306 related articles for article (PubMed ID: 21839782)
1. Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt.
Mullen PJ; Zahno A; Lindinger P; Maseneni S; Felser A; Krähenbühl S; Brecht K
Biochim Biophys Acta; 2011 Dec; 1813(12):2079-87. PubMed ID: 21839782
[TBL] [Abstract][Full Text] [Related]
2. IGF-1 prevents simvastatin-induced myotoxicity in C2C12 myotubes.
Bonifacio A; Sanvee GM; Brecht K; Kratschmar DV; Odermatt A; Bouitbir J; Krähenbühl S
Arch Toxicol; 2017 May; 91(5):2223-2234. PubMed ID: 27734117
[TBL] [Abstract][Full Text] [Related]
3. AMP-activated protein kinase enhances the expression of muscle-specific ubiquitin ligases despite its activation of IGF-1/Akt signaling in C2C12 myotubes.
Tong JF; Yan X; Zhu MJ; Du M
J Cell Biochem; 2009 Oct; 108(2):458-68. PubMed ID: 19639604
[TBL] [Abstract][Full Text] [Related]
4. Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes.
Kwak HB; Thalacker-Mercer A; Anderson EJ; Lin CT; Kane DA; Lee NS; Cortright RN; Bamman MM; Neufer PD
Free Radic Biol Med; 2012 Jan; 52(1):198-207. PubMed ID: 22080086
[TBL] [Abstract][Full Text] [Related]
5. Effect of simvastatin on cholesterol metabolism in C2C12 myotubes and HepG2 cells, and consequences for statin-induced myopathy.
Mullen PJ; Lüscher B; Scharnagl H; Krähenbühl S; Brecht K
Biochem Pharmacol; 2010 Apr; 79(8):1200-9. PubMed ID: 20018177
[TBL] [Abstract][Full Text] [Related]
6. The AKT/mTOR signaling pathway plays a key role in statin-induced myotoxicity.
Bonifacio A; Sanvee GM; Bouitbir J; Krähenbühl S
Biochim Biophys Acta; 2015 Aug; 1853(8):1841-9. PubMed ID: 25913013
[TBL] [Abstract][Full Text] [Related]
7. mTORC2 is an important target for simvastatin-associated toxicity in C2C12 cells and mouse skeletal muscle - Roles of Rap1 geranylgeranylation and mitochondrial dysfunction.
Sanvee GM; Hitzfeld L; Bouitbir J; Krähenbühl S
Biochem Pharmacol; 2021 Oct; 192():114750. PubMed ID: 34461118
[TBL] [Abstract][Full Text] [Related]
8. Simvastatin inhibits glucose uptake activity and GLUT4 translocation through suppression of the IR/IRS-1/Akt signaling in C2C12 myotubes.
Li W; Liang X; Zeng Z; Yu K; Zhan S; Su Q; Yan Y; Mansai H; Qiao W; Yang Q; Qi Z; Huang Z
Biomed Pharmacother; 2016 Oct; 83():194-200. PubMed ID: 27470565
[TBL] [Abstract][Full Text] [Related]
9. Mechanisms of insulin resistance by simvastatin in C2C12 myotubes and in mouse skeletal muscle.
Sanvee GM; Panajatovic MV; Bouitbir J; Krähenbühl S
Biochem Pharmacol; 2019 Jun; 164():23-33. PubMed ID: 30796916
[TBL] [Abstract][Full Text] [Related]
10. Effects of combined hormone replacement therapy or its effective agents on the IGF-1 pathway in skeletal muscle.
Pöllänen E; Ronkainen PH; Horttanainen M; Takala T; Puolakka J; Suominen H; Sipilä S; Kovanen V
Growth Horm IGF Res; 2010 Oct; 20(5):372-9. PubMed ID: 20724185
[TBL] [Abstract][Full Text] [Related]
11. Chemerin-induced mitochondrial dysfunction in skeletal muscle.
Xie Q; Deng Y; Huang C; Liu P; Yang Y; Shen W; Gao P
J Cell Mol Med; 2015 May; 19(5):986-95. PubMed ID: 25754411
[TBL] [Abstract][Full Text] [Related]
12. Angiotensin-(1-7) decreases skeletal muscle atrophy induced by angiotensin II through a Mas receptor-dependent mechanism.
Cisternas F; Morales MG; Meneses C; Simon F; Brandan E; Abrigo J; Vazquez Y; Cabello-Verrugio C
Clin Sci (Lond); 2015 Mar; 128(5):307-19. PubMed ID: 25222828
[TBL] [Abstract][Full Text] [Related]
13. Insulin prevents and reverts simvastatin-induced toxicity in C2C12 skeletal muscle cells.
Sanvee GM; Bouitbir J; Krähenbühl S
Sci Rep; 2019 May; 9(1):7409. PubMed ID: 31092879
[TBL] [Abstract][Full Text] [Related]
14. 20(s)‑ginseonside‑Rg3 modulation of AMPK/FoxO3 signaling to attenuate mitochondrial dysfunction in a dexamethasone‑injured C2C12 myotube‑based model of skeletal atrophy
Wang M; Jiang R; Liu J; Xu X; Sun G; Zhao D; Sun L
Mol Med Rep; 2021 May; 23(5):. PubMed ID: 33649814
[TBL] [Abstract][Full Text] [Related]
15. TNF induction of atrogin-1/MAFbx mRNA depends on Foxo4 expression but not AKT-Foxo1/3 signaling.
Moylan JS; Smith JD; Chambers MA; McLoughlin TJ; Reid MB
Am J Physiol Cell Physiol; 2008 Oct; 295(4):C986-93. PubMed ID: 18701653
[TBL] [Abstract][Full Text] [Related]
16. C2C12 myoblasts are more sensitive to the toxic effects of simvastatin than myotubes and show impaired proliferation and myotube formation.
Sanvee GM; Bouitbir J; Krähenbühl S
Biochem Pharmacol; 2021 Aug; 190():114649. PubMed ID: 34111424
[TBL] [Abstract][Full Text] [Related]
17. Flavones Inhibit LPS-Induced Atrogin-1/MAFbx Expression in Mouse C2C12 Skeletal Myotubes.
Shiota C; Abe T; Kawai N; Ohno A; Teshima-Kondo S; Mori H; Terao J; Tanaka E; Nikawa T
J Nutr Sci Vitaminol (Tokyo); 2015; 61(2):188-94. PubMed ID: 26052151
[TBL] [Abstract][Full Text] [Related]
18. IGF-I does not prevent myotube atrophy caused by proinflammatory cytokines despite activation of Akt/Foxo and GSK-3beta pathways and inhibition of atrogin-1 mRNA.
Dehoux M; Gobier C; Lause P; Bertrand L; Ketelslegers JM; Thissen JP
Am J Physiol Endocrinol Metab; 2007 Jan; 292(1):E145-50. PubMed ID: 16926385
[TBL] [Abstract][Full Text] [Related]
19. Furazolidone induces apoptosis through activating reactive oxygen species-dependent mitochondrial signaling pathway and suppressing PI3K/Akt signaling pathway in HepG2 cells.
Deng S; Tang S; Zhang S; Zhang C; Wang C; Zhou Y; Dai C; Xiao X
Food Chem Toxicol; 2015 Jan; 75():173-86. PubMed ID: 25434308
[TBL] [Abstract][Full Text] [Related]
20. Mechanisms involved in 3',5'-cyclic adenosine monophosphate-mediated inhibition of the ubiquitin-proteasome system in skeletal muscle.
Gonçalves DA; Lira EC; Baviera AM; Cao P; Zanon NM; Arany Z; Bedard N; Tanksale P; Wing SS; Lecker SH; Kettelhut IC; Navegantes LC
Endocrinology; 2009 Dec; 150(12):5395-404. PubMed ID: 19837877
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
