127 related articles for article (PubMed ID: 21840216)
1. Activation and inhibition of CTP synthase from Trypanosoma brucei, the causative agent of African sleeping sickness.
Steeves CH; Bearne SL
Bioorg Med Chem Lett; 2011 Sep; 21(18):5188-90. PubMed ID: 21840216
[TBL] [Abstract][Full Text] [Related]
2. Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness.
Hofer A; Steverding D; Chabes A; Brun R; Thelander L
Proc Natl Acad Sci U S A; 2001 May; 98(11):6412-6. PubMed ID: 11353848
[TBL] [Abstract][Full Text] [Related]
3. Inhibition of CTP synthase from Escherichia coli by xanthines and uric acids.
Roy AC; Lunn FA; Bearne SL
Bioorg Med Chem Lett; 2010 Jan; 20(1):141-4. PubMed ID: 20004571
[TBL] [Abstract][Full Text] [Related]
4. Identification of Trypanosoma brucei leucyl-tRNA synthetase inhibitors by pharmacophore- and docking-based virtual screening and synthesis.
Zhao Y; Wang Q; Meng Q; Ding D; Yang H; Gao G; Li D; Zhu W; Zhou H
Bioorg Med Chem; 2012 Feb; 20(3):1240-50. PubMed ID: 22249121
[TBL] [Abstract][Full Text] [Related]
5. GMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway.
Li Q; Leija C; Rijo-Ferreira F; Chen J; Cestari I; Stuart K; Tu BP; Phillips MA
Mol Microbiol; 2015 Sep; 97(5):1006-20. PubMed ID: 26043892
[TBL] [Abstract][Full Text] [Related]
6. Expression, purification, characterization, and in vivo targeting of trypanosome CTP synthetase for treatment of African sleeping sickness.
Fijolek A; Hofer A; Thelander L
J Biol Chem; 2007 Apr; 282(16):11858-65. PubMed ID: 17331943
[TBL] [Abstract][Full Text] [Related]
7. Competition between ammonia derived from internal glutamine hydrolysis and hydroxylamine present in the solution for incorporation into UTP as catalysed by Lactococcus lactis CTP synthase.
Willemoës M
Arch Biochem Biophys; 2004 Apr; 424(1):105-11. PubMed ID: 15019842
[TBL] [Abstract][Full Text] [Related]
8. Inhibition of E. coli CTP synthase by the "positive" allosteric effector GTP.
MacDonnell JE; Lunn FA; Bearne SL
Biochim Biophys Acta; 2004 Jun; 1699(1-2):213-20. PubMed ID: 15158730
[TBL] [Abstract][Full Text] [Related]
9. Mutational analysis of conserved glycine residues 142, 143 and 146 reveals Gly(142) is critical for tetramerization of CTP synthase from Escherichia coli.
Lunn FA; Macleod TJ; Bearne SL
Biochem J; 2008 May; 412(1):113-21. PubMed ID: 18260824
[TBL] [Abstract][Full Text] [Related]
10. Structural requirements for the activation of Escherichia coli CTP synthase by the allosteric effector GTP are stringent, but requirements for inhibition are lax.
Lunn FA; MacDonnell JE; Bearne SL
J Biol Chem; 2008 Jan; 283(4):2010-20. PubMed ID: 18003612
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and biological evaluation of CTP synthetase inhibitors as potential agents for the treatment of African trypanosomiasis.
Tamborini L; Pinto A; Smith TK; Major LL; Iannuzzi MC; Cosconati S; Marinelli L; Novellino E; Lo Presti L; Wong PE; Barrett MP; De Micheli C; Conti P
ChemMedChem; 2012 Sep; 7(9):1623-34. PubMed ID: 22865834
[TBL] [Abstract][Full Text] [Related]
12. Anti-trypanosomal activities of DNA topoisomerase inhibitors.
Deterding A; Dungey FA; Thompson KA; Steverding D
Acta Trop; 2005 Mar; 93(3):311-6. PubMed ID: 15715983
[TBL] [Abstract][Full Text] [Related]
13. Aspartate-107 and leucine-109 facilitate efficient coupling of glutamine hydrolysis to CTP synthesis by Escherichia coli CTP synthase.
Iyengar A; Bearne SL
Biochem J; 2003 Feb; 369(Pt 3):497-507. PubMed ID: 12383057
[TBL] [Abstract][Full Text] [Related]
14. Limited proteolysis of Escherichia coli cytidine 5'-triphosphate synthase. Identification of residues required for CTP formation and GTP-dependent activation of glutamine hydrolysis.
Simard D; Hewitt KA; Lunn F; Iyengar A; Bearne SL
Eur J Biochem; 2003 May; 270(10):2195-206. PubMed ID: 12752439
[TBL] [Abstract][Full Text] [Related]
15. Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness.
Abdeen S; Salim N; Mammadova N; Summers CM; Goldsmith-Pestana K; McMahon-Pratt D; Schultz PG; Horwich AL; Chapman E; Johnson SM
Bioorg Med Chem Lett; 2016 Nov; 26(21):5247-5253. PubMed ID: 27720295
[TBL] [Abstract][Full Text] [Related]
16. Lid L11 of the glutamine amidotransferase domain of CTP synthase mediates allosteric GTP activation of glutaminase activity.
Willemoës M; Mølgaard A; Johansson E; Martinussen J
FEBS J; 2005 Feb; 272(3):856-64. PubMed ID: 15670165
[TBL] [Abstract][Full Text] [Related]
17. Promising lead compounds for novel antiprotozoals.
Otoguro K; Iwatsuki M; Ishiyama A; Namatame M; Nishihara-Tukashima A; Shibahara S; Kondo S; Yamada H; Omura S
J Antibiot (Tokyo); 2010 Jul; 63(7):381-4. PubMed ID: 20661239
[No Abstract] [Full Text] [Related]
18. Trypanosome alternative oxidase, a potential therapeutic target for sleeping sickness, is conserved among Trypanosoma brucei subspecies.
Nakamura K; Fujioka S; Fukumoto S; Inoue N; Sakamoto K; Hirata H; Kido Y; Yabu Y; Suzuki T; Watanabe Y; Saimoto H; Akiyama H; Kita K
Parasitol Int; 2010 Dec; 59(4):560-4. PubMed ID: 20688188
[TBL] [Abstract][Full Text] [Related]
19. Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488.
Smith VC; Cleghorn LA; Woodland A; Spinks D; Hallyburton I; Collie IT; Mok NY; Norval S; Brenk R; Fairlamb AH; Frearson JA; Read KD; Gilbert IH; Wyatt PG
ChemMedChem; 2011 Oct; 6(10):1832-40. PubMed ID: 21834094
[TBL] [Abstract][Full Text] [Related]
20. Designing sleeping sickness control.
Kinoshita T
ACS Chem Biol; 2008 Oct; 3(10):601-3. PubMed ID: 18928247
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
