These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

278 related articles for article (PubMed ID: 21833767)

  • 1. A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition.
    Ilari A; Baiocco P; Messori L; Fiorillo A; Boffi A; Gramiccia M; Di Muccio T; Colotti G
    Amino Acids; 2012 Feb; 42(2-3):803-11. PubMed ID: 21833767
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-guided approach to identify a novel class of anti-leishmaniasis diaryl sulfide compounds targeting the trypanothione metabolism.
    Colotti G; Saccoliti F; Gramiccia M; Di Muccio T; Prakash J; Yadav S; Dubey VK; Vistoli G; Battista T; Mocci S; Fiorillo A; Bibi A; Madia VN; Messore A; Costi R; Di Santo R; Ilari A
    Amino Acids; 2020 Feb; 52(2):247-259. PubMed ID: 31037461
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives.
    Saccoliti F; Angiulli G; Pupo G; Pescatori L; Madia VN; Messore A; Colotti G; Fiorillo A; Scipione L; Gramiccia M; Di Muccio T; Di Santo R; Costi R; Ilari A
    J Enzyme Inhib Med Chem; 2017 Dec; 32(1):304-310. PubMed ID: 28098499
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Metal-based compounds as prospective antileishmanial agents: inhibition of trypanothione reductase by selected gold complexes.
    Colotti G; Ilari A; Fiorillo A; Baiocco P; Cinellu MA; Maiore L; Scaletti F; Gabbiani C; Messori L
    ChemMedChem; 2013 Oct; 8(10):1634-7. PubMed ID: 24039168
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallography.
    Baiocco P; Poce G; Alfonso S; Cocozza M; Porretta GC; Colotti G; Biava M; Moraca F; Botta M; Yardley V; Fiorillo A; Lantella A; Malatesta F; Ilari A
    ChemMedChem; 2013 Jul; 8(7):1175-83. PubMed ID: 23733388
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs.
    Colotti G; Baiocco P; Fiorillo A; Boffi A; Poser E; Chiaro FD; Ilari A
    Future Med Chem; 2013 Oct; 5(15):1861-75. PubMed ID: 24144416
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Molecular docking studies of selected tricyclic and quinone derivatives on trypanothione reductase of Leishmania infantum.
    Venkatesan SK; Shukla AK; Dubey VK
    J Comput Chem; 2010 Oct; 31(13):2463-75. PubMed ID: 20340105
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Trypanothione reductase from Leishmania infantum: cloning, expression, purification, crystallization and preliminary X-ray data analysis.
    Baiocco P; Franceschini S; Ilari A; Colotti G
    Protein Pept Lett; 2009; 16(2):196-200. PubMed ID: 19200044
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Molecular basis of antimony treatment in leishmaniasis.
    Baiocco P; Colotti G; Franceschini S; Ilari A
    J Med Chem; 2009 Apr; 52(8):2603-12. PubMed ID: 19317451
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Probing the dimerization interface of Leishmania infantum trypanothione reductase with site-directed mutagenesis and short peptides.
    Toro MA; Sánchez-Murcia PA; Moreno D; Ruiz-Santaquiteria M; Alzate JF; Negri A; Camarasa MJ; Gago F; Velázquez S; Jiménez-Ruiz A
    Chembiochem; 2013 Jul; 14(10):1212-7. PubMed ID: 23744811
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Modeled structure of trypanothione reductase of Leishmania infantum.
    Singh BK; Sarkar N; Jagannadham MV; Dubey VK
    BMB Rep; 2008 Jun; 41(6):444-7. PubMed ID: 18593527
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of chalcone-based antileishmanial agents targeting trypanothione reductase.
    Ortalli M; Ilari A; Colotti G; De Ionna I; Battista T; Bisi A; Gobbi S; Rampa A; Di Martino RMC; Gentilomi GA; Varani S; Belluti F
    Eur J Med Chem; 2018 May; 152():527-541. PubMed ID: 29758517
    [TBL] [Abstract][Full Text] [Related]  

  • 13. First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent in vitro antileishmanial activity
    Ruiz-Santaquiteria M; Sánchez-Murcia PA; Toro MA; de Lucio H; Gutiérrez KJ; de Castro S; Carneiro FAC; Gago F; Jiménez-Ruiz A; Camarasa MJ; Velázquez S
    Eur J Med Chem; 2017 Jul; 135():49-59. PubMed ID: 28431354
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening.
    Turcano L; Torrente E; Missineo A; Andreini M; Gramiccia M; Di Muccio T; Genovese I; Fiorillo A; Harper S; Bresciani A; Colotti G; Ilari A
    PLoS Negl Trop Dis; 2018 Nov; 12(11):e0006969. PubMed ID: 30475811
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pyridazino-pyrrolo-quinoxalinium salts as highly potent and selective leishmanicidal agents targeting trypanothione reductase.
    de Lucio H; García-Marín J; Sánchez-Alonso P; García-Soriano JC; Toro MÁ; Vaquero JJ; Gago F; Alajarín R; Jiménez-Ruiz A
    Eur J Med Chem; 2022 Jan; 227():113915. PubMed ID: 34695777
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibition of
    Madia VN; Ialongo D; Patacchini E; Exertier C; Antonelli L; Colotti G; Messore A; Tudino V; Saccoliti F; Scipione L; Ilari A; Costi R; Di Santo R
    Molecules; 2023 Jan; 28(1):. PubMed ID: 36615531
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects.
    Angelucci F; Sayed AA; Williams DL; Boumis G; Brunori M; Dimastrogiovanni D; Miele AE; Pauly F; Bellelli A
    J Biol Chem; 2009 Oct; 284(42):28977-85. PubMed ID: 19710012
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Leishmania infantum trypanothione reductase is a promiscuous enzyme carrying an NADPH:O2 oxidoreductase activity shared by glutathione reductase.
    Angiulli G; Lantella A; Forte E; Angelucci F; Colotti G; Ilari A; Malatesta F
    Biochim Biophys Acta; 2015 Sep; 1850(9):1891-7. PubMed ID: 26033467
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors.
    Bond CS; Zhang Y; Berriman M; Cunningham ML; Fairlamb AH; Hunter WN
    Structure; 1999 Jan; 7(1):81-9. PubMed ID: 10368274
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Efficient Dimerization Disruption of
    Revuelto A; de Lucio H; García-Soriano JC; Sánchez-Murcia PA; Gago F; Jiménez-Ruiz A; Camarasa MJ; Velázquez S
    J Med Chem; 2021 May; 64(9):6137-6160. PubMed ID: 33945281
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.