BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

254 related articles for article (PubMed ID: 21846118)

  • 1. Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity.
    Stefani C; Punnia-Moorthy G; Lovejoy DB; Jansson PJ; Kalinowski DS; Sharpe PC; Bernhardt PV; Richardson DR
    J Med Chem; 2011 Oct; 54(19):6936-48. PubMed ID: 21846118
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Alkyl substituted 2'-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation.
    Stefani C; Jansson PJ; Gutierrez E; Bernhardt PV; Richardson DR; Kalinowski DS
    J Med Chem; 2013 Jan; 56(1):357-70. PubMed ID: 23276209
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.
    Kalinowski DS; Yu Y; Sharpe PC; Islam M; Liao YT; Lovejoy DB; Kumar N; Bernhardt PV; Richardson DR
    J Med Chem; 2007 Jul; 50(15):3716-29. PubMed ID: 17602603
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity.
    Richardson DR; Kalinowski DS; Richardson V; Sharpe PC; Lovejoy DB; Islam M; Bernhardt PV
    J Med Chem; 2009 Mar; 52(5):1459-70. PubMed ID: 19216562
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Novel thiosemicarbazones of the ApT and DpT series and their copper complexes: identification of pronounced redox activity and characterization of their antitumor activity.
    Jansson PJ; Sharpe PC; Bernhardt PV; Richardson DR
    J Med Chem; 2010 Aug; 53(15):5759-69. PubMed ID: 20597487
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-activity studies of 4-phenyl-substituted 2'-benzoylpyridine thiosemicarbazones with potent and selective anti-tumour activity.
    Lukmantara AY; Kalinowski DS; Kumar N; Richardson DR
    Org Biomol Chem; 2013 Oct; 11(37):6414-25. PubMed ID: 23963445
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.
    Lovejoy DB; Sharp DM; Seebacher N; Obeidy P; Prichard T; Stefani C; Basha MT; Sharpe PC; Jansson PJ; Kalinowski DS; Bernhardt PV; Richardson DR
    J Med Chem; 2012 Aug; 55(16):7230-44. PubMed ID: 22861499
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and biological evaluation of 2-benzoylpyridine thiosemicarbazones in a dimeric system: structure-activity relationship studies on their anti-proliferative and iron chelation efficacy.
    Lukmantara AY; Kalinowski DS; Kumar N; Richardson DR
    J Inorg Biochem; 2014 Dec; 141():43-54. PubMed ID: 25217717
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Dipyridyl thiosemicarbazone chelators with potent and selective antitumor activity form iron complexes with redox activity.
    Richardson DR; Sharpe PC; Lovejoy DB; Senaratne D; Kalinowski DS; Islam M; Bernhardt PV
    J Med Chem; 2006 Nov; 49(22):6510-21. PubMed ID: 17064069
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and biological evaluation of substituted 2-benzoylpyridine thiosemicarbazones: novel structure-activity relationships underpinning their anti-proliferative and chelation efficacy.
    Lukmantara AY; Kalinowski DS; Kumar N; Richardson DR
    Bioorg Med Chem Lett; 2013 Feb; 23(4):967-74. PubMed ID: 23312948
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Impact of metal coordination on cytotoxicity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine) and novel insights into terminal dimethylation.
    Kowol CR; Trondl R; Heffeter P; Arion VB; Jakupec MA; Roller A; Galanski MS; Berger W; Keppler BK
    J Med Chem; 2009 Aug; 52(16):5032-43. PubMed ID: 19637923
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: structure-activity relationships of novel thiohydrazone analogues.
    Kalinowski DS; Sharpe PC; Bernhardt PV; Richardson DR
    J Med Chem; 2007 Nov; 50(24):6212-25. PubMed ID: 17963372
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis, Characterization, and in Vitro Anticancer Activity of Copper and Zinc Bis(Thiosemicarbazone) Complexes.
    Anjum R; Palanimuthu D; Kalinowski DS; Lewis W; Park KC; Kovacevic Z; Khan IU; Richardson DR
    Inorg Chem; 2019 Oct; 58(20):13709-13723. PubMed ID: 31339305
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Identification and characterization of thiosemicarbazones with antifungal and antitumor effects: cellular iron chelation mediating cytotoxic activity.
    Opletalová V; Kalinowski DS; Vejsová M; Kunes J; Pour M; Jampílek J; Buchta V; Richardson DR
    Chem Res Toxicol; 2008 Sep; 21(9):1878-89. PubMed ID: 18698850
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Novel "hybrid" iron chelators derived from aroylhydrazones and thiosemicarbazones demonstrate selective antiproliferative activity against tumor cells.
    Lovejoy DB; Richardson DR
    Blood; 2002 Jul; 100(2):666-76. PubMed ID: 12091363
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy.
    Serda M; Kalinowski DS; Mrozek-Wilczkiewicz A; Musiol R; Szurko A; Ratuszna A; Pantarat N; Kovacevic Z; Merlot AM; Richardson DR; Polanski J
    Bioorg Med Chem Lett; 2012 Sep; 22(17):5527-31. PubMed ID: 22858101
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Metal complexes of 3-(4-bromophenyl)-1-pyridin-2-ylprop-2-en-1-one thiosemicarbazone: cytotoxic activity and investigation on the mode of action of the gold(III) complex.
    Sâmia LB; Parrilha GL; Da Silva JG; Ramos JP; Souza-Fagundes EM; Castelli S; Vutey V; Desideri A; Beraldo H
    Biometals; 2016 Jun; 29(3):515-26. PubMed ID: 27091443
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis, crystal structure and antiproliferative mechanisms of 2-acetylpyridine-thiosemicarbazones Ga(III) with a greater selectivity against tumor cells.
    Qi J; Zheng Y; Qian K; Tian L; Zhang GX; Cheng Z; Wang Y
    J Inorg Biochem; 2017 Dec; 177():110-117. PubMed ID: 28946027
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure-activity relationships of novel iron chelators for the treatment of iron overload disease: the methyl pyrazinylketone isonicotinoyl hydrazone series.
    Kalinowski DS; Sharpe PC; Bernhardt PV; Richardson DR
    J Med Chem; 2008 Jan; 51(2):331-44. PubMed ID: 18159922
    [TBL] [Abstract][Full Text] [Related]  

  • 20. In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites.
    Potůčková E; Roh J; Macháček M; Sahni S; Stariat J; Šesták V; Jansová H; Hašková P; Jirkovská A; Vávrová K; Kovaříková P; Kalinowski DS; Richardson DR; Šimůnek T
    PLoS One; 2015; 10(10):e0139929. PubMed ID: 26460540
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.