BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

121 related articles for article (PubMed ID: 21856740)

  • 1. Strong activation of ether-à-go-go-related gene 1 K+ channel isoforms by NS1643 in human embryonic kidney 293 and Chinese hamster ovary cells.
    Schuster AM; Glassmeier G; Bauer CK
    Mol Pharmacol; 2011 Nov; 80(5):930-42. PubMed ID: 21856740
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mechanism of action of a novel human ether-a-go-go-related gene channel activator.
    Casis O; Olesen SP; Sanguinetti MC
    Mol Pharmacol; 2006 Feb; 69(2):658-65. PubMed ID: 16284303
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).
    Hansen RS; Diness TG; Christ T; Demnitz J; Ravens U; Olesen SP; Grunnet M
    Mol Pharmacol; 2006 Jan; 69(1):266-77. PubMed ID: 16219910
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Effects of the small molecule HERG activator NS1643 on Kv11.3 channels.
    Bilet A; Bauer CK
    PLoS One; 2012; 7(11):e50886. PubMed ID: 23226420
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The human ether-a-go-go-related gene activator NS1643 enhances epilepsy-associated KCNQ channels.
    Li P; Chen X; Zhang Q; Zheng Y; Jiang H; Yang H; Gao Z
    J Pharmacol Exp Ther; 2014 Dec; 351(3):596-604. PubMed ID: 25232191
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Activation of ERG2 potassium channels by the diphenylurea NS1643.
    Elmedyb P; Olesen SP; Grunnet M
    Neuropharmacology; 2007 Aug; 53(2):283-94. PubMed ID: 17610913
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels.
    Larsen AP; Bentzen BH; Grunnet M
    Br J Pharmacol; 2010 Oct; 161(3):614-28. PubMed ID: 20880400
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Potent activation of large-conductance Ca2+-activated K+ channels by the diphenylurea 1,3-bis-[2-hydroxy-5-(trifluoromethyl)phenyl]urea (NS1643) in pituitary tumor (GH3) cells.
    Wu SN; Peng H; Chen BS; Wang YJ; Wu PY; Lin MW
    Mol Pharmacol; 2008 Dec; 74(6):1696-704. PubMed ID: 18809671
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-guided topographic mapping and mutagenesis to elucidate binding sites for the human ether-a-go-go-related gene 1 potassium channel (KCNH2) activator NS1643.
    Durdagi S; Guo J; Lees-Miller JP; Noskov SY; Duff HJ
    J Pharmacol Exp Ther; 2012 Aug; 342(2):441-52. PubMed ID: 22573844
    [TBL] [Abstract][Full Text] [Related]  

  • 10. NS1643 enhances ionic currents in a G604S-WT hERG co-expression system associated with long QT syndrome 2.
    Huo J; Guo X; Lu Q; Qiang H; Liu P; Bai L; Huang CL; Zhang Y; Ma A
    Clin Exp Pharmacol Physiol; 2017 Nov; 44(11):1125-1133. PubMed ID: 28741726
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Effects of TRH on heteromeric rat erg1a/1b K+ channels are dominated by the rerg1b subunit.
    Kirchberger NM; Wulfsen I; Schwarz JR; Bauer CK
    J Physiol; 2006 Feb; 571(Pt 1):27-42. PubMed ID: 16339175
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Molecular determinants of human ether-à-go-go-related gene 1 (hERG1) K+ channel activation by NS1643.
    Grunnet M; Abbruzzese J; Sachse FB; Sanguinetti MC
    Mol Pharmacol; 2011 Jan; 79(1):1-9. PubMed ID: 20876384
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243).
    Xu X; Recanatini M; Roberti M; Tseng GN
    Mol Pharmacol; 2008 Jun; 73(6):1709-21. PubMed ID: 18372399
    [TBL] [Abstract][Full Text] [Related]  

  • 14. NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.
    Guo J; Cheng YM; Lees-Miller JP; Perissinotti LL; Claydon TW; Hull CM; Thouta S; Roach DE; Durdagi S; Noskov SY; Duff HJ
    Biophys J; 2015 Mar; 108(6):1400-1413. PubMed ID: 25809253
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds.
    Hull CM; Genge CE; Hobbs Y; Rayani K; Lin E; Gunawan M; Shafaattalab S; Tibbits GF; Claydon TW
    Am J Physiol Regul Integr Comp Physiol; 2019 Dec; 317(6):R921-R931. PubMed ID: 31664867
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Erg K+ channels modulate contractile activity in the bovine epididymal duct.
    Mewe M; Wulfsen I; Schuster AM; Middendorff R; Glassmeier G; Schwarz JR; Bauer CK
    Am J Physiol Regul Integr Comp Physiol; 2008 Mar; 294(3):R895-904. PubMed ID: 18184764
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Differential expression of hERG1 channel isoforms reproduces properties of native I(Kr) and modulates cardiac action potential characteristics.
    Larsen AP; Olesen SP
    PLoS One; 2010 Feb; 5(2):e9021. PubMed ID: 20126398
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Computational analysis of the effects of the hERG channel opener NS1643 in a human ventricular cell model.
    Peitersen T; Grunnet M; Benson AP; Holden AV; Holstein-Rathlou NH; Olesen SP
    Heart Rhythm; 2008 May; 5(5):734-41. PubMed ID: 18452879
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel.
    Perissinotti LL; Guo J; De Biase PM; Clancy CE; Duff HJ; Noskov SY
    Biophys J; 2015 Mar; 108(6):1414-1424. PubMed ID: 25809254
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD-307243) causes instantaneous current through human ether-a-go-go-related gene potassium channels.
    Gordon E; Lozinskaya IM; Lin Z; Semus SF; Blaney FE; Willette RN; Xu X
    Mol Pharmacol; 2008 Mar; 73(3):639-51. PubMed ID: 18042732
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.