [Related]  

  • 37. The bound conformation of microtubule-stabilizing agents: NMR insights into the bioactive 3D structure of discodermolide and dictyostatin.
    Canales A; Matesanz R; Gardner NM; Andreu JM; Paterson I; Díaz JF; Jiménez-Barbero J
    Chemistry; 2008; 14(25):7557-69. PubMed ID: 18449868
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Decarboxylative Grob-type fragmentations in the synthesis of trisubstituted Z olefins: application to peloruside A, discodermolide, and epothilone D.
    Prantz K; Mulzer J
    Angew Chem Int Ed Engl; 2009; 48(27):5030-3. PubMed ID: 19492384
    [TBL] [Abstract][Full Text] [Related]  

  • 39. The discodermolide hairpin structure flows from conformationally stable modular motifs.
    Jogalekar AS; Kriel FH; Shi Q; Cornett B; Cicero D; Snyder JP
    J Med Chem; 2010 Jan; 53(1):155-65. PubMed ID: 19894728
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Synthetic analogues of the microtubule-stabilizing agent (+)-discodermolide: preparation and biological activity.
    Gunasekera SP; Mickel SJ; Daeffler R; Niederer D; Wright AE; Linley P; Pitts T
    J Nat Prod; 2004 May; 67(5):749-56. PubMed ID: 15165132
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.