BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

114 related articles for article (PubMed ID: 2182010)

  • 1. Effects of replacement of tryptophan-140 by phenylalanine or glycine on the function of Escherichia coli aspartate aminotransferase.
    Hayashi H; Inoue Y; Kuramitsu S; Morino Y; Kagamiyama H
    Biochem Biophys Res Commun; 1990 Mar; 167(2):407-12. PubMed ID: 2182010
    [TBL] [Abstract][Full Text] [Related]  

  • 2. [Arg292----Val] or [Arg292----Leu] mutation enhances the reactivity of Escherichia coli aspartate aminotransferase with aromatic amino acids.
    Hayashi H; Kuramitsu S; Inoue Y; Morino Y; Kagamiyama H
    Biochem Biophys Res Commun; 1989 Feb; 159(1):337-42. PubMed ID: 2564274
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Replacement of an interdomain residue Val39 of Escherichia coli aspartate aminotransferase affects the catalytic competence without altering the substrate specificity of the enzyme.
    Hayashi H; Kuramitsu S; Kagamiyama H
    J Biochem; 1991 May; 109(5):699-704. PubMed ID: 1917893
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The tyrosine-225 to phenylalanine mutation of Escherichia coli aspartate aminotransferase results in an alkaline transition in the spectrophotometric and kinetic pKa values and reduced values of both kcat and Km.
    Goldberg JM; Swanson RV; Goodman HS; Kirsch JF
    Biochemistry; 1991 Jan; 30(1):305-12. PubMed ID: 1988027
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Escherichia coli aromatic amino acid aminotransferase: characterization and comparison with aspartate aminotransferase.
    Hayashi H; Inoue K; Nagata T; Kuramitsu S; Kagamiyama H
    Biochemistry; 1993 Nov; 32(45):12229-39. PubMed ID: 8218300
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Substitution of apolar residues in the active site of aspartate aminotransferase by histidine. Effects on reaction and substrate specificity.
    Vacca RA; Christen P; Malashkevich VN; Jansonius JN; Sandmeier E
    Eur J Biochem; 1995 Jan; 227(1-2):481-7. PubMed ID: 7851426
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Active-site Arg --> Lys substitutions alter reaction and substrate specificity of aspartate aminotransferase.
    Vacca RA; Giannattasio S; Graber R; Sandmeier E; Marra E; Christen P
    J Biol Chem; 1997 Aug; 272(35):21932-7. PubMed ID: 9268327
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Shift in pH-rate profile and enhanced discrimination between dicarboxylic and aromatic substrates in mitochondrial aspartate aminotransferase Y70H.
    Pan P; Jaussi R; Gehring H; Giannattasio S; Christen P
    Biochemistry; 1994 Mar; 33(10):2757-60. PubMed ID: 8130187
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Redesign of the substrate specificity of Escherichia coli aspartate aminotransferase to that of Escherichia coli tyrosine aminotransferase by homology modeling and site-directed mutagenesis.
    Onuffer JJ; Kirsch JF
    Protein Sci; 1995 Sep; 4(9):1750-7. PubMed ID: 8528073
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Narrowing substrate specificity in a directly evolved enzyme: the A293D mutant of aspartate aminotransferase.
    Chow MA; McElroy KE; Corbett KD; Berger JM; Kirsch JF
    Biochemistry; 2004 Oct; 43(40):12780-7. PubMed ID: 15461450
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Aspartate aminotransferase of E. coli: effects of site-directed mutagenesis on substrate recognition.
    Kagamiyama H
    J Nutr Sci Vitaminol (Tokyo); 1992; Spec No():216-9. PubMed ID: 1297744
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Quantitative chimeric analysis of six specificity determinants that differentiate Escherichia coli aspartate from tyrosine aminotransferase.
    Shaffer WA; Luong TN; Rothman SC; Kirsch JF
    Protein Sci; 2002 Dec; 11(12):2848-59. PubMed ID: 12441383
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Directed evolution relieves product inhibition and confers in vivo function to a rationally designed tyrosine aminotransferase.
    Rothman SC; Voorhies M; Kirsch JF
    Protein Sci; 2004 Mar; 13(3):763-72. PubMed ID: 14767072
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Activity and structure of the active-site mutants R386Y and R386F of Escherichia coli aspartate aminotransferase.
    Danishefsky AT; Onnufer JJ; Petsko GA; Ringe D
    Biochemistry; 1991 Feb; 30(7):1980-5. PubMed ID: 1993208
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Activation of aspartase by site-directed mutagenesis.
    Murase S; Takagi JS; Higashi Y; Imaishi H; Yumoto N; Tokushige M
    Biochem Biophys Res Commun; 1991 May; 177(1):414-9. PubMed ID: 2043125
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Role of tryptophan 248 in the active site of tryptophanase from Escherichia coli.
    Kawata Y; Tsujimoto N; Tani S; Mizobata T; Tokushige M
    Biochem Biophys Res Commun; 1990 Dec; 173(2):756-62. PubMed ID: 2260981
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Changing the reaction specificity of a pyridoxal-5'-phosphate-dependent enzyme.
    Graber R; Kasper P; Malashkevich VN; Sandmeier E; Berger P; Gehring H; Jansonius JN; Christen P
    Eur J Biochem; 1995 Sep; 232(2):686-90. PubMed ID: 7556224
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The reaction catalyzed by Escherichia coli aspartate aminotransferase has multiple partially rate-determining steps, while that catalyzed by the Y225F mutant is dominated by ketimine hydrolysis.
    Goldberg JM; Kirsch JF
    Biochemistry; 1996 Apr; 35(16):5280-91. PubMed ID: 8611515
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Tyr225 in aspartate aminotransferase: contribution of the hydrogen bond between Tyr225 and coenzyme to the catalytic reaction.
    Inoue K; Kuramitsu S; Okamoto A; Hirotsu K; Higuchi T; Morino Y; Kagamiyama H
    J Biochem; 1991 Apr; 109(4):570-6. PubMed ID: 1869510
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Three-dimensional structure of a mutant E. coli aspartate aminotransferase with increased enzymic activity.
    Jäger J; Pauptit RA; Sauder U; Jansonius JN
    Protein Eng; 1994 May; 7(5):605-12. PubMed ID: 8073030
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.