200 related articles for article (PubMed ID: 21832286)
1. Role of the transmembrane domain 4/extracellular loop 2 junction of the human gonadotropin-releasing hormone receptor in ligand binding and receptor conformational selection.
Forfar R; Lu ZL
J Biol Chem; 2011 Oct; 286(40):34617-26. PubMed ID: 21832286
[TBL] [Abstract][Full Text] [Related]
2. Mutations remote from the human gonadotropin-releasing hormone (GnRH) receptor-binding sites specifically increase binding affinity for GnRH II but not GnRH I: evidence for ligand-selective, receptor-active conformations.
Lu ZL; Gallagher R; Sellar R; Coetsee M; Millar RP
J Biol Chem; 2005 Aug; 280(33):29796-803. PubMed ID: 15967801
[TBL] [Abstract][Full Text] [Related]
3. Structural determinants for ligand-receptor conformational selection in a peptide G protein-coupled receptor.
Lu ZL; Coetsee M; White CD; Millar RP
J Biol Chem; 2007 Jun; 282(24):17921-9. PubMed ID: 17452338
[TBL] [Abstract][Full Text] [Related]
4. Conserved amino acid residues that are important for ligand binding in the type I gonadotropin-releasing hormone (GnRH) receptor are required for high potency of GnRH II at the type II GnRH receptor.
Mamputha S; Lu ZL; Roeske RW; Millar RP; Katz AA; Flanagan CA
Mol Endocrinol; 2007 Jan; 21(1):281-92. PubMed ID: 16973761
[TBL] [Abstract][Full Text] [Related]
5. Alanine-261 in intracellular loop III of the human gonadotropin-releasing hormone receptor is crucial for G-protein coupling and receptor internalization.
Myburgh DB; Millar RP; Hapgood JP
Biochem J; 1998 May; 331 ( Pt 3)(Pt 3):893-6. PubMed ID: 9560319
[TBL] [Abstract][Full Text] [Related]
6. Long range effect of mutations on specific conformational changes in the extracellular loop 2 of angiotensin II type 1 receptor.
Unal H; Jagannathan R; Bhatnagar A; Tirupula K; Desnoyer R; Karnik SS
J Biol Chem; 2013 Jan; 288(1):540-51. PubMed ID: 23139413
[TBL] [Abstract][Full Text] [Related]
7. Secondary structure of the third extracellular loop responsible for ligand selectivity of a mammalian gonadotropin-releasing hormone receptor.
Petry R; Craik D; Haaima G; Fromme B; Klump H; Kiefer W; Palm D; Millar R
J Med Chem; 2002 Feb; 45(5):1026-34. PubMed ID: 11855982
[TBL] [Abstract][Full Text] [Related]
8. Evolution of constrained gonadotropin-releasing hormone ligand conformation and receptor selectivity.
Barran PE; Roeske RW; Pawson AJ; Sellar R; Bowers MT; Morgan K; Lu ZL; Tsuda M; Kusakabe T; Millar RP
J Biol Chem; 2005 Nov; 280(46):38569-75. PubMed ID: 16157590
[TBL] [Abstract][Full Text] [Related]
9. Extracellular loop 3 (EL3) and EL3-proximal transmembrane helix 7 of the mammalian type I and type II gonadotropin-releasing hormone (GnRH) receptors determine differential ligand selectivity to GnRH-I and GnRH-II.
Li JH; Choe H; Wang AF; Maiti K; Wang C; Salam A; Chun SY; Lee WK; Kim K; Kwon HB; Seong JY
Mol Pharmacol; 2005 Apr; 67(4):1099-110. PubMed ID: 15635044
[TBL] [Abstract][Full Text] [Related]
10. Histidine(7.36(305)) in the conserved peptide receptor activation domain of the gonadotropin releasing hormone receptor couples peptide binding and receptor activation.
Mayevu NM; Choe H; Abagyan R; Seong JY; Millar RP; Katz AA; Flanagan CA
Mol Cell Endocrinol; 2015 Feb; 402():95-106. PubMed ID: 25583361
[TBL] [Abstract][Full Text] [Related]
11. Salt bridges overlapping the gonadotropin-releasing hormone receptor agonist binding site reveal a coincidence detector for G protein-coupled receptor activation.
Janovick JA; Pogozheva ID; Mosberg HI; Conn PM
J Pharmacol Exp Ther; 2011 Aug; 338(2):430-42. PubMed ID: 21527534
[TBL] [Abstract][Full Text] [Related]
12. An intramolecular disulfide bond between conserved extracellular cysteines in the gonadotropin-releasing hormone receptor is essential for binding and activation.
Cook JV; Eidne KA
Endocrinology; 1997 Jul; 138(7):2800-6. PubMed ID: 9202220
[TBL] [Abstract][Full Text] [Related]
13. Gonadotropin-Releasing Hormone (GnRH) Receptor Structure and GnRH Binding.
Flanagan CA; Manilall A
Front Endocrinol (Lausanne); 2017; 8():274. PubMed ID: 29123501
[TBL] [Abstract][Full Text] [Related]
14. Identification of Tyr(290(6.58)) of the human gonadotropin-releasing hormone (GnRH) receptor as a contact residue for both GnRH I and GnRH II: importance for high-affinity binding and receptor activation.
Coetsee M; Millar RP; Flanagan CA; Lu ZL
Biochemistry; 2008 Sep; 47(39):10305-13. PubMed ID: 18771291
[TBL] [Abstract][Full Text] [Related]
15. Identification of a novel ligand binding residue Arg38(1.35) in the human gonadotropin-releasing hormone receptor.
Stewart AJ; Sellar R; Wilson DJ; Millar RP; Lu ZL
Mol Pharmacol; 2008 Jan; 73(1):75-81. PubMed ID: 17942747
[TBL] [Abstract][Full Text] [Related]
16. Changes to gonadotropin-releasing hormone (GnRH) receptor extracellular loops differentially affect GnRH analog binding and activation: evidence for distinct ligand-stabilized receptor conformations.
Pfleger KD; Pawson AJ; Millar RP
Endocrinology; 2008 Jun; 149(6):3118-29. PubMed ID: 18356273
[TBL] [Abstract][Full Text] [Related]
17. Refinement of the gonadotropin releasing hormone receptor I homology model by applying molecular dynamics.
Tzoupis H; Nteli A; Platts J; Mantzourani E; Tselios T
J Mol Graph Model; 2019 Jun; 89():147-155. PubMed ID: 30889428
[TBL] [Abstract][Full Text] [Related]
18. Identification of Ser153 in ICL2 of the gonadotropin-releasing hormone (GnRH) receptor as a phosphorylation-independent site for inhibition of Gq coupling.
Shacham S; Cheifetz MN; Fridkin M; Pawson AJ; Millar RP; Naor Z
J Biol Chem; 2005 Aug; 280(32):28981-8. PubMed ID: 15964850
[TBL] [Abstract][Full Text] [Related]
19. Glutamate 301 of the mouse gonadotropin-releasing hormone receptor confers specificity for arginine 8 of mammalian gonadotropin-releasing hormone.
Flanagan CA; Becker II; Davidson JS; Wakefield IK; Zhou W; Sealfon SC; Millar RP
J Biol Chem; 1994 Sep; 269(36):22636-41. PubMed ID: 7915716
[TBL] [Abstract][Full Text] [Related]
20. Mutation Ala(171)Thr stabilizes the gonadotropin-releasing hormone receptor in its inactive conformation, causing familial hypogonadotropic hypogonadism.
Karges B; Karges W; Mine M; Ludwig L; Kühne R; Milgrom E; de Roux N
J Clin Endocrinol Metab; 2003 Apr; 88(4):1873-9. PubMed ID: 12679486
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]