BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

102 related articles for article (PubMed ID: 21822123)

  • 1. Identification of a checkpoint modulator with synthetic lethality to p53 mutants.
    Harada N; Watanabe Y; Yoshimura Y; Sakumoto H; Makishima F; Tsuchiya M; Nakanishi K; Nakanishi M; Aoki Y
    Anticancer Drugs; 2011 Nov; 22(10):986-94. PubMed ID: 21822123
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Cadmium-induced DNA damage triggers G(2)/M arrest via chk1/2 and cdc2 in p53-deficient kidney proximal tubule cells.
    Bork U; Lee WK; Kuchler A; Dittmar T; Thévenod F
    Am J Physiol Renal Physiol; 2010 Feb; 298(2):F255-65. PubMed ID: 19923412
    [TBL] [Abstract][Full Text] [Related]  

  • 3. UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1.
    Yu Q; La Rose J; Zhang H; Takemura H; Kohn KW; Pommier Y
    Cancer Res; 2002 Oct; 62(20):5743-8. PubMed ID: 12384533
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy.
    Iwata T; Uchino T; Koyama A; Johmura Y; Koyama K; Saito T; Ishiguro S; Arikawa T; Komatsu S; Miyachi M; Sano T; Nakanishi M; Shimada M
    PLoS One; 2017; 12(5):e0178221. PubMed ID: 28558031
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional.
    Lossaint G; Besnard E; Fisher D; Piette J; Dulić V
    Oncogene; 2011 Oct; 30(41):4261-74. PubMed ID: 21532626
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The impact of S- and G2-checkpoint response on the fidelity of G1-arrest by cisplatin and its comparison to a non-cross-resistant platinum(IV) analog.
    He G; Kuang J; Khokhar AR; Siddik ZH
    Gynecol Oncol; 2011 Aug; 122(2):402-9. PubMed ID: 21592546
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Resveratrol analogue (E)-8-acetoxy-2-[2-(3,4-diacetoxyphenyl)ethenyl]-quinazoline induces G₂/M cell cycle arrest through the activation of ATM/ATR in human cervical carcinoma HeLa cells.
    Kim JY; Choi HE; Lee HH; Shin JS; Shin DH; Choi JH; Lee YS; Lee KT
    Oncol Rep; 2015 May; 33(5):2639-47. PubMed ID: 25812484
    [TBL] [Abstract][Full Text] [Related]  

  • 8. p53-dependent Chk1 phosphorylation is required for maintenance of prolonged G2 Arrest.
    Wang XQ; Stanbridge EJ; Lao X; Cai Q; Fan ST; Redpath JL
    Radiat Res; 2007 Dec; 168(6):706-15. PubMed ID: 18088187
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Chk1, but not Chk2, is involved in the cellular response to DNA damaging agents: differential activity in cells expressing or not p53.
    Carrassa L; Broggini M; Erba E; Damia G
    Cell Cycle; 2004 Sep; 3(9):1177-81. PubMed ID: 15326376
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator.
    Wang Y; Li J; Booher RN; Kraker A; Lawrence T; Leopold WR; Sun Y
    Cancer Res; 2001 Nov; 61(22):8211-7. PubMed ID: 11719452
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells.
    Hirose Y; Berger MS; Pieper RO
    Cancer Res; 2001 Aug; 61(15):5843-9. PubMed ID: 11479224
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells.
    Shao RG; Cao CX; Pommier Y
    Acta Pharmacol Sin; 2004 Jun; 25(6):756-62. PubMed ID: 15169628
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Involvement of the role of Chk1 in lithium-induced G2/M phase cell cycle arrest in hepatocellular carcinoma cells.
    Wang XM; Li J; Feng XC; Wang Q; Guan DY; Shen ZH
    J Cell Biochem; 2008 Jul; 104(4):1181-91. PubMed ID: 18247328
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Carcinogen-induced S-phase arrest is Chk1 mediated and caffeine sensitive.
    Guo N; Faller DV; Vaziri C
    Cell Growth Differ; 2002 Feb; 13(2):77-86. PubMed ID: 11864911
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Bortezomib induces G2-M arrest in human colon cancer cells through ROS-inducible phosphorylation of ATM-CHK1.
    Hong YS; Hong SW; Kim SM; Jin DH; Shin JS; Yoon DH; Kim KP; Lee JL; Heo DS; Lee JS; Kim TW
    Int J Oncol; 2012 Jul; 41(1):76-82. PubMed ID: 22552540
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Molecular basis for G2 arrest induced by 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine and consequences of checkpoint abrogation.
    Liu X; Guo Y; Li Y; Jiang Y; Chubb S; Azuma A; Huang P; Matsuda A; Hittelman W; Plunkett W
    Cancer Res; 2005 Aug; 65(15):6874-81. PubMed ID: 16061671
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells.
    Poon RY; Chau MS; Yamashita K; Hunter T
    Cancer Res; 1997 Nov; 57(22):5168-78. PubMed ID: 9371520
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Chk1 and Wee1 control genotoxic-stress induced G2-M arrest in melanoma cells.
    Vera J; Raatz Y; Wolkenhauer O; Kottek T; Bhattacharya A; Simon JC; Kunz M
    Cell Signal; 2015 May; 27(5):951-60. PubMed ID: 25683911
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition.
    Meng F; Bhupathi D; Sun JD; Liu Q; Ahluwalia D; Wang Y; Matteucci MD; Hart CP
    BMC Cancer; 2015 May; 15():422. PubMed ID: 25994202
    [TBL] [Abstract][Full Text] [Related]  

  • 20. CBP-93872 inhibits NBS1-mediated ATR activation, abrogating maintenance of the DNA double-strand break-specific G2 checkpoint.
    Hirokawa T; Shiotani B; Shimada M; Murata K; Johmura Y; Haruta M; Tahara H; Takeyama H; Nakanishi M
    Cancer Res; 2014 Jul; 74(14):3880-9. PubMed ID: 24876101
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.