362 related articles for article (PubMed ID: 21858031)
1. LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding.
Taymans JM; Vancraenenbroeck R; Ollikainen P; Beilina A; Lobbestael E; De Maeyer M; Baekelandt V; Cookson MR
PLoS One; 2011; 6(8):e23207. PubMed ID: 21858031
[TBL] [Abstract][Full Text] [Related]
2. The R1441C mutation of LRRK2 disrupts GTP hydrolysis.
Lewis PA; Greggio E; Beilina A; Jain S; Baker A; Cookson MR
Biochem Biophys Res Commun; 2007 Jun; 357(3):668-71. PubMed ID: 17442267
[TBL] [Abstract][Full Text] [Related]
3. GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2.
Biosa A; Trancikova A; Civiero L; Glauser L; Bubacco L; Greggio E; Moore DJ
Hum Mol Genet; 2013 Mar; 22(6):1140-56. PubMed ID: 23241358
[TBL] [Abstract][Full Text] [Related]
4. GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease.
Ito G; Okai T; Fujino G; Takeda K; Ichijo H; Katada T; Iwatsubo T
Biochemistry; 2007 Feb; 46(5):1380-8. PubMed ID: 17260967
[TBL] [Abstract][Full Text] [Related]
5. The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity.
Guo L; Gandhi PN; Wang W; Petersen RB; Wilson-Delfosse AL; Chen SG
Exp Cell Res; 2007 Oct; 313(16):3658-70. PubMed ID: 17706965
[TBL] [Abstract][Full Text] [Related]
6. The Roc-COR tandem domain of leucine-rich repeat kinase 2 forms dimers and exhibits conventional Ras-like GTPase properties.
Mills RD; Liang LY; Lio DS; Mok YF; Mulhern TD; Cao G; Griffin M; Kenche VB; Culvenor JG; Cheng HC
J Neurochem; 2018 Nov; 147(3):409-428. PubMed ID: 30091236
[TBL] [Abstract][Full Text] [Related]
7. The dual enzyme LRRK2 hydrolyzes GTP in both its GTPase and kinase domains in vitro.
Liu Z; West AB
Biochim Biophys Acta Proteins Proteom; 2017 Mar; 1865(3):274-280. PubMed ID: 27939437
[TBL] [Abstract][Full Text] [Related]
8. Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities.
Webber PJ; Smith AD; Sen S; Renfrow MB; Mobley JA; West AB
J Mol Biol; 2011 Sep; 412(1):94-110. PubMed ID: 21806997
[TBL] [Abstract][Full Text] [Related]
9. Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants.
Li X; Tan YC; Poulose S; Olanow CW; Huang XY; Yue Z
J Neurochem; 2007 Oct; 103(1):238-47. PubMed ID: 17623048
[TBL] [Abstract][Full Text] [Related]
10. LRRK2 autophosphorylation enhances its GTPase activity.
Liu Z; Mobley JA; DeLucas LJ; Kahn RA; West AB
FASEB J; 2016 Jan; 30(1):336-47. PubMed ID: 26396237
[TBL] [Abstract][Full Text] [Related]
11. The R1441C mutation alters the folding properties of the ROC domain of LRRK2.
Li Y; Dunn L; Greggio E; Krumm B; Jackson GS; Cookson MR; Lewis PA; Deng J
Biochim Biophys Acta; 2009 Dec; 1792(12):1194-7. PubMed ID: 19781641
[TBL] [Abstract][Full Text] [Related]
12. The GTPase function of LRRK2.
Taymans JM
Biochem Soc Trans; 2012 Oct; 40(5):1063-9. PubMed ID: 22988866
[TBL] [Abstract][Full Text] [Related]
13. Revisiting the Roco G-protein cycle.
Terheyden S; Ho FY; Gilsbach BK; Wittinghofer A; Kortholt A
Biochem J; 2015 Jan; 465(1):139-47. PubMed ID: 25317655
[TBL] [Abstract][Full Text] [Related]
14. Kinetic mechanistic studies of wild-type leucine-rich repeat kinase 2: characterization of the kinase and GTPase activities.
Liu M; Dobson B; Glicksman MA; Yue Z; Stein RL
Biochemistry; 2010 Mar; 49(9):2008-17. PubMed ID: 20146535
[TBL] [Abstract][Full Text] [Related]
15. The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites.
Greggio E; Taymans JM; Zhen EY; Ryder J; Vancraenenbroeck R; Beilina A; Sun P; Deng J; Jaffe H; Baekelandt V; Merchant K; Cookson MR
Biochem Biophys Res Commun; 2009 Nov; 389(3):449-54. PubMed ID: 19733152
[TBL] [Abstract][Full Text] [Related]
16. The unconventional G-protein cycle of LRRK2 and Roco proteins.
Terheyden S; Nederveen-Schippers LM; Kortholt A
Biochem Soc Trans; 2016 Dec; 44(6):1611-1616. PubMed ID: 27913669
[TBL] [Abstract][Full Text] [Related]
17. ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2.
Haebig K; Gloeckner CJ; Miralles MG; Gillardon F; Schulte C; Riess O; Ueffing M; Biskup S; Bonin M
PLoS One; 2010 Oct; 5(10):e13762. PubMed ID: 21048939
[TBL] [Abstract][Full Text] [Related]
18. Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant.
Daniƫls V; Vancraenenbroeck R; Law BM; Greggio E; Lobbestael E; Gao F; De Maeyer M; Cookson MR; Harvey K; Baekelandt V; Taymans JM
J Neurochem; 2011 Jan; 116(2):304-15. PubMed ID: 21073465
[TBL] [Abstract][Full Text] [Related]
19. Mechanism of the guanine nucleotide exchange reaction of Ras GTPase--evidence for a GTP/GDP displacement model.
Zhang B; Zhang Y; Shacter E; Zheng Y
Biochemistry; 2005 Feb; 44(7):2566-76. PubMed ID: 15709769
[TBL] [Abstract][Full Text] [Related]
20. Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3.
Muda K; Bertinetti D; Gesellchen F; Hermann JS; von Zweydorf F; Geerlof A; Jacob A; Ueffing M; Gloeckner CJ; Herberg FW
Proc Natl Acad Sci U S A; 2014 Jan; 111(1):E34-43. PubMed ID: 24351927
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]